The relationship of fibroblast growth factors 21 and 23 and α-Klotho with platelet activity measured by platelet volume indices

Abstract

Background: Subjects with high fibroblast growth factor 21(FGF21) and 23 (FGF23), endocrine hormones that regulate insulin sensitivity and phosphate metabolism, respectively, are reported to have a higher risk for adverse cardiovascular outcome. Therefore, the relationship of FGF21, FGF23, and α-Klotho (co-receptor for FGF23 signaling) with mean platelet volume (MPV) and platelet distribution width (PDW), two platelet volume indices that reflect platelet activity, was investigated. Methods: Data from 156 patients admitted to the cardiology department were analyzed. MPV and PDW were measured by an automatic blood counter, and serum FGF21, FGF23, and α-Klotho concentrations were measured by an enzyme-linked immunoassay. Results: Log(FGF21) was significantly correlated with serum triglycerides but did not differ according to the use of non-use of antidiabetic or lipid-lowering drugs. MPV and PDW were significantly correlated (R = 0.475, p < 0.001). MPV was significantly correlated with log(FGF21) (R = -0.167, p < 0.05) and log(FGF23) (R = 0.351, p < 0.001) but not with log(α-Klotho). Linear regression analysis showed a negative and positive association of log(FGF21) and log(FGF23), respectively, with MPV that was independent of possible confounders including sex, age, renal function, and antithrombotic drug use. In addition, log(FGF23)

New endocrine biomarkers and cardiovascular disease: is it time for routinely screening?

“…In conclusion, the results by Fujita et al [8] on the association between platelet activity and these two biomarkers seem to add knowledge in this field. The novel diagnostic approaches may include the FGF21 and FGF23 as targets for treatment of patients with high cardiovascular risk, such as CKD subjects, but this need to be confirmed in large prospective randomized trials.…”

“…In the present issue of the journal, Fujita et al [8] investigate the association between FGF21, FGF23, and α-klotho levels and mean platelet volume (MPV) and platelet distribution width (PDW) in 156 patients affected by cardiovascular disease. Interestingly, MPV was significantly associated negatively with log(FGF21) and positively with log(FGF23), even when antithrombotic drug use was consider in the multivariate analysis.…”