THE RELATIONSHIP OF CARDIOPULMONARY FITNESS TO PLASMA FIBRINOGEN, PLASMINOGEN ACTIVATOR INHIBITOR-1, AND LIPOPROPTEIN[a] IN HEALTHY POSTMENOPAUSAL WOMEN 11

Jae, Sae Young; Hong, Kyung Pyo; Kang, Jay Y.; Sy, Oh; Choo, Jin A; Ann, Eue Soo; Park, Won H.

doi:10.1097/00008483-199809000-00027

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“…Blood fibrinogen level can be elevated by stress, lack of exercise, and an increased in blood cholesterols or triglycerides as a result of increased fat intake [24]. Once blood fibrinogens promote to thrombosis, the thrombi flow in the blood and block capillaries, and then results in the various arterial occlusive diseases, including myocardial infarction and ischemia [20].…”

Section: Fibrinolytic Activitymentioning

confidence: 99%

The Effects of Aerobic Exercise Training on Blood Lipid Profiles, Fibrinolytic Activities, and Nitric Oxide Levels in High-fat-diet induced Rats

Son¹,

Kim²,

Sung³

et al. 2015

Journal of Life Science

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Although exercise training has been utilized to improve vascular function in animals and humans, the impact of moderate intensity exercise training on fibrinolytic activities and nitric oxide (NO) bioavailability has not been well documented. Therefore, the purpose of the current study was to examine the impact of moderate intensity aerobic exercise training on fat mass, blood lipid profiles, fibrinolytic activity, and NO levels in high-fat-diet induced rats. The body weight, fat mass, blood lipid profiles, fibrinolytic activity, and nitrite/nitrate were measured pre-and postexercise (10 weeks) training. The body weight and fat mass reduced significantly in the exercise (EX) group compared to the control (CON) group. Blood lipid profiles and low-density lipoprotein were unchanged in the EX group compared to the CON group. However, triglyceride and free fatty acid were significantly lower in the EX group compared to the CON group, and high-density lipoprotein was significantly greater in the EX group compared to the CON group. In addition, fibrinolytic activity and nitrite/nitrate were significantly greater in the EX compared to the CON group. These results suggest that 10 weeks of the moderated intensity aerobic exercise training improves blood lipid profiles, fibrinolytic activity, and the nitrite/nitrate ratio, which may improve vascular health and reduce obesity-related cardiovascular disease risks in high-fat-diet induced rats.

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Section: Fibrinolytic Activitymentioning

confidence: 99%