The Relationship between Vitamin D Levels and Iron Deficiency and Anemia in Adults Applied for Periodic Medical Examination

Nur-Eke, Remziye; Ozen, Mehmet

doi:10.7754/clin.lab.2019.190918

Cited by 6 publications

(6 citation statements)

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“…Some cross-sectional studies documented that vitamin D has a role in erythropoiesis, and that VDD is accompanied by an increased risk of anemia (Sim et al, 2010; Thomas et al, 2015). This finding was further supported by other observational studies (De la Cruz-Góngora, Salinas-Rodríguez, Flores-Aldana, and Villalpando, 2021; Nur-Eke and Özen, 2020; Ellen M. Smith and Tangpricha, 2015). Along the same line, a study in Iranian children also reported an association of VDD with iron deficiency and resulting anemia (Bahareh Nikooyeh and Neyestani, 2018).…”

Section: Introductionsupporting

confidence: 87%

Improvement of vitamin D status through consumption of either fortified food products or supplement pills increased hemoglobin concentration in adult subjects: Analysis of pooled data from two randomized clinical trials

et al. 2022

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Background: It is documented that vitamin D may have a role in erythropoiesis as its deficiency is accompanied by an increased risk of anemia. Aim: This study aimed to examine whether improvement of vitamin D status through daily consumption of either fortified foods or supplements could impinge on certain hematologic parameters in adults. Methods: We pooled data from our two separate clinical trials and made five experimental groups. As part of their usual diet, one group consumed 500 mL/day of yogurt drink fortified with 1000 IU of vitamin D (D-yogurt, n = 27) whereas one group consumed 500 mL/day of the plain yogurt drink (P-yogurt, n = 27). In addition three other groups consumed either 50 g/day bread fortified with 1000 IU of vitamin D (D-bread) or supplement containing 1000 IU vitamin D (D-supplement, n = 27) or placebo (placebo, n = 27). Biochemical measurements were performed before and after the intervention. Results: In all three vitamin D-supplemented groups, serum 25(OH)D concentration increased after the intervention period, which was interestingly accompanied by a significant increment of hemoglobin (D-yogurt, p < 0.001, D-bread, p = 0.003, D-supplement, p < 0.001). Analyses indicated that among participants in vitamin D-intervention groups, being in D-yogurt group was more favourable predictor of improvement in hemoglobin concentrations compared with the placebo ( p < 0.001), D-bread ( p = 0.045) and P-yogurt ( p = 0.001). Conclusion: Improvement of vitamin D status via regular intake of either vitamin D-fortified food products or supplements can result in a significant increment of hemoglobin in adult subjects. This finding has very important clinical as well as public health implications.

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Section: Introductionsupporting

confidence: 87%

Improvement of vitamin D status through consumption of either fortified food products or supplement pills increased hemoglobin concentration in adult subjects: Analysis of pooled data from two randomized clinical trials

et al. 2022

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“…In this meta-analysis, supplementation with vitamin D had no significant effect on hemoglobin levels, whereas a positive effect on transferrin saturation and iron status was observed ( 43 ). A recent study of 9,590 adults who presented for periodic medical examination in a sunny Mediterranean city affirmed that 25(OH)D deficiency is significantly associated with iron deficiency ( 6 ). The considerable expression of the vitamin D receptor and 1-α-hydroxylase in the inflamed intestine ( 39 ) and elevated hepcidin levels in the inflammatory state leading to anemia of chronic disease ( 29 , 33 , 34 ) point toward a disease-specific mechanism by which vitamin D counteracts iron deficiency in chronic inflammatory diseases, such as IBD.…”

Section: Discussionmentioning

confidence: 99%

“…With a prevalence ranging between 16% and 95%, vitamin D deficiency seems to occur more frequently in patients with IBD than in the general population ( 3 ). There is increasing evidence that vitamin D deficiency also predisposes to anemia ( 5 , 6 ), the most common systemic complication of IBD ( 7 ). Anemia affects up to two-thirds of patients, especially at first diagnosis and in active disease ( 8 ), and considerably impairs quality of life for patients with IBD ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression

Stallhofer

Veith

Diegelmann

et al. 2022

Clinical and Translational Gastroenterology

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INTRODUCTION: Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorption. METHODS: Iron parameters and serum levels of 25-hydroxyvitamin D (25(OH)D), 1,25(OH)D, and hepcidin were measured in 104 adult patients with IBD (67 with Crohn's disease and 37 with ulcerative colitis). Genes involved in iron absorption were tested for induction by 1,25(OH)D in Caco-2 cells, which resemble the small intestinal epithelium. RESULTS: In multiple regression models controlling for age, sex, body mass index, smoking status, disease activity, and C-reactive protein levels, low 25(OH)D levels were associated with iron deficiency in patients with IBD (β [SE] = −0.064 [0.030], P = 0.029). Vitamin D sufficiency was associated with increased levels of ferritin (β [SE] = 0.25 [0.11], P = 0.024) and transferrin saturation (β [SE] = 8.41 [4.07], P = 0.044). Higher 1,25(OH)D:25(OH)D ratios were associated with lower hepcidin levels (β [SE] = −4.31 [1.67], P = 0.012). Especially in Crohn's disease, increased 1,25(OH)D correlated with higher transferrin saturation (β [SE] = 0.43 [0.18], P = 0.027). Furthermore, 1,25(OH)D strongly induced the expression of the ferroxidase ceruloplasmin in Caco-2 cells. DISCUSSION: Low vitamin D levels in IBD correlate with iron deficiency. Vitamin D may ameliorate iron deficiency, potentially by downregulating hepcidin and upregulating ceruloplasmin, enhancing intestinal iron absorption.

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“…Figure 3 showed a reduction in Iron status and Vitamin B12 in individuals suffered from VDD, which makes the possibility of having iron-deficiency anemia and megaloblastic anemia more than normal persons (Sim et al, 2010). The association between the prevalence of IDA and VDD has been recorded in previous results (Nur-Eke and Özen, 2020). The mechanism of positive relation between the depletion of vitamin D of iron status is still not well understood.…”

Section: Resultsmentioning

confidence: 70%

Vitamin D Deficiency is Associated with Anemia, Cardiovascular Risk, and Lifestyle

et al. 2021

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Traditionally, Vitamin D has been associated primarily with bone health, while further investigations revealed that a sufficient amount is important for many organ functions. Data of 314 individuals were obtained from Erbil governorate public and private hospitals from patients admitted to there for testing their level of Vitamin D and other tests according to their doctor’s prescription. The variable related to their lifestyle, metabolic syndrome, and hematology evaluations were obtained. The body mass index , number of sleeping hours, number of hours spent with electronic devices, serum lipid level anemia-related tests were measured. The results showed that serum 25(OH) Vitamin D levels in studied individuals were related to hyperlipidemia serum cholesterol measures. The level of Vitamin B12 and Iron status were lower in the Vitamin D deficiency (VDD) individuals. Mean platelet volume was higher in vitamin-deficient patients which induces the risk of cardiovascular (CV) diseases. This finding suggests the relation between VDD and metabolic syndrome, CV, and anemia-related measurement.

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The Relationship between Vitamin D Levels and Iron Deficiency and Anemia in Adults Applied for Periodic Medical Examination

Cited by 6 publications

References 0 publications

Improvement of vitamin D status through consumption of either fortified food products or supplement pills increased hemoglobin concentration in adult subjects: Analysis of pooled data from two randomized clinical trials

Improvement of vitamin D status through consumption of either fortified food products or supplement pills increased hemoglobin concentration in adult subjects: Analysis of pooled data from two randomized clinical trials

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression

Vitamin D Deficiency is Associated with Anemia, Cardiovascular Risk, and Lifestyle

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