The relationship between white matter microstructure and self-perceived cognitive decline

Archer, Derek B.; Moore, Elizabeth E.; Pamidimukkala, Ujwala; Shashikumar, Niranjana; Pechman, Kimberly R.; Blennow, Kaj; Zetterberg, Henrik; Landman, Bennett A.; Hohman, Timothy J.; Jefferson, Angela L.; Gifford, Katherine A.

doi:10.1016/j.nicl.2021.102794

Cited by 12 publications

(13 citation statements)

References 70 publications

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“…Although the relationship between baseline hippocampal volume and fornix FA with long-term memory change were in the expected direction, baseline hippocampal free-water was the only metric that reached significance in MA+ ASD. Our findings agree with our previous work and others who have shown free-water is more sensitive for detecting neurodegeneration in mild cognitive impairment, Alzheimer's, and Parkinson's disease than traditional MRI metrics, such as hippocampal volume and FA (Ofori et al, 2015a(Ofori et al, , 2017(Ofori et al, , 2019Guttuso et al, 2018;Reas et al, 2018;Archer et al, 2021;Dzieciol et al, 2021;Shahid et al, 2022;Zhou et al, 2022). We have previously shown baseline free-water in the substantia nigra predicts cognitive decline associated with Parkinson's disease (Ofori et al, 2015b), and others have demonstrated that baseline hippocampal free-water was a stronger predictor of follow-up cognitive status in Parkinson's disease than hippocampal volume or conventional DTI metrics (Guttuso et al, 2021).…”

Section: Baseline Hippocampal System Correlates Of Memory Declinesupporting

confidence: 93%

“…We were the first to establish that this novel, advanced DTI measure which is more sensitive for detecting neurodegeneration in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease than conventional MRI metrics (Ofori et al, 2015a(Ofori et al, , 2017(Ofori et al, , 2019. These findings have since been replicated by other laboratories (Guttuso et al, 2018;Reas et al, 2018;Archer et al, 2021;Dzieciol et al, 2021;Shahid et al, 2022;Zhou et al, 2022). Most recently, Guttuso et al (2021) demonstrated that baseline hippocampal free-water was a stronger predictor of follow-up cognitive status in Parkinson's disease than hippocampal volume or conventional DTI metrics.…”

Section: Introductionmentioning

confidence: 78%

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Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water

Walsh

Ofori

Pagni

et al. 2022

Front. Aging Neurosci.

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Research aimed at understanding cognitive and brain aging in adults with autism spectrum disorder (ASD) is growing, but critical longitudinal work is scant. Adults with ASD struggle with tasks involving visual memory compared with neurotypical adults (NT). This may be related to differences in size or integrity of the hippocampus and its’ primary structural connectivity pathway, the fornix. The aim of this study was to describe preliminary findings of longitudinal aging trajectories in short- and long-term visual memory abilities in middle-age and older adults with ASD, compared with matched NT adults. We then evaluated baseline multi-modal imaging metrics of the hippocampal system, including the relatively novel metric of free-water, as potential correlates of longitudinal memory change in the ASD group. Middle-age and older adults with ASD (n = 25) and matched NT adults (n = 25) between the ages of 40 and 70 years were followed longitudinally at ~2-year intervals (range 2–5 years). Participants completed the Wechsler Memory Scale III Visual Reproduction task. Longitudinal mixed models were utilized to detect group differences in memory change with baseline age and sex as covariates. Hippocampal volume was measured via T1-weighted MRI images with FreeSurfer. Fornix fractional anisotropy and hippocampal and fornix free-water were measured from diffusion tensor imaging scans. Exploratory correlations were run between individual hippocampal system metrics and longitudinal slopes of visual memory change. There was a significant group by time interaction for long-term visual memory, such that middle-age and older adults with ASD declined faster than matched NT adults. There was no group by time interaction for short-term visual memory. Baseline hippocampal free-water was the only hippocampal system metric that correlated with long-term visual memory change in the ASD group. As one of the first longitudinal cognitive and brain aging studies in middle-age and older adults with ASD, our findings suggest vulnerabilities for accelerated long-term visual memory decline, compared to matched NT adults. Further, baseline hippocampal free-water may be a predictor of visual memory change in middle-age and older adults with ASD. These preliminary findings lay the groundwork for future prognostic applications of MRI for cognitive aging in middle-age and older adults with ASD.

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Section: Baseline Hippocampal System Correlates Of Memory Declinesupporting

confidence: 93%

Section: Introductionmentioning

confidence: 78%

Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water

Walsh

Ofori

Pagni

et al. 2022

Front. Aging Neurosci.

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“…30 In this study, WM changes associated with normal brain aging were observed in older healthy adults relative to younger healthy adults, especially in the CG, IFOF, ILF, and UF which have previously been shown to be linked to higher-order cognitive functions. 31,32 These findings show that aging can affect WM microstructural integrity and is, therefore, an important consideration when assessing structural integrity of cerebral WM pathways in the brains of IHD patients undergoing both aging and vascular-related changes.…”

Section: Discussionmentioning

confidence: 81%

Probing Evidence of Cerebral White Matter Microstructural Disruptions in Ischemic Heart Disease Before and Following Cardiac Rehabilitation: A Diffusion Tensor MR Imaging Study

Poirier,

Suskin,

Khaw

et al. 2023

Magnetic Resonance Imaging

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BackgroundIschemic heart disease (IHD) is linked to brain white matter (WM) breakdown but how age or disease effects WM integrity, and whether it is reversible using cardiac rehabilitation (CR), remains unclear.PurposeTo assess the effects of brain aging, cardiovascular disease, and CR on WM microstructure in brains of IHD patients following a cardiac event.Study TypeRetrospective.PopulationThirty‐five IHD patients (9 females; mean age = 59 ± 8 years), 21 age‐matched healthy controls (10 females; mean age = 59 ± 8 years), and 25 younger controls (14 females; mean age = 26 ± 4 years).Field Strength/Sequence3 T diffusion‐weighted imaging with single‐shot echo planar imaging acquired at 3 months and 9 months post‐cardiac event.AssessmentTract‐based spatial statistics (TBSS) and tractometry were used to compare fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) in cerebral WM between: 1) older and younger controls to distinguish age‐related from disease‐related WM changes; 2) IHD patients at baseline (pre‐CR) and age‐matched controls to investigate if cardiovascular disease exacerbates age‐related WM changes; and 3) IHD patients pre‐CR and post‐CR to investigate the neuroplastic effect of CR on WM microstructure.Statistical TestsTwo‐sample unpaired t‐test (age: older vs. younger controls; IHD: IHD pre‐CR vs. age‐matched controls). One‐sample paired t‐test (CR: IHD pre‐ vs. post‐CR). Statistical threshold: P < 0.05 (FWE‐corrected).ResultsTBSS and tractometry revealed widespread WM changes in older controls compared to younger controls while WM clusters of decreased FA in the fornix and increased MD in body of corpus callosum were observed in IHD patients pre‐CR compared to age‐matched controls. Robust WM improvements (increased FA, increased AD) were observed in IHD patients post‐CR.Data ConclusionIn IHD, both brain aging and cardiovascular disease may contribute to WM disruptions. IHD‐related WM disruptions may be favorably modified by CR.Level of Evidence3Technical EfficacyStage 2

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“…In conclusion, as no preliminary studies have been performed regarding the associations between cognitive performance and these SNPs in FTD, these results highlight the value of incorporating multiple biomarkers to help disentangle the mechanistic heterogeneity of cognitive decline ( 46 ). Our results may constitute a starting point for future studies involving these SNPs and their relationship with cognitive performance in patients with a probable diagnosis of FTD.…”

Section: Discussionmentioning

confidence: 97%

Association between risk polymorphisms for neurodegenerative diseases and cognition in colombian patients with frontotemporal dementia

et al. 2022

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Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disease of presenile onset. A better characterization of neurodegenerative disorders has been sought by using tools such as genome-wide association studies (GWAS), where associations between single nucleotide polymorphisms (SNPs) and cognitive profiles could constitute predictive biomarkers for these diseases. However, in FTD, associations between genotypes and cognitive phenotypes are yet to be explored. Here, we evaluate a possible relationship between genetic variants and some cognitive functions in an FTD population.MethodologyA total of 47 SNPs in genes associated with neurodegenerative diseases were evaluated using the Sequenom MassARRAY platform along with their possible relationship with performance in neuropsychological tests in 105 Colombian patients diagnosed with FTD.Results and discussionThe SNPs rs429358 (APOE), rs1768208 (MOBP), and rs1411478 (STX6), were identified as risk factors for having a low cognitive performance in inhibitory control and phonological verbal fluency. Although the significance level was not enough to reach the corrected alpha for multiple comparison correction, our exploratory data may constitute a starting point for future studies of these SNPs and their relationship with cognitive performance in patients with a probable diagnosis of FTD. Further studies with an expansion of the sample size and a long-term design could help to explore the predictive nature of the potential associations we identified.

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The relationship between white matter microstructure and self-perceived cognitive decline

Abstract: Highlights RD T within several white matter tracts is associated with SCD. RD T contributes unique variance to SCD beyond that of CSF Aβ 42 . Our findings suggest that RD T is a sensitive marker of SCD.

Cited by 12 publications

References 70 publications

Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water

Preliminary findings of accelerated visual memory decline and baseline brain correlates in middle-age and older adults with autism: The case for hippocampal free-water

Probing Evidence of Cerebral White Matter Microstructural Disruptions in Ischemic Heart Disease Before and Following Cardiac Rehabilitation: A Diffusion Tensor MR Imaging Study

Association between risk polymorphisms for neurodegenerative diseases and cognition in colombian patients with frontotemporal dementia

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