The Relationship of Carotid Arterial Stiffness and Left Ventricular Concentric Hypertrophy in Hypertension

Abstract

al and functional arterial changes contribute to the pathophysiology of LVH. One concept is that arterial remodeling might parallel left ventricular (LV) remodeling due to pressure overload and additional non-hemodynamic factors in hypertension [2]. This phenomenon might have an impact on the inAssessment of both left ventricular hypertrophy (LVH) and abnormal structure and function of the conduit arteries as features of the target organ damage (TOD) is crucial in the risk stratification and management of patients with arterial hypertension Objectives. The aim of the study was to test the hypothesis that carotid artery stiffness, as a marker of vascular damage, is associated with CH, independently of other potential determinants such as demographic factors (age, sex, BMI), clinical parameters (smoking, diabetes, creatinine level) and hemodynamic variables (blood pressure, pulse pressure [PP]). Material and Methods. The study involved 262 subjects (89 men): 202 patients with hypertension (153 untreated, 49 on medication), aged 55.7 ± 10 years, and 60 age-matched normal controls. The subjects were examined by echocardiography and carotid ultrasound with a high-resolution echo-tracking system. Based on the left ventricular mass index (LVMI) and relative wall thickness (RWT), the patients with hypertension were divided into four patterns of LVH and geometry: normal geometry (N, n = 57), concentric remodeling (CR, n = 48), concentric hypertrophy CH (n = 62) and eccentric hypertrophy (EH, n = 35). Intima-media thickness (IMT) and the parameters of arterial stiffness were also assessed using the β stiffness index (β), Young elastic modulus (Ep), arterial compliance (AC), one-point pulse wave velocity (PWVβ) and the wave reflection augmentation index (AI).

Uterine Fibroids and the Risk of Cardiovascular Disease in the Coronary Artery Risk Development in Young Adult Women's Study

“…[2][3][4]9 Hypertension is multifactorial, but has been related to vascular wall thickness and stiffness, and leads to atherosclerosis. 10 However, in most of these studies, hypertension was more strongly related to fibroid cases that led to hysterectomy rather than fibroid cases detected before needing surgical intervention. 4,8,9 We aimed to study the association between fibroids and CVD using markers of subclinical disease to further elucidate possible common pathways: (1) wall thickness and vascular stiffness using markers of carotid intima media thickness (CIMT) and left ventricular (LV) mass and (2) plaque formation using coronary artery calcification (CAC).…”

Blood pressure limits affecting carotid artery injury: a cross sectional study

“…Carotid elasticity and distensibility are two important parameters that can be easily evaluated by ultrasonography and show subclinical atherosclerosis. The role of both elasticity and distensibility in predicting cardiovascular adverse events has been demonstrated in previous studies [5][6][7] .…”

Is carotid stiffness a possible surrogate for stroke in long-term survivors of childhood cancer after neck radiotherapy?

“…18 Brouwer et al in LTSCC even found a negative association between carotid IMT and treatment with anthracyclines, both as categorical variables [yes/no] and per 100mg/m2 cumulative dose. 22 Further, Bowers et al observed no association between ChT and the risk of stroke in patients treated for HD in childhood. 5 To our knowledge, only one study dealing with LTSCC suggested that anthracyclines causes impaired endothelial function, which is early event in atherogenesis.…”

“…PWV, the one-point pulse wave velocity (m/s), is calculated from the time delay between two adjacent distension waveforms from water hammer equation with the use of the β stiffness parameter 22 :…”