The Relationship Between the Three‐Dimensional (3D) Structures of <scp>BF</scp> Molecules and <scp>MHC</scp>‐Related Marek's Disease Resistance in Chickens

Jin, Yuanchang; Wei, Ping; Cui, Shengyan; Huang, Lida

doi:10.1111/sji.12278

Cited by 1 publication

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“…NRAMP-1 and iNOS genes are included in the natural immune system that is genetic. Several studies have revealed the association between NRAMP-1 and iNOS genes against disease resistance, including the associations with tuberculosis in humans (Medapati et al, 2017;Mahmud et al, 2017), salmonella disease in mice (Bauler et al, 2017;Reventun et al, 2017), tuberculosis in cattle (Pereira-Suárez et al, 2006;Delgado et al, 2010), the nature of immunity in pigs (Dai et al, 2017;Yan et al, 2017), Rhodococcus equi pneumonia in horses (Halbert et al, 2006), salmonella and viruses in goats and sheep (Lantier et al, 2012;Dincel & Kul, 2015;), and S. enteritidis in chickens (Kramer et al, 2003;Tohidi et al, 2013;Jin et al, 2015;Psifidi et al, 2016;Sun et al, 2017).…”

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confidence: 99%

Polymorphisms and Associations of the NRAMP-1 and iNOS Genes on Newcastle Disease and Salmonella enteritidis Resistances in SenSi-1 Agrinak Chickens

Ardiyana

Gunawan

Murtini

et al. 2020

Trop. Anim. Sci. J.

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NRAMP-1 and iNOS genes were reported to be associated with a defense mechanism against bacteria and virus infections. This study aimed to identify NRAMP-1 and iNOS genes polymorphisms and their associations with the defense mechanisms against Salmonella enteritidis and Newcastle Disease (ND) in SenSi-1 Agrinak chicken. The present study used a total number of 172 SenSi-1 Agrinak chicken. Identifications of NRAMP-1 and iNOS genes polymorphisms were performed by PCR-RFLP method. NRAMP-1 and iNOS genotypes were associated with immunoglobulin Y (IgY) concentration, specific antibodies against S. enteritidis and ND using General Linear Model (GLM). Immunity characteristics were further grouped into high, medium, and low categories. NRAMP-1|SacI exon 11 and iNOS|AluI intron 24 in SenSi-1 Agrinak chickens were polymorphic. TC genotype has a higher immune response to infectious agents compared to TT and CC genotypes. The frequency of C allele was higher than the T allele in the concentration of immunoglobulin Y (IgY), antibodies titers against S enteritidis and ND. The TC genotype of NRAMP-1 gene was significantly associated with ND antibody titers, and the TT genotype of iNOS was significantly associated with S. enteritidis specific antibody. NRAMP-1 and iNOS genes can be used as potential candidate genes for immune traits in SenSi-1 Agrinak chickens.

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