The relationship between using estrogen and/or progesterone and the risk of mammary gland hyperplasia in women: a meta-analysis

Zhang, Yan; Li, Yun-Yun; Zhou, Tao; Chen, Li-Rong; Yang, Xiaoli; Yong, Lai

doi:10.1080/09513590.2022.2076831

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…The imbalance of female/progesterone ratio is the main cause of mammary gland hyperplasia ( 38 – 41 ). The mammary gland is an important target organ for the effect of estrogen, and when estrogen secretion in the female organism is too high, it will cause the female breast tissue to be in a state of over-stimulation, and the poor physical condition will have an impact on the mammary gland, leading to MGH ( 42 , 43 ). Metabolic enzymes changed regulated by the intestinal microbiota will affect the estrogen level change, which leads to endocrine dysregulation, eventually causing MGH ( 36 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Ping

Wang

et al. 2023

Front. Endocrinol.

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BackgroundIn recent years, mammary gland hyperplasia (MGH) has been considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial. As a commonly used medicine in clinical practice, Atractylodes Macrocephala Rhizoma has good functions in regulating intestinal homeostasis. Therefore, this paper studied the effect of Atractylodes Macrocephala Rhizoma polysaccharide (AMP) on the intestinal flora of MGH rats, providing a new idea for polysaccharide treatment of MGH.Materials and methodsEighteen female SD rats were selected and randomly divided into three groups: blank control group (Con), model control group (Mod), and AMP group, six rats in each group. MGH rat models were established by estradiol-progesterone combination and treated with AMP gastric infusion. The levels of E2, P, and PRL in the serum of rats were measured, the intestinal contents were collected, and 16s rRNA high- throughput sequencing technology was analyzed the changes of intestinal flora in the MGH rats.ResultsAMP has good therapeutic effects on MGH rats, decreasing estradiol (E2) and prolactin (PRL) levels and increasing progesterone (P) levels; at the same time, it can regulate the abundance and diversity of intestinal flora of MGH rats, improve the disorder of intestinal flora caused by MGH, and change the community structure, increase the abundance of beneficial flora, and decrease the abundance of pathogenic flora.ConclusionAMP can improve the intestinal microbiological environment of MGH rats, maintain the microecological balance of intestinal microbial, and improve MGH symptoms.

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Section: Discussionmentioning

confidence: 99%

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Ping

Wang

et al. 2023

Front. Endocrinol.

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A gel plaster in the form of nipple cover: A comfortable and safe transdermal delivery method for mammary hyperplasia

Wu,

et al. 2024

International Journal of Pharmaceutics

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The relationship between using estrogen and/or progesterone and the risk of mammary gland hyperplasia in women: a meta-analysis

Cited by 2 publications

References 30 publications

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

A gel plaster in the form of nipple cover: A comfortable and safe transdermal delivery method for mammary hyperplasia

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