The relationship between various measures of obesity and arterial stiffness in morbidly obese patients

Nordstrand, Njord; Gjevestad, Espen; Dinh, KN; Hofsø, Dag; Røislien, Jo; Saltvedt, E.; Os, Ingrid; Hjelmesæth, Jøran

doi:10.1186/1471-2261-11-7

Cited by 71 publications

(52 citation statements)

References 45 publications

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“…In older adults, there are data that indicate increasing arterial stiffness with obesity, [7][8][9] although findings have been inconsistent across studies. [10][11][12][13] In contrast, obese children have reduced arterial stiffness compared with their normal weight peers, [14][15][16] an effect thought to result from physiological adaptation to the hyperemic state of obesity in the young. 16 Taken together these contrasting data from young and old populations suggest age-related differences in the relationship between body composition and arterial stiffness, which have not been fully explored.…”

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confidence: 99%

Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

et al. 2013

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Abstract-Obesity is a major risk factor for cardiometabolic disease, but the effect of body composition on vascular aging and arterial stiffness remains uncertain. We investigated relationships among body composition, blood pressure, age, and aortic pulse wave velocity in healthy individuals. Pulse wave velocity in the thoracic aorta, an indicator of central arterial stiffness, was measured in 221 volunteers (range, 18-72 years; mean, 40.3±13 years) who had no history of cardiovascular disease using cardiovascular MRI. In univariate analyses, age (r=0.78; P<0.001) and blood pressure (r=0.41; P<0.001) showed a strong positive association with pulse wave velocity. In multivariate analysis, after adjustment for age, sex, and mean arterial blood pressure, elevated body fat% was associated with reduced aortic stiffness until the age of 50 years, thereafter adiposity had an increasingly positive association with aortic stiffness (β=0.16; P<0.001). Body fat% was positively associated with cardiac output when age, sex, height, and absolute lean mass were adjusted for (β=0.23; P=0.002). These findings suggest that the cardiovascular system of young adults may be capable of adapting to the state of obesity and that an adverse association between body fat and aortic stiffness is only apparent in later life. (Hypertension. 2013;61:1322-1327.)

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confidence: 99%

Body Fat Is Associated With Reduced Aortic Stiffness Until Middle Age

et al. 2013

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“…Therefore, the notion of a relationship between the factors of metabolic syndrome and PWV is quite reasonable. However, an interesting finding of previous studies was that this predicted relationship was only observed in women and not in men [13,14]. In particular, the associations between PWV and BMI and HDL were the opposite, while those with BP, FBS, LDL, and triglyceride (TG) were the same among both men and women [13].…”

Section: Discussionmentioning

confidence: 88%

“…Interestingly, some studies have shown differences between men and women. In women, most risk factors for metabolic syndrome correlated with PWV, whereas no significance was found for these relationships in men [13,14]. For this study, we hypothesized that these differences are due to smoking, because there are many more male smokers than female smokers.…”

Section: Introductionmentioning

confidence: 87%

The Effects of Smoking on the Relationship Between Metabolic Syndrome and Arterial Stiffness

Kim

Wilson

Choi

et al. 2012

J UOEH

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: It has been reported that arterial stiffness assessed by pulse wave velocity (PWV) can predict cardiovascular morbidity and mortality. Metabolic syndrome and smoking are independently associated with increased risk of cardiovascular disease. The purpose of this study was to evaluate the effect of smoking on the relationship between metabolic syndrome and arterial stiffness. We retrospectively enrolled 1,530 men on whom brachial-ankle pulse wave velocity (baPWV) measurement had previously been performed as part of health screening at Kosin University Hospital. We found that PWV was positively correlated with the following variables: age (r = 0.391, P < 0.0001), systolic blood pressure (r = 0.438, P < 0.0001), diastolic blood pressure (r = 0.377, P < 0.0001), low-density lipoprotein (LDL) (r = 0.068, P = 0.008) and high-density lipoprotein (HDL) (r = 0.027, P = 0.287), whereas BMI was negatively correlated, although without statistical significance (r = -0.026, P = 0.309). Among current smokers, PWV decreased with increasing BMI (from 1,387.9 to 1,311.6), and increased with increasing HDL (from 1,342.7 to 1,385.4). On the other hand, among never smokers, PWV increased with increasing BMI (from 1,382.3 to 1,458.8), and decreased with increasing HDL (from 1,391.2 to 1,369.7). PWV was inversely associated with BMI and HDL, and these differences are likely due to smoking.

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“…The main modifiable risk factor in the development of coronary artery disease is obesity, giving it a degree of cardiovascular risk similar to that associated with hypertension, hyperlipidemia, smoking and sedentarism 4 . Currently, the main treatments available to aid weight reduction are dietary guidance, the practice of supervised physical activity and the use of anti-obesity drugs.…”

Section: Introductionmentioning

confidence: 99%