The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study

Linneberg, Allan; Petersen, Janne; Nielsen, Niels; Madsen, Flemming; Frølund, L.; Dirksen, Asger; Jørgensen, Torben

doi:10.1046/j.1365-2222.2003.01515.x

Cited by 63 publications

(103 citation statements)

References 30 publications

(49 reference statements)

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“…smoking and alcohol a pattern that was also similar to the pattern reported elsewhere: allergen-specific IgE levels were increasing with alcohol consumption 24 and were decreased among smokers. 25 A major strength of our study, in addition to the large numbers of cases and controls, is the careful assessment of atopy by specific IgE measurement.…”

Section: Discussionsupporting

confidence: 87%

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Wang

Rothenbacher

Löw

et al. 2006

Intl Journal of Cancer

136

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There is increasing epidemiological evidence for a role of allergic/ atopic disorders in cancer development. However, findings have been inconsistent, which may be partly due to differences in defining allergy and the associated atopic disorders. The use of a biological marker for atopy may enhance the exploration of the association with cancer risks. To examine the association of atopy with common malignancies, we compared the prevalence of atopy in 318 patients with prostate cancer, 381 patients with breast cancer, 196 patients with lung cancer, 477 patients with colorectal cancer and 4,271 controls in a case-control analysis of participants of 2 prospective studies conducted in Saarland, Germany. Data on physician-diagnosed atopy-related diseases (asthma, hay fever and atopic dermatitis) were obtained by self-administered questionnaire. Allergen-specific immunoglobulin E (IgE) was assessed among cases and controls to define atopy. We observed a significantly increased risk of prostate cancer (odds ratio (OR) 1.35, 95% confidence interval (CI) 1.00-1.83) and a tentatively, statistically not significant increased risk of breast cancer (OR 1.20, 95% CI 0.87-1.66) and lung cancer (OR 1.29, 95% CI 0.87-1.92) with specific IgE positivity. No consistent associations were found with atopyrelated diseases. Our findings are consistent with other epidemiological evidence suggesting an increased risk of prostate cancer with atopy and indicate a complex association between atopy/atopyrelated diseases and cancer risk that varies by type of atopy-related disorders and the particular type of cancer under consideration. The effect on cancer risk by atopy, defined by IgE reactivity, may differ from the effect by atopy-related clinically defined diseases such as asthma, hay fever and atopic dermatitis. ' 2006 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 87%

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Wang

Rothenbacher

Löw

et al. 2006

Intl Journal of Cancer

136

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“…Similar to our findings, few other studies have found a relation between alcohol abuse and raised total IgE [10,[20][21][22]. A recent Korean study showed an increased prevalence of allergic sensitization to house dust mite in alcoholics [20].…”

Section: Resultssupporting

confidence: 92%

“…A recent Korean study showed an increased prevalence of allergic sensitization to house dust mite in alcoholics [20]. There are few other studies also suggesting an association between increased IgE and allergic sensitization in alcoholics [22][23][24]. In control subjects who showed high total IgE levels (>500 IU/ml), specific IgE levels were measured against common allergens (house dust, tree, and food allergens) to detect an allergic component.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Kumar¹

2015

Immunochem Immunopathol

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Long-term intake of alcohol affects virtually every organ in the body including the immune system. The relation between alcohol abuse and immunoglobulin production has not been studied in Indian population. Serum levels of immunoglobulins (total IgE, IgG, IgM, and IgA) therefore, were analyzed in adult chronic alcoholics and were correlated with different epidemiological and alcohol-related parameters. The results showed that 98% of alcoholics had abnormal immunoglobulin levels and 92% showed high or very high total serum IgE levels compared to 24% of the control group. Long term and moderate consumption of alcohol were also associated with frequent infections. Serum immunoglobulin assay including total IgE may be helpful in screening and assessment of chronicity of alcohol abuse.

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“…In other studies, alcohol beverages consumption has been associated with increased risk for asthma and hay fever symptoms, allergic sensitization and serum IgE (45)(46)(47). The aMED score, used in the present study, considers total ethanol intake, irrespective of the different alcoholic beverages.…”

Section: Discussionmentioning

confidence: 98%

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Barros

Moreira

Fonseca

et al. 2008

Allergy

121

104

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Background: The traditional Mediterranean diet is claimed to possess antioxidant and immune‐regulatory properties in several chronic diseases. Typical Mediterranean foods have recently been associated with improvement of symptoms of asthma and rhinitis in children. However the effect of adherence to Mediterranean diet on adult asthma outcomes is unknown. We aimed to investigate the association between adherence to Mediterranean diet and asthma control.Methods: Cross sectional study of 174 asthmatics, mean (SD) age of 40 (15) years. The patients were defined as controlled, in contrast to noncontrolled, if they showed FEV1 ≥ 80% of predicted, exhaled nitric oxide (NO) ≤35 ppb, and Asthma Control Questionnaire score <1. Dietary intake was obtained by a food frequency questionnaire, and Mediterranean diet was assessed by alternate Mediterranean Diet (aMED) Score. Logistic regression models adjusting for confounders were performed to estimate the association between Mediterranean diet and asthma control.Results: Controlled asthmatics (23%) had significantly higher aMED Score, intake of fresh fruit, and lower intake of ethanol compared to noncontrolled (77%). High adherence to Mediterranean diet reduced 78% the risk of noncontrolled asthma after adjusting for gender, age, education, inhaled corticosteroids and energy intake (OR = 0.22; 95% CI = 0.05–0.85; P‐trend = 0.028). The higher intake of fresh fruit decreased the probability of having noncontrolled asthma (OR = 0.29; 95% CI = 0.10–0.83; P‐trend = 0.015), while the higher intake of ethanol had the opposite effect (OR = 3.16; 95% CI = 1.10–9.11; P‐trend = 0.035).Conclusion: High adherence to traditional Mediterranean diet increased the likelihood of asthma to be under control in adults. The study introduces a novel link between diet and asthma control, as measured by symptoms, lung function and exhaled NO.

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The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study

Cited by 63 publications

References 30 publications

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum

Evaluation of Serum Immunoglobulins IgG, IgA, IgM and Total IgE in Chronic Alcoholics: A Community-based Study

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

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