The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori

Küçükazman, Metin; Yavuz, Bünyamin; Sacikara, Muhammed; Asiltürk, Zeliha; Ata, Naim; Ertuğrul, Derun Taner; Yalçın, Ahmet Arif; Yenigun, Ezgi Coskun; Kızılca, Güler; Okten, Heyecan; Akın, Kadir Okhan; Nazlıgül, Yaşar

doi:10.1007/s10620-008-0391-y

Cited by 47 publications

(32 citation statements)

References 14 publications

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“…Although previous studies on the association between H. pylori infection and lipid profiles showed contradictory results, there is a general agreement that H. pylori infection itself modifies serum lipid profiles (3, 4, 11-13, 19, 20). Patients infected with H. pylori showed an atherogenic lipid profile characterized by an increase in LDL cholesterol or decreased HDL cholesterol compared to uninfected patients (5, 11, 12, 19-22).…”

Section: Discussionmentioning

confidence: 90%

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Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans

et al. 2011

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This study was conducted to investigate the association between Helicobacter pylori (H. pylori) infection and the lipid profile among elderly Koreans. A total of 462 subjects (mean age 66.2 ± 7.6 yr, 84% males) who underwent health check-up were investigated. Each subject underwent gastroduodenoscopy with gastric mucosal biopsy, and H. pylori infection was determined by histopathological examination using the updated Sydney System score. The presence of H. pylori infection was significantly associated with the elevated serum levels of total cholesterol and low density lipoprotein (LDL) cholesterol (P < 0.05 for each) in univariate analysis. H. pylori infection was not associated with triglyceride and high density lipoprotein (HDL) cholesterol levels (P > 0.05 for each). After controlling confounders, multiple logistic regression analysis showed that the odds ratio of H. pylori infection for high LDL cholesterol level (> 140 mg/dL) was 3.113 (95% confidence interval, 1.364-7.018; P = 0.007). There were no significant associations between the presence of H. pylori infection and elevated total cholesterol levels (> 200 mg/dL) in this model (P = 0.586). The results of this study demonstrate that H. pylori infection is associated with the elevated serum LDL cholesterol levels in elderly Koreans, supporting the hypothesis that H. pylori plays a role in promoting atherosclerosis by modifying lipid metabolism.

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Section: Discussionmentioning

confidence: 90%

“…Thus, histological detection remains the standard for the diagnosis of H. pylori infection (23). A few studies have investigated the association between H. pylori infection and lipid profiles by histopathological examination (4). In our study, H. pylori infection was confirmed with the histopathological examination of the biopsied specimens.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans

et al. 2011

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“…Finally, as cholesterol is a key metabolite in H. pylori physiology and plays a critical role in bacterial survival within the stomach, we propose that the biological pathways involved in accumulation of this sterol or its derivatives may be attractive targets for the design of new treatments against infection. Interestingly, H. pylori -infected subjects with high serum levels of total cholesterol and low-density lipoprotein cholesterol exhibited increased gastritis scores (Kucukazman et al, 2009). It is tempting to speculate whether increased levels of cholesterol within the gastric niche of these subjects might render H. pylori bacteria more pathogenic.…”

Section: Discussionmentioning

confidence: 99%

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization

Hutton

D’Costa

Rossiter

et al. 2017

Front. Cell. Infect. Microbiol.

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The human pathogen Helicobacter pylori acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as “lipid rafts.” Incorporation of this cholesterol into the H. pylori cell membrane allows the bacterium to avoid clearance by the host immune system and to resist the effects of antibiotics and antimicrobial peptides. The presence of cholesterol in H. pylori bacteria suggested that this pathogen may have cholesterol-enriched domains within its membrane. Consistent with this suggestion, we identified a hypothetical H. pylori protein (HP0248) with homology to the flotillin proteins normally found in the cholesterol-enriched domains of eukaryotic cells. As shown for eukaryotic flotillin proteins, HP0248 was detected in detergent-resistant membrane fractions of H. pylori. Importantly, H. pylori HP0248 mutants contained lower levels of cholesterol than wild-type bacteria (P < 0.01). HP0248 mutant bacteria also exhibited defects in type IV secretion functions, as indicated by reduced IL-8 responses and CagA translocation in epithelial cells (P < 0.05), and were less able to establish a chronic infection in mice than wild-type bacteria (P < 0.05). Thus, we have identified an H. pylori flotillin protein and shown its importance for bacterial virulence. Taken together, the data demonstrate important roles for H. pylori flotillin in host-pathogen interactions. We propose that H. pylori flotillin may be required for the organization of virulence proteins into membrane raft-like structures in this pathogen.

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“…Some infectious diseases, such as Chlamydia pneumoniae infection, have been considered as risk factors for coronary heart disease (18), and several studies have pointed to an association between H. pylori infection and vascular changes due to the alteration of the serum lipid profile (19,38). Previous studies reported that the serum T-Chol, TG, or LDL concentrations in H. pylori-infected persons are significantly elevated over those in noninfected individuals (39,40). On the other hand, several authors described HDL cholesterol levels to be decreased by longterm infection with H. pylori (41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

Pitavastatin Fails to Lower Serum Lipid Levels or Inhibit Gastric Carcinogenesis in Helicobacter pylori–Infected Rodent Models

Toyoda

Tsukamoto²,

Takasu

et al. 2009

Cancer Prevention Research

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Statins are commonly used lipid-lowering drugs that reduce the risk of cardiovascular morbidity and mortality. Although recent studies have pointed to chemopreventive effects of statins against various cancers, their efficacy for gastric cancer is unclear. Here, we examined the effects of pitavastatin, a lipophilic statin, on Helicobacter pylori (H. pylori)-associated stomach carcinogenesis and gastritis using Mongolian gerbil and mouse models. The animals were allocated to H. pylori + N-methyl-N-nitrosourea administration (gerbils, 52 weeks) or H. pylori infection alone groups (gerbils and mice, 12 weeks). After H. pylori infection, they were fed basal diets containing 0 to 10 ppm of pitavastatin. The incidences of H. pylori-associated gastric adenocarcinomas and degrees of chronic gastritis were not decreased by pitavastatin compared with those of control values. Expression of interleukin-1β and tumor necrosis factor-α mRNAs in the pyloric mucosa was markedly up-regulated in pitavastatin-treated animals. Furthermore, in the H. pyloriinfected groups, serum total cholesterol, triglyceride, and low-density lipoprotein levels were significantly increased by pitavastatin treatment, contrary to expectation. In the short-term study, H. pylori-infected gerbils and mice also showed significant up-regulation of serum triglyceride levels by pitavastatin, whereas total cholesterol was markedly reduced and low-density lipoprotein exhibited a tendency for decrease in noninfected animals. These findings indicate pitavastatin to be ineffective for suppressing gastritis and chemoprevention of gastric carcinogenesis in H. pylori-infected gerbils. Our serologic results also suggest that the H. pylori infection and consequent severe chronic gastritis interfere with the cholesterol-lowering effects of pitavastatin.

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The Relationship Between Updated Sydney System Score and LDL Cholesterol Levels in Patients Infected with Helicobacter pylori

Abstract: Increased levels of TC and LDL-C were found in patients infected with H. pylori, and updated Sydney System score showed a positive correlation with LDL-C and TC levels. These findings may explain why H. pylori infection is associated with increased risk of atherosclerosis.

Cited by 47 publications

References 14 publications

Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans

Helicobacter pylori Infection is Associated with Elevated Low Density Lipoprotein Cholesterol Levels in Elderly Koreans

A Helicobacter pylori Homolog of Eukaryotic Flotillin Is Involved in Cholesterol Accumulation, Epithelial Cell Responses and Host Colonization

Pitavastatin Fails to Lower Serum Lipid Levels or Inhibit Gastric Carcinogenesis in Helicobacter pylori–Infected Rodent Models

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