The relationship between urinary Tamm-Horsfall glycoprotein excretion and urinary activity of glycosidases in normal pregnancy and pre-eclampsia

Neßelhut, Thomas; Rath, Werner; Grunow, Elke; Kaufholz, Gesa; Ostermai, U.; Cillien, N.; Kuhn, Walther

doi:10.1016/0028-2243(93)90049-i

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…One study has found the product enzyme was involved in immune function and played a role in T cell activation [38]. Interestingly, another study has shown that the activity of α -mannosidase in the urine was increased in patients with severe gestational hypertension during pregnancy [39]. …”

Section: Discussionmentioning

confidence: 99%

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Meng

Groth

Quinn

et al. 2017

International Journal of Genomics

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Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing heritability. A two-stage discovery-confirmatory analysis was carried out in the Framingham Heart Study cohorts. The first stage was an exhaustive pairwise search performed in 2320 early-onset hypertensive cases with matched normotensive controls from the offspring cohort. Then, identified gene-gene interactions were assessed in an independent set of 694 subjects from the original cohort. Four unique gene-gene interactions were found to be related to hypertension. Three detected genes were recognized by previous studies, and the other 5 loci/genes (MAN1A1, LMO3, NPAP1/SNRPN, DNAL4, and RNA5SP455/KRT8P5) were novel findings, which had no strong main effect on hypertension and could not be easily identified by single-locus genome-wide studies. Also, by including the identified gene-gene interactions, more variance was explained in hypertension. Overall, our study provides evidence that the genome-wide gene-gene interaction analysis has the possibility to identify new susceptibility genes, which can provide more insights into the genetic background of blood pressure regulation.

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Section: Discussionmentioning

confidence: 99%

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Meng

Groth

Quinn

et al. 2017

International Journal of Genomics

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“…From our results, we cannot exclude a spill‐over phenomenon as the reason for the LMW protein increment. However, others have found decreased Tamm‐Horsfall protein in PE, a protein produced by tubular cells, implying tubular damage (16). Adding the excretion pattern of albumin and orosomucoid to the equation, our results indicate that glomerular damage could be due to gradually decreased size selectivity, either alone or in combination with decreased charge selectivity.…”

Section: Discussionmentioning

confidence: 99%

Excretion patterns of large and small proteins in pre‐eclamptic pregnancies

Kronborg¹,

Vittinghus

Allen³

et al. 2011

Acta Obstet Gynecol Scand

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“…The function of these proteins is still not well understood, but it is taught to be linked to the water/electrolyte balance and kidney innate immunity. Hypertension in pregnancy was associated with a decrease in the uromodulin's excretion rate [38], and the results of SUI samples also revealed that the level of uromodulin was decreased. Furthermore, UMOD can be used as a predictive factor for preeclampsia [39].…”

Section: Proteins Identifiedmentioning

confidence: 92%

Stress Urinary Incontinence: A Proteomics Overview

Mitulović¹,

Mohr²,

Koch³

2020

Lower Urinary Tract Dysfunction - From Evidence to Clinical Practice

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Proteomics research offers one strategy to elucidate the etiology of stress urinary incontinence (SUI) by identification of a significant and sufficient number of proteins, which provides the ability to avoid a preselection of candidate proteins for a possible early detection of the SUI. SUI represents both a psychological as well as an economic burden, and prevalence rates are expected to increase in the future, due to increasing of life expectancy. The classical epidemiology of SUI is well understood, with many environmental and lifestyle risk factors identified, including age, obesity, parity, vaginal delivery, and family history. Despite this, much of the etiology of SUI remains unclear, and it is difficult to predict which women are at risk. This chapter shows some results based on proteomic analysis of the urine proteome, which might give the answer to the question on pathways activated in SUI. Besides proteins originating from the blood, urine contains proteins secreted from the inner wall of the bladder and the urethra, and these proteins might explain the processes involved in genesis of SUI.

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The relationship between urinary Tamm-Horsfall glycoprotein excretion and urinary activity of glycosidases in normal pregnancy and pre-eclampsia

Cited by 8 publications

References 15 publications

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension

Excretion patterns of large and small proteins in pre‐eclamptic pregnancies

Stress Urinary Incontinence: A Proteomics Overview

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