The Relationship of Fatigue and Depression with Trace Element Levels in Epileptic Patients

Gündoğdu, Ayşe; Bolattürk, Ömer Faruk; Aygül, Recep; Akyürek, Fıkret

doi:10.1007/s12011-022-03258-8

Cited by 4 publications

(5 citation statements)

References 38 publications

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“…Interestingly, according to a recent meta-analysis, a majority of human studies have found Se concentration in epileptic patients to be lower than in healthy controls (40). However, a recent study found that serum Se concentration was significantly higher in epileptic patients compared to controls (41), which is consistent with our results. We have also recently shown that dogs with IE have significantly higher Se concentration in the hair, even if they are not receiving ASD treatment (manuscript in revision).…”

Section: Discussionsupporting

confidence: 94%

Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study

et al. 2023

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BackgroundIdiopathic epilepsy (IE) is the most common neurological disease in dogs. Multiple genes and environmental factors interact to cause clinical signs, although the pathogenesis remains poorly understood. Extensive evidence from recent decades shows that trace elements play a role in epilepsy in humans, and recently it was shown for the first time that also dogs with IE have altered trace element status. On the other hand, toxic metals may cause seizures but research on their role in canine IE is lacking. Therefore, we aimed to investigate trace element and toxic metal concentrations in whole blood from dogs that had been diagnosed with IE and compare them to those of healthy dogs.Materials and methodsWhole blood concentrations of trace elements (selenium, zinc, copper, manganese, iron, and chromium) and toxic metals (arsenic, cadmium, mercury, and lead) were analyzed from 19 dogs that had been diagnosed with IE by board-certified neurologists and 19 healthy control dogs using inductively coupled plasma mass spectrometry. The concentrations in study and control group were compared using the Mann-Whitney U test.ResultsDogs diagnosed with IE had significantly higher blood copper concentration (P = 0.007), higher copper/zinc ratio (P = 0.04), and higher selenium concentration (P < 0.001), as well as lower chromium concentration (P = 0.01) when compared to healthy dogs. Treatment of IE with potassium bromide was associated with a significant elevation in blood arsenic concentration (P = 0.01).ConclusionIn conclusion, the present results support the role of altered trace element status in dogs diagnosed with IE and suggest that copper, selenium, and chromium may be involved in the pathogenesis of canine epilepsy or seizures. The results also suggest that potassium bromide may alter arsenic metabolism in dogs.

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Section: Discussionsupporting

confidence: 94%

Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study

et al. 2023

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“…The study by Saad et al (2014) demonstrated that the average serum selenium level of patients with epilepsy is significantly lower than that in the control group (4.2 ± 1.3 μg/dl vs. 8.3 ± 2.3 μg/dl; p < 0.001), which is consistent with the findings of Chakrabarty et al (2022) (89.7 ± 13.6 μg/dl vs. 95.79 ± 12.66 μg/dl; p = 0.008). In contrast, Gündoğdu et al (2023) reported that the average level of selenium was significantly higher in the epilepsy group than in the control group (71.95 ± 21.19 μg/l vs. 36.84 ± 9.08 μg/l; p < 0.001). Moreover, another study demonstrated that the serum selenium concentration did differ significantly between untreated patients with epilepsy and individuals in the control group ( Das et al, 2019 ).…”

Section: Changes In Trace Element Levels In Patients With Epilepsymentioning

confidence: 81%

“…Patients with epilepsy having serum zinc levels of <70 μg/dl exhibit a 3.56 times greater risk of epilepsy than do those having serum zinc levels of 70–120 μg/dl ( Das et al, 2019 ). However, another study reported that the serum zinc concentration of untreated patients with epilepsy is significantly higher than that of controls ( Saghazadeh et al, 2015 ), and there is no significant difference in zinc levels between the epilepsy and control group ( Gündoğdu et al, 2023 ). In addition, a study on the treatment of refractory epilepsy in children using oral zinc supplementation showed that 31% of children in the intervention group exhibited improvement, while only 4.5% of children in the placebo group did, with a significantly lower frequency of seizures in the intervention group compared to the placebo group ( p = 0.02) ( Saad et al, 2015 ).…”

Section: Changes In Trace Element Levels In Patients With Epilepsymentioning

confidence: 95%

“…Copper alone inhibits magnesium and sodium-potassium ATPases, leading to changes in sodium and potassium levels, which in turn increases susceptibility to seizures ( Donaldson et al, 1971 ; Garg et al, 2021 ; Nemati et al, 2021 ; Sharma et al, 2021 ). Some studies have shown an increase in serum copper levels in the epilepsy group compared to those of the control group ( Wojciak et al, 2013 ; Gündoğdu et al, 2023 ), while others have reported no significant difference between the two groups ( Sözüer et al, 1995 ; Chwiej et al, 2008 ). Another study found that the average copper level is significantly higher in the epilepsy group than in the control group (180.1 ± 32.4 μg/dl vs. 114.5 ± 18.5 μg/dl; p < 0.001) ( Talat et al, 2015 ).…”

Section: Changes In Trace Element Levels In Patients With Epilepsymentioning

confidence: 97%

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Research progress on correlations between trace element levels and epilepsy

Liu

Zhang

et al. 2023

Front. Cell Dev. Biol.

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Research investigating the correlation between human trace element levels and disease alterations is growing. Epilepsy, a common nervous system disease, has also been found to be closely related to abnormal levels of trace elements. Studies continue to explore mechanisms of various trace elements involved in epileptic seizures through experimental animal models of epilepsy. Thus, we reviewed the research progress on the correlation between trace element levels and epilepsy in recent years and found that the trace elements most closely related to epilepsy are mainly metal ions such as selenium, iron, copper, zinc, and manganese. These results indicate that the changes in some trace elements are closely related to the increase in epilepsy susceptibility. In addition, after treatment with drugs and a ketogenic diet, the concentration of trace elements in the serum of patients with epilepsy changes. In other words, the abnormality of trace element concentrations is of great significance in the occurrence and development of epilepsy. This article is a literature update on the potential role of trace element imbalance in the development of epilepsy, providing new references for the subsequent prevention and treatment of epilepsy.

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“…31 (58) who proved that education and support intervention are significantly effective in improving the self-efficacy, self-esteem, which positively reflected on QOL of patient with epilepsy. With the extension of H3: considering patients' energy/fatigue, the study conducted by Gündoğdu et al, (2023); (59) Seid and Mebrahtu (2022) (60) reported that, patients with epilepsy frequently experience feeling of tiredness and fatigue. Furthermore, the majority of participants report that fatigue is a further complication of their condition that is linked to depression and is thought to be a factor that can trigger seizures.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Designed Educational Protocol on Quality of Life among Patients with Epilepsy

Mohamed,

Abd-Elghany,

Shady

et al. 2023

Tanta Scientific Nursing Journal

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Background: Epilepsy is a disabling neurological disorder worldwide, affecting quality of life, which imposes a great burden on patients and their caregivers. Improving the quality of life is precisely one of the main objectives of therapeutic education, which are considered the gold standard in the delivery of health care. Aim: To evaluate the effect of a designed educational protocol on quality of life among patients with epilepsy. Design: A quasi-experimental research design using a one-group (pre-posttest) approach was used. Setting: The study was conducted at inpatient neurological department and outpatient clinics affiliated to Mansoura Main University Hospital. Subjects: A purposive sample of 100 patients diagnosed with epilepsy were selected. Tools: Four tools were used for data collection: Tool I: Structured interview questionnaire, Tool II: Knowledge assessment questionnaire, Tool III: Epilepsy self-management scale, and Tool IV: Quality of life in epilepsy inventory-31(QOLIE-31) scale. Results: There was a high statistically significance difference in the total mean score of knowledge, self-management practices, and quality of life pre and post implementing the designed educational protocol among the studied patients (p<.001). There was a significant positive correlation between the total score of knowledge, self-management practices among the studied patients and their quality of life at 3 and 6 months post implementing the designed educational protocol (p<.001& p=.006; p=0.022&p =0.041) respectively. Conclusion: The designed educational protocol proved that, there was an improvement in the knowledge and self-management practices total scores of the studied patients, which consequently had a positive effect on their quality of life. Recommendation: The designed educational protocol should be planned in a continuous manner and applied on regular basis to patients with epilepsy.

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The Relationship of Fatigue and Depression with Trace Element Levels in Epileptic Patients

Cited by 4 publications

References 38 publications

Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study

Whole blood trace element and toxic metal concentration in dogs with idiopathic epilepsy and healthy dogs: A case-control study

Research progress on correlations between trace element levels and epilepsy

Effect of a Designed Educational Protocol on Quality of Life among Patients with Epilepsy

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