The relationship between visual orienting and interlimb synchrony in a patient with a superior parietal infarction: A case study

Procacci, Nicole; Stanford, Terrence R.; Wittenberg, George F.

doi:10.1080/13554790802620558

Cited by 3 publications

(2 citation statements)

References 68 publications

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“…The brain putatively plans visually guided action in the PPC, as suggested by neurophysiological studies in non-human primates, in imaging studies in healthy humans, and in human patients with cerebral injuries ( 74 , 106 – 108 ). In non-human primate studies, electrophysiological results have revealed effector-specific regions in the PPC, with the parietal reach region relating to arm movements and the LIP area relating to saccadic activity.…”

Section: Sensorimotor Control: Ocular (Eye) and Manual (Hand)mentioning

confidence: 96%

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

et al. 2017

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Acute and chronic disease processes that lead to cerebral injury can often be clinically challenging diagnostically, prognostically, and therapeutically. Neurodegenerative processes are one such elusive diagnostic group, given their often diffuse and indolent nature, creating difficulties in pinpointing specific structural abnormalities that relate to functional limitations. A number of studies in recent years have focused on eye–hand coordination (EHC) in the setting of acquired brain injury (ABI), highlighting the important set of interconnected functions of the eye and hand and their relevance in neurological conditions. These experiments, which have concentrated on focal lesion-based models, have significantly improved our understanding of neurophysiology and underscored the sensitivity of biomarkers in acute and chronic neurological disease processes, especially when such biomarkers are combined synergistically. To better understand EHC and its connection with ABI, there is a need to clarify its definition and to delineate its neuroanatomical and computational underpinnings. Successful EHC relies on the complex feedback- and prediction-mediated relationship between the visual, ocular motor, and manual motor systems and takes advantage of finely orchestrated synergies between these systems in both the spatial and temporal domains. Interactions of this type are representative of functional sensorimotor control, and their disruption constitutes one of the most frequent deficits secondary to brain injury. The present review describes the visually mediated planning and control of eye movements, hand movements, and their coordination, with a particular focus on deficits that occur following neurovascular, neurotraumatic, and neurodegenerative conditions. Following this review, we also discuss potential future research directions, highlighting objective EHC as a sensitive biomarker complement within acute and chronic neurological disease processes.

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Section: Sensorimotor Control: Ocular (Eye) and Manual (Hand)mentioning

confidence: 96%

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

et al. 2017

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show abstract

“…It is widely accepted that cerebral pathology can impair ocular motor and manual motor control. This is true in indolent and chronic processes such as neurodegeneration and in acute processes such as stroke or those secondary to neurotrauma ( 1 – 5 ). More recently, it has been suggested that disruptions in these control systems are useful markers for prognostication and longitudinal monitoring ( 6 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

Eye Control Deficits Coupled to Hand Control Deficits: Eye–Hand Incoordination in Chronic Cerebral Injury

et al. 2017

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It is widely accepted that cerebral pathology can impair ocular motor and manual motor control. This is true in indolent and chronic processes, such as neurodegeneration and in acute processes such as stroke or those secondary to neurotrauma. More recently, it has been suggested that disruptions in these control systems are useful markers for prognostication and longitudinal monitoring. The utility of examining the relationship or the coupling between these systems has yet to be determined. We measured eye and hand-movement control in chronic, middle cerebral artery stroke, relative to healthy controls, in saccade-to-reach paradigms to assess eye–hand coordination. Primary saccades were initiated significantly earlier by stroke participants relative to control participants. However, despite these extremely early initial saccades to the target, reaches were nevertheless initiated at approximately the same time as those of control participants. Control participants minimized the time period between primary saccade onset and reach initiation, demonstrating temporal coupling between eye and hand. In about 90% of all trials, control participants produced no secondary, or corrective, saccades, instead maintaining fixation in the terminal position of the primary saccade until the end of the reach. In contrast, participants with stroke increased the time period between primary saccade onset and reach initiation. During this temporal decoupling, multiple saccades were produced in about 50% of the trials with stroke participants making between one and five additional saccades. Reaches made by participants with stroke were both longer in duration and less accurate. In addition to these increases in spatial reach errors, there were significant increases in saccade endpoint errors. Overall, the magnitude of the endpoint errors for reaches and saccades were correlated across participants. These findings suggest that in individuals with otherwise intact visual function, the spatial and temporal relationships between the eye and hand are disrupted poststroke, and may need to be specifically targeted during neurorehabilitation. Eye–hand coupling may be a useful biomarker in individuals with cerebral pathology in the setting of neurovascular, neurotraumatic, and neurodegenerative pathology.

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Hemispheric Asymmetries of the Premotor Cortex are Task Specific as Revealed by Disruptive TMS During Bimanual Versus Unimanual Movements

2010

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The premotor cortex (PMC) is functionally lateralized, such that the left PMC is activated for unimanual movements of either hand, whereas the right PMC is particularly active during complex bimanual movements. Here we ask the question whether the high activation of right PMC in the bimanual context reflects either hemispheric specialization or handedness. Left- and right-handed subjects performed a bimanual antiphase tapping task at different frequencies while transcranial magnetic stimulation (TMS) was used to temporarily disrupt left versus right PMC during complex bimanual movements. For both handedness groups, more disruptions were induced when TMS was applied over the motor nondominant PMC than over the motor dominant PMC or when sham-TMS was used. In a second experiment, right-handers performed complex unimanual tapping with either hand, while TMS was applied to the PMC in both hemispheres. The novel result was that the high susceptibility of the motor nondominant PMC was specific to the bimanual context, indicating that hemispheric asymmetries of the PMC depend on the bimanual versus unimanual nature of the motor task. We hypothesize that asymmetries of PMC involvement in bimanual control reflect interhemispheric interactions, whereby the motor nondominant PMC appears to prevent motor cross talk arising from the dominant hemisphere.

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The relationship between visual orienting and interlimb synchrony in a patient with a superior parietal infarction: A case study

Cited by 3 publications

References 68 publications

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

Eye Control Deficits Coupled to Hand Control Deficits: Eye–Hand Incoordination in Chronic Cerebral Injury

Hemispheric Asymmetries of the Premotor Cortex are Task Specific as Revealed by Disruptive TMS During Bimanual Versus Unimanual Movements

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