The Relationship of ABO Blood Group, Age, Gender, Smoking, and Helicobacter pylori Infection

Abstract

It is well known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. This study sought to determine the relationship between H. pylori and ABO/Rhesus blood groups, age, gender, and smoking. Patients (335 women and 205 men; mean age, 51.68 +/- 15.0 years; range, 18-85 years) who attended our outpatient clinic were enrolled in the study. All patients were randomly selected in each age group. Demographic data recorded for each patient included age, gender, and tobacco use. Blood samples were tested for H. pylori antibodies, and ABO/Rhesus blood group antigen typing was performed. Serum antibodies were tested against H. pylori infection. Prevalences of all blood groups were O (29.2%), A (38.2%), B (17.8%), and AB (14.8%). As expected from previous studies, we found that seropositivity for H. pylori increased with age. H. pylori Ig G antibody positivity was detected in 185 of 335 women (60.6%), compared with 88 of 205 men (42.9%), a statistically significant difference (P < 0.05). H. pylori Ig G antibody positivity was detected in 206 of 379 nonsmokers (54.3%) compared with 67 of 161 smokers (41.6%), a statistically significant difference (P < 0.05). Patients in blood groups A and O were more prone to H. pylori infection than were patients in other blood groups (P < 0.05), and patients in the AB blood group were less prone to H. pylori infection compared with patients in other blood groups (P < 0.05). The results of this study demonstrate that H. pylori infection can be related to ABO blood group, age, gender, and smoking.

Factors Associated with Helicobacter Pylori Infection, Results from a Developing Country-Pakistan

“…Helicobacter pylori infection is the most common chronic bacterial infection around the world (Kanbay et al, 2005). It has been shown that 50% adult in developed countries and 90% adults in developing countries were positive of serum antibodies against H. pylori (Wu et al, 2003).…”

“…Studies have discovered a blood group antigen binding adhesin (BabA), which help the organism to adhere to the epithelial cells (Martins et al, 2006). Boren et al demonstrated that, the H and Leb antigens of the ABH and Lewis (Le) blood group systems are the receptors on gastric epithelial cells for H pylori (Kanbay et al, 2005). It has been shown that gastric mucosa of blood group O are more prone for the attachment of H pylori, because they had more receptors, and Lewisb antigens mediated the attachment of H. pylori to the mucosa (Kanbay et al, 2005).…”

“…Boren et al demonstrated that, the H and Leb antigens of the ABH and Lewis (Le) blood group systems are the receptors on gastric epithelial cells for H pylori (Kanbay et al, 2005). It has been shown that gastric mucosa of blood group O are more prone for the attachment of H pylori, because they had more receptors, and Lewisb antigens mediated the attachment of H. pylori to the mucosa (Kanbay et al, 2005). Furthermore, these individuals are at high risk of developing gastric and duodenal ulcers because higher density of colonization of the pathogen was reported with the people having blood group O (Kanbay et al, 2005).…”

“…It has been shown that gastric mucosa of blood group O are more prone for the attachment of H pylori, because they had more receptors, and Lewisb antigens mediated the attachment of H. pylori to the mucosa (Kanbay et al, 2005). Furthermore, these individuals are at high risk of developing gastric and duodenal ulcers because higher density of colonization of the pathogen was reported with the people having blood group O (Kanbay et al, 2005). It has also been shown for many years, that blood group A had been associated with gastric carcinoma, while duodenal ulcer was associated with group O; however no explanation for this association was received (Kanbay et al, 2005).…”

“…Furthermore, these individuals are at high risk of developing gastric and duodenal ulcers because higher density of colonization of the pathogen was reported with the people having blood group O (Kanbay et al, 2005). It has also been shown for many years, that blood group A had been associated with gastric carcinoma, while duodenal ulcer was associated with group O; however no explanation for this association was received (Kanbay et al, 2005).…”