The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population

Hirata, Aya; Okamura, Tomonori; Sugiyama, Daisuke; Kuwabara, Kazuyo; Kadota, Aya; Fujiyoshi, Akira; Miura, Katsuyuki; Okuda, Nagako; Ohkubo, Takayoshi; Okayama, Akira; Ueshima, Hirotsugu

doi:10.5551/jat.33449

Cited by 49 publications

(64 citation statements)

References 38 publications

(32 reference statements)

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“…[4][5][6][7][8] However, some studies showed that high levels of HDL-C are paradoxically associated with high mortality and vascular events. [9][10][11] In clinical trials, elevating HDL-C levels by inhibition of CETP failed to decrease cardiovascular disease. [13][14][15] The first CETP inhibitor, torcetrapib, increased the risk of mortality and morbidity of cardiovascular disease rather than reducing the risk of cardiovascular events, while torcetrapib increased HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

“…31 All participants were divided into 4 groups according to the definitions used in a previous study in Japan: low HDL-C (,40 mg/dL), moderate HDL-C (40-59 mg/dL), high HDL-C (60-79 mg/dL), and extremely high HDL-C ($80 mg/dL). 9,32 The ethical committees of the participating institutions approved the study protocol. The study was executed in accordance with the Good Clinical Practice guidelines.…”

Section: Subjectsmentioning

confidence: 99%

“…[5][6][7][8] However, cohort studies have shown that an extremely high HDL-C group had high mortality and morbidity rates of cardiovascular disease and that there was a U-shaped curve between HDL-C levels and mortality and morbidity rates of cardiovascular disease. [9][10][11] In addition, recent large clinical trials have shown that an increase in HDL-C levels with pharmacologic interventions does not reduce the risk of cardiovascular events. Cholesteryl ester transfer protein (CETP) modulates the transfer of cholesteryl esters from HDL to apolipoprotein B-containing lipoproteins.…”

Section: Introductionmentioning

confidence: 99%

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Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men

Takaeko

Matsui

Kajikawa

et al. 2019

Journal of Clinical Lipidology

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BACKGROUND: It is not clear whether a high level of high-density lipoprotein cholesterol (HDL-C) is associated with lower risk of atherosclerosis. It is likely that HDL-C is a double-edged sword for atherosclerosis. OBJECTIVE: The purpose of this study was to evaluate the relationship between HDL-C levels and endothelial function in men. METHODS: This was a cross-sectional study. We evaluated flow-mediated vasodilation (FMD) and serum levels of HDL-C in 5842 men aged 18 to 92 years who were not receiving lipid-lowering therapy. All participants were divided into four groups by HDL-C level: low HDL-C (,40 mg/dL),

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men

Takaeko

Matsui

Kajikawa

et al. 2019

Journal of Clinical Lipidology

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“…Представленные данные не дают возможности определить верхний порог концентрации ХС ЛВП, выше которого происходит ухудшение результатов, хотя по данным ряда исследователей высокий уровень ХС ЛВП не только обладает превентивным действием, но, наоборот, может способствовать ухудшению состояния (>2,0 ммоль/л). Близкие результаты получены японскими авторами, которые в течение 20 лет наблюдали 7019 чел., при этом уровень ХС ЛВП не был ассоциирован с общей смертностью, смертностью от мозгового инсульта; высокий уровень ХС ЛВП (1,7 ммоль/л) был ассоциирован с протекцией ИБС, однако очень высокий уровень ХС ЛВП (≥2,0 ммоль/л) не сопровождался снижением сердечно-сосудистых событий [9].…”

Section: инфаркт миокардаunclassified

Evaluation of the optimal values of cholesterol of high density lipoproteins in a cohort of men aged 40-59 with myocardial infarction (according to 30-year monitoring of the status of life)

Белов¹,

Меньщиков²

2019

Cardiovasc Ther Prev

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Aim. To establish connection between the functions of 30-year survival rate and concentration of cholesterol high density lipoproteins (C-HDL) in men aged 40-59 years with a past history of a myocardial infarction (MI) and relying on the obtained data to determine the optimal level of C-HDL for the specified cohort.Material and methods. The study includes 141 patients who have had MI more than 6 months ago and observed in clinics of Metallurgical district of the city of Chelyabinsk within the third group of dispensary register. Specified MI cases refer to types 1, 2 of the Third universal definition of MI. The initial stage of study of the target group of men who have a past history of MI lasted from 03.06.1974 to 24.11.1975. Observation points were 0 and 30 years. The endpoint was death. Information about the dead established during the annual monitoring of the status of life. During the observation period 130 persons/92,2% died. Evaluation of survival was carried out according to the method of Kaplan-Meier, based on which a Cox regression model was built with the inclusion of successively higher minimum level of C-HDL, so that survival curves were significantly different. 95% confidence intervals were determined. The confidence bands of survival functions were built on the basis of on non-parametric Kolmogorov-Smirnov test.Results. The analysis of the function of 30-year survival in men aged 40-59 with past history of MI, depending on the level of HDL-C showed: the presence of statistically significant relationships between survival and levels of HDL-C. Optimal concentrations of HDL cholesterol for survival were the values of HDL-C ≥2,0 mmol/l. Statistically significant periods of survival differences are shown on survival curves at different levels of HDL-C. The possibility of prediction of survival of each patient to a certain time depending on the level HDL-C is determined. Initial levels of HDL-C determine the beginning, duration, end of periods of statistically significant survival differences on survival curves.Conclusion. The analysis of 30-year monitoring of the life status of cohort of men aged 40-59 with past history of MI showed a statistically significant dependence of survival on the initial level of HDL-C. The initial concentration of HDL-C are optimal for survival of indicated cohorts of men. HDL-C levels of 2,0-2,9 mmol/l can serve as a therapeutic target for men aged 40-59 with a past history of MI. The functions of 30-year survival in the cohort of middle-aged men who underwent MI, allow to determine the probability of survival of patients with this level of HDL-C to certain time.

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“…Although subjects with very high HDL-C level are frequently observed in Japan, little is known about the atherogenicity in patients with very high HDL-C level in Japanese dwellers. In the current study, Hirata et al investigated the relationship between serum HDL categories including the very high HDL-C level ( 80 mg/dL) and all-cause/CV mortality for a long observational period from 10 to 20 years using the national cohort, surveillance study of "NIPPON DATA90" 3) . HDL-C level was not associated with all-cause mortality or stroke.…”

Section: See Article Vol 23: 800-809mentioning

confidence: 99%

Very High Levels of High-Density Lipoprotein Cholesterol and Cardiovascular Events in Japanese Population

Masuda

Yamashita

2016

JAT

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The Relationship between Very High Levels of Serum High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in a 20-Year Follow-Up Study of Japanese General Population

Cited by 49 publications

References 38 publications

Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men

Association of extremely high levels of high-density lipoprotein cholesterol with endothelial dysfunction in men

Evaluation of the optimal values of cholesterol of high density lipoproteins in a cohort of men aged 40-59 with myocardial infarction (according to 30-year monitoring of the status of life)

Very High Levels of High-Density Lipoprotein Cholesterol and Cardiovascular Events in Japanese Population

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