The Relationship of CRP/Albumin ratio level and prognosis in pregnant COVID-19 patients

YILMAZ, Nezir; Tosun, Fadime; Cömert, Ercan; Duran, Mustafa; Tuna, Verda

doi:10.4103/njcp.njcp_244_22

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Thus, the index [Urea] × [MDA]/(BChEb × [ALB]) can claim to take a place among the most promising indices proposed to date, among which there is none that includes the activity of BChE and at the same time demonstrates such striking differences at the stage of admission to the clinic between survivors and those who died during treatment from COVID-19. At the same time, it should be mentioned that most of the proposed indices include albumin in the denominator: LDH/[ALB], [Lact]/[ALB], [Fibr]/[ALB], [Urea]/[ALB], and [CRP]/[ALB] [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Importantly, correlation analysis independent of age and concomitant pathology showed that the ratio of [CRP]/[ALB] negatively correlates with oxygen saturation (SO 2 ), spirometric indices (FEV1, forced expiratory volume in the first second, and FVC, forced volume capacity) and lung diffusion values (DLCO, carbon monoxide diffusion capacity) [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Belinskaia

Voronina

Попова

et al. 2023

IJMS

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The esterase status of blood plasma can claim to be one of the universal markers of various diseases; therefore, it deserves attention when searching for markers of the severity of COVID-19 and other infectious and non-infectious pathologies. When analyzing the esterase status of blood plasma, the esterase activity of serum albumin, which is the major protein in the blood of mammals, should not be ignored. The purpose of this study is to expand understanding of the esterase status of blood plasma and to evaluate the relationship of the esterase status, which includes information on the amount and enzymatic activity of human serum albumin (HSA), with other biochemical parameters of human blood, using the example of surviving and deceased patients with confirmed COVID-19. In experiments in vitro and in silico, the activity of human plasma and pure HSA towards various substrates was studied, and the effect of various inhibitors on this activity was tested. Then, a comparative analysis of the esterase status and a number of basic biochemical parameters of the blood plasma of healthy subjects and patients with confirmed COVID-19 was performed. Statistically significant differences have been found in esterase status and biochemical indices (including albumin levels) between healthy subjects and patients with COVID-19, as well as between surviving and deceased patients. Additional evidence has been obtained for the importance of albumin as a diagnostic marker. Of particular interest is a new index, [Urea] × [MDA] × 1000/(BChEb × [ALB]), which in the group of deceased patients was 10 times higher than in the group of survivors and 26 times higher than the value in the group of apparently healthy elderly subjects.

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Section: Resultsmentioning

confidence: 99%

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Belinskaia

Voronina

Попова

et al. 2023

IJMS

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“…[ 51 ] Notably, some studies have explored the potential link between cytokines and COVID-19, including the relevance of CRP levels to the prognosis of pregnant individuals with COVID-19. [ 52 , 53 ] The bibliometric analysis counts the most influential authors, journals, countries/regions, and institutions and shows some of their characteristics. During the early days of the COVID-19 outbreak, pregnant women with the virus experienced several pregnancy complications, such as fetal distress, premature rupture of membranes, preterm delivery, and stillbirth.…”

Section: Discussionmentioning

confidence: 99%

Global research on emerging trends of obstetrics during the COVID-19 pandemic: A bibliometric analysis

Cai,

Pan,

Deng

et al. 2024

Medicine

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Coronavirus disease-2019 (COVID-19) has caused continuous effects on the global public, especially for susceptible and vulnerable populations like pregnant women. COVID-19-related studies and publications have shown blowout development, making it challenging to identify development trends and hot areas by using traditional review methods for such massive data. Aimed to perform a bibliometric analysis to explore the status and hotspots of COVID-19 in obstetrics. An online search was conducted in the Web of Science Core Collection (WOSCC) database from January 01, 2020 to November 31, 2022, using the following search expression: (((TS= (“COVID 19” OR “coronavirus 2019” OR “coronavirus disease 2019” OR “SARS-CoV-2” OR “2019-nCoV” OR “2019 novel coronavirus” OR “SARS coronavirus 2” OR “Severe Acute Respiratory Syndrome Coronavirus-2” OR “SARS-COV2”)) AND TS= (“obstetric*” OR “pregnancy*” OR “pregnant” OR “parturition*” OR “puerperium”))). VOSviewer version 1.6.18, CiteSpace version 6.1.R6, R version 4.2.0, and Rstudio were used for the bibliometric and visualization analyses. 4144 articles were included in further analysis, including authors, titles, number of citations, countries, and author affiliations. The United States has contributed the most significant publications with the leading position. “Sahin, Dilek” has the largest output, and “Khalil, Asma” was the most influential author with the highest citations. Keywords of “Cov,” “Experience,” and “Neonate” with the highest frequency, and “Systematic Review” might be the new research hotspots and frontiers. The top 3 concerned genes included ACE2, CRP, and IL6. The new research hotspot is gradually shifting from the COVID-19 mechanism and its related clinical research to reviewing treatment options for pregnant women. This research uniquely delves into specific genes related to COVID-19’s effects on obstetrics, a focus that has not been previously explored in other reviews. Our research enables clinicians and researchers to summarize the overall point of view of the existing literature and obtain more accurate conclusions.

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“…CAR is a ratio that is able to show both the inflammatory response and the nutritional status at the same time. Recent studies have also identified CAR as a prognostic biomarker for the inflammatory process [23][24][25]. However, it has not been investigated in cases of threatened preterm birth.…”

Section: Cut-offmentioning

confidence: 99%

The Efficacy of C‐Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor

Seyhanli,

Bayraktar,

Cakir

et al. 2024

American J Rep Immunol

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ObjectiveTo investigate the role of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), c‐reactive protein (CRP) to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and fibrinogen to CRP ratio (FCR) in predicting the latency period (≤72 vs. >72 hours) before preterm birth.Materials and MethodsIn a retrospective study, we assessed 135 patients meeting the specified criteria with signs of preterm labor (<34 weeks). The patients were categorized into two groups: 71 patients giving birth within 72 h (latency ≤ 72 h) and 64 patients giving birth after 72 h (latency > 72 h). We examined the demographic and medical characteristics and perinatal outcomes of all participants. Categorical variables between groups were compared using the Chi‐square test. The Student's t‐test was utilized for normally distributed continuous variables, and the Mann–Whitney U test was applied for non‐normally distributed data. Receiver operating characteristic (ROC) curve analysis was conducted to identify the optimal cut‐off levels for inflammatory markers in predicting the latency period before birth.ResultsAmong the parameters examined, significant differences were observed between the groups only in terms of CAR and FCR. While CAR showed a significantly higher value in the group with latency period ≤72 h (0.537 ± 1.239 vs. 0.247 ± 0.325, p = 0.022), FCR showed a significantly lower value in the group with latency period ≤72 h (63.58 (2.99–1165) vs. 88.93 (9.35–1165), p = 0.013). The identified cut‐off value for CAR was 0.190, providing a sensitivity of 57.7% and a specificity of 56.3% (p = 0.022). The cut‐off value for FCR was 71.67, with a sensitivity of 42.3% and a specificity of 42.2% (p = 0.013).ConclusionsThe CAR and the FCR, serving as predictive markers for preterm labor, may offer a simple, cost‐effective, and easily accessible approach, particularly in resource‐limited settings.

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The Relationship of CRP/Albumin ratio level and prognosis in pregnant COVID-19 patients

Cited by 6 publications

References 29 publications

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Albumin Is a Component of the Esterase Status of Human Blood Plasma

Global research on emerging trends of obstetrics during the COVID-19 pandemic: A bibliometric analysis

The Efficacy of C‐Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor

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