The relationship between trace elements and cardiac markers in acute coronary syndromes

Altekin, Emel; Çöker, Canan; Şişman, Ali Rιza; Onvural, Banu; Kuralay, Filiz; Kırımlı, Önder

doi:10.1016/j.jtemb.2004.12.002

Cited by 79 publications

(63 citation statements)

References 48 publications

(45 reference statements)

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“…In a study performed in patients with acute coronary syndrome, by Altekin et al [26], a relationship between cardiac markers and trace elements was found. A positive correlation between serum Cu levels with elevated troponin T, troponin I, and CK-MB values (≥0.9, ≥1.0, and ≥30 ng/ml, respectively) and a negative correlation between troponin T and Zn were found.…”

Section: Discussionmentioning

confidence: 96%

The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis

İslamoğlu

Evliyaoğlu

Tekbaş

et al. 2011

Biol Trace Elem Res

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The essential trace elements play important roles in the maintainance of the normal structure and physiology of cells. Several research groups have demonstrated that they also play important roles in states of cardiovascular diseases. Our aim is to investigate whether there is a relationship between trace elements (Zn and Cu) and the degree of atherosclerosis. The sample consisted of 67 patients with coronary artery disease and 26 clinically healthy individuals. Ninety-three subjects were separated into four groups according to their Gensini scores, the number of diseased vessels, the presence of acute coronary syndrome, and ejection fraction. Each group was divided into three subgroups, and serum zinc and copper levels were measured for each individual. The serum levels of zinc and copper were found to be significantly lower in patients with atherosclerosis than in the control group, but there were no significant differences in the serum levels of Cu and Zn between severe atherosclerosis and mild atherosclerosis. In Spearman's rank correlation, the zinc and copper levels were correlated with the Gensini score and the number of diseased vessels. The present study revealed a relationship between the serum levels of zinc and copper and atherosclerosis, but not between these levels and the severity of the disease.

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Section: Discussionmentioning

confidence: 96%

The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis

İslamoğlu

Evliyaoğlu

Tekbaş

et al. 2011

Biol Trace Elem Res

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“…It provided from Bioassay Technology Laboratory (Shanghai Crystal Day Biotech Co., LTD, China). The metabolic syndrome diagnostic criteria were used as suggested by ATP III (Adult Treatment Panel III) (Altekin et al, 2005), including: (1) Waist circumference >102 cm in men and >88 cm in women, (2) Serum triglycerides level $150 mg dLG 1 , (3) Low HDL-cholesterol: < 40 mg dLG 1 in men and <50 mg dLG 1 in women, (4) Systolic Blood Pressure (SBP) $130 mmHg and/or Diastolic Blood Pressure (DBP) $85 mmHg or on treatment for hypertension and (5) Serum glucose level $110 mg dLG 1 or on treatment for diabetes. Subjects with any 3 or more of the above mentioned criteria specified as a metabolic syndrome subject.…”

Section: Methodsmentioning

confidence: 99%

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Shafaei¹,

Khoshnia²,

Marjani³

2015

J. of Medical Sciences

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Effect of FGF21 on metabolic syndrome patients is not exactly clear. In the present study, we assessed serum level of fibroblast growth factor 21 in type 2 diabetic patients with and without metabolic syndrome in Gorgan. The study groups consisted of 120 patients with type 2 diabetes and 60 healthy subjects. Diabetic patients divided into two groups. All subjects were matched according to age and sex. The mean waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose levels and body mass index were significantly higher in the subjects with metabolic syndrome than control group, but the mean HDL-cholesterol was significantly lower (p = 0.0001). Mean serum level of FGF21 was higher in type 2 diabetic subjects with and without metabolic syndrome than that of control subject (p = 0.0001). There were significant negative correlation between FGF21 and BMI, diastolic blood pressure and HDL-cholesterol in subjects with metabolic syndrome (p<0.05). There were also significant negative correlation between FGF21 and cholesterol and HDL-cholesterol in control group (p<0.05). The findings of this study suggest that serum FGF21 are higher in patients with type 2 diabetes with and without metabolic syndrome than in age and sex matched control group. Our study shows that some of metabolic syndrome components (especially HDL-cholesterol) are associated with high serum FGF21 levels. Because of different effects of FGF21 in rodents, primates and in humans, it may require more investigating on metabolic effects of FGF21 in human's samples.

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“…34 Serum glutathione peroxidase (GPX) is a protein with Se at the active site, and GPX activity was negatively associated with prognostic markers of acute cardiac syndrome (ACS) in ACSdiagnosed individuals. 35 C-reactive protein (CRP), a non-specific marker of inflammation, was associated with decreased serum Se concentrations in adults. 36 Increased Se status is associated with decreased use of corticosteroids in corticoid-dependent asthmatics, 128 130 {Willett, 1983 53498/id) and incidence of inflammatory Behcet's disease 38 and severe rheumatoid arthritis.…”

mentioning

confidence: 99%

Increased intakes of selenium‐enriched foods may benefit human health

Finley¹

2007

J Sci Food Agric

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The relationship between trace elements and cardiac markers in acute coronary syndromes

Cited by 79 publications

References 48 publications

The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis

The Relationship Between Serum Levels of Zn and Cu and Severity of Coronary Atherosclerosis

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Increased intakes of selenium‐enriched foods may benefit human health

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