The Relationship of Ca and P Nutrition during Adult Life and Osteoporosis in Aged Mice

Shah, B. G.; Krishnarao, G. V. G.; Draper, H. H.

doi:10.1093/jn/92.1.30

Cited by 81 publications

(12 citation statements)

References 19 publications

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“…Ten-month-old female C57BL/6 mice that had been fed a diet of 1.2% calcium and 0.6% Pi (Ca:P = 2:1) showed the best ash content, cortical thickness and breaking load, respectively. By contrast, mice fed a diet of 1.2% calcium and 1.2% Pi (Ca:P = 1:1) showed the lowest values for parameters related to the mineral content of bones (Shah et al, 1967).…”

Section: Influence Of Pi On Bone Resorption In Animalsmentioning

confidence: 82%

Biological effects of inorganic phosphate: potential signal of toxicity

et al. 2015

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-Inorganic phosphate (Pi) plays crucial roles in several biological processes and signaling pathways. Pi uptake is regulated by sodium-dependent phosphate (Na/Pi) transporters (NPTs). Moreover, Pi is used as a food additive in food items such as sausages, crackers, dairy products, and beverages. However, the high serum concentration of phosphate (> 5.5 mg/dL) can cause adverse renal effects, cardiovascular effects including vascular or valvular calcification, and stimulate bone resorption. In addition, Pi can also alter vital cellular signaling, related to cell growth and cap-dependent protein translation. Moreover, intake of dietary Pi, whether high (1.0%) or low (0.1%), affects organs in developing mice, and is related to tumorigenesis in mice. The recommended dietary allowance (RDA) of Pi is the daily dietary intake required to maintain levels above the lower limit of the range of normal serum Pi concentration (2.7 mg/dL) for most individuals (97-98%). Thus, adequate intake of Pi (RDA; 700 mg/day) and maintenance of normal Pi concentration (2.7-4.5 mg/dL) are important for health and prevention of diseases caused by inadequate Pi intake.

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Section: Influence Of Pi On Bone Resorption In Animalsmentioning

confidence: 82%

Biological effects of inorganic phosphate: potential signal of toxicity

et al. 2015

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“…Early studies in animals show that high dietary phosphorus, particularly with low dietary calcium, reduces bone mass, and that this is mediated by secondary hyperparathyroidism (28–31). Draper et al (30) demonstrated that parathyroidectomy prevented increased bone resorption in response to a high phosphorus diet in adult rats.…”

Section: High Dietary Phosphorus Intake Effects On Bone Healthmentioning

confidence: 99%

Effects of Excessive Dietary Phosphorus Intake on Bone Health

Vorland

Stremke

Moorthi

et al. 2017

Curr Osteoporos Rep

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Purpose of Review The purpose of this review is to provide an overview of dietary phosphorus, its sources, recommended intakes, and its absorption and metabolism in health and in chronic kidney disease, and to discuss recent findings in this area with a focus on the effects of inorganic phosphate additives in bone health. Recent Findings Recent findings show that increasing dietary phosphorus through inorganic phosphate additives has detrimental effects on bone and mineral metabolism in humans and animals. There is new data supporting an educational intervention to limit phosphate additives in patients with chronic kidney disease to control serum phosphate. Summary The average intake of phosphorus in the US well-above the recommended dietary allowance. Inorganic phosphate additives, which are absorbed at a high rate, account for a substantial and likely underestimated portion of this excessive intake. These additives have negative effects on bone metabolism, and present a prime opportunity to lower total phosphorus intake in the U.S. Further evidence is needed to confirm whether lowering dietary phosphorus intake would have beneficial effects to improve fracture risk.

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“…In many animal models, chronic low calcium intake produces osteopenia [37][38][39][40][41][42]. The osteopenia affects cancellous bone more than cortical bone and may not be completely reversible with calcium supplementation [42].…”

Section: Skeletal Pathophysiologymentioning

confidence: 99%

Effects of Calcium and Vitamin D Insufficiency on the Skeleton

Peacock

1998

Osteoporos Int

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The Relationship of Ca and P Nutrition during Adult Life and Osteoporosis in Aged Mice

Cited by 81 publications

References 19 publications

Biological effects of inorganic phosphate: potential signal of toxicity

Biological effects of inorganic phosphate: potential signal of toxicity

Effects of Excessive Dietary Phosphorus Intake on Bone Health

Effects of Calcium and Vitamin D Insufficiency on the Skeleton

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