The relationship between the stromal mast cell number, microvessel density, c-erbb-2 staining and survival and prognostic factors in colorectal carcinoma

Elezoglu, Bahar; Tolunay, Şahsine

doi:10.5146/tjpath.2012.01109

Cited by 10 publications

(8 citation statements)

References 18 publications

(19 reference statements)

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“…Literature searches yield 11,417 records and the results were shown in Figure S1. Twenty eight studies containing 4,224 patients with solid tumor were identified for the assessment of tumor‐infiltrating tryptase + mast cells . All the studies were evaluated by the Newcastle–Ottawa Scale (NOS), and were in accordance with the inclusion criteria and suitable for data consolidation.…”

Section: Resultsmentioning

confidence: 99%

Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors

Wang

Cheng

2017

Intl Journal of Cancer

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The prognostic role of tumor-infiltrating tryptase mast cells in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 28 published studies with 4224 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating tryptase mast cells in human solid tumors. We found that tryptase mast cell infiltration significantly decreased overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, tryptase mast cell infiltration was significantly associated with worse OS in non-small cell lung cancer, hepatocellular carcinoma and 5-year survival in colorectal cancer. And these cells were inversely associated with DFS in hepatocellular and colorectal cancer. In addition, high density of intratumoral tryptase mast cells significantly correlated with lymph node metastasis of solid tumor. In conclusion, Tryptase mast cell infiltration leads to an unfavorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances and targeting it may have a potential for effective treatment.

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Section: Resultsmentioning

confidence: 99%

Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors

Wang

Cheng

2017

Intl Journal of Cancer

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“…For each case, the peritumoral LVD (P‐LVD; hotspots selected in the peripheral tissues within 2 mm of the tumor margins) and intratumoral LVD (I‐LVD; hotspots located within the tumor and surrounded by tumor cells) were calculated separately [20,22,23]. MCs were counted in intratumoral (I‐MCD), peritumoral (P‐MCD), and nontumoral breast (NTB‐MCD; outside of the peritumoral area) tissues [20,21]. In lymph node slides, the area surrounded by a lymph node capsule was taken into account [21].…”

Section: Methodsmentioning

confidence: 99%

“…MCs were counted in intratumoral (I‐MCD), peritumoral (P‐MCD), and nontumoral breast (NTB‐MCD; outside of the peritumoral area) tissues [20,21]. In lymph node slides, the area surrounded by a lymph node capsule was taken into account [21].…”

Section: Methodsmentioning

confidence: 99%

“…Each case was evaluated for age, tumor size, tumor volume, tumor type, histological grade, nuclear grade, axillary lymph node involvement, lymphovascular invasion (LVI, in hematoxylin ‐ and ‐ eosin‐stained slides), lymphatic invasion (LI, in D2‐40‐stained slides), perineural invasion (PI), estrogen receptor (ER), progesterone receptor (PR), and C‐erbB2 staining. Clinicopathological classification and staging were assessed according to the American Joint Committee on Cancer criteria [20–25]. The clinical features of recurrence, metastasis, and death from disease were acquired from patient records.…”

Section: Methodsmentioning

confidence: 99%

“…The method for quantifying MCD and LVD followed that reported previously [1,10,12,14,20–23]. The sections stained with toluidine blue and D2‐40 were first scanned at low magnification (100×) to select ten hotspots in each tumor [20,23].…”

Section: Methodsmentioning

confidence: 99%

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Relationship of mast cell density with lymphangiogenesis and prognostic parameters in breast carcinoma

Keser

Kandemır

Ece

et al. 2017

The Kaohsiung J of Med Scie

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In many cancers, mast cell density (MCD) in the tumor microenvironment is associated with tumor progression and, to a greater extent, angiogenesis. Our study was designed to investigate the correlation between MCD, tumor lymphangiogenesis, and several well-established prognostic parameters in breast cancer. One hundred and four cases of invasive breast carcinoma diagnosed in our clinic between 2007 and 2011 were included. Mast cells and lymphatic vessels were stained with toluidine blue and D2-40, respectively, and their densities were calculated in various areas of tumors and lymph nodes. The variables of MCD and lymphatic vessel density (LVD) were compared using prognostic parameters as well as with each other. As tumor size and volume increased, MCD increased comparably in metastatic lymph nodes; intratumoral and peritumoral LVD also increased. Lymphovascular invasion, lymphatic invasion, perineural invasion, and estrogen receptor positivity were positively related to intratumoral MCD. The relationship between peritumoral MCD and nontumoral breast tissue MCD was statistically significant. Stage was correlated with MCD in metastatic lymph nodes. Metastatic lymph node MCD and intratumoral MCD were also significantly related. Stage, lymphatic invasion, perineural invasion, lymphovascular invasion, and metastatic lymph node MCD were all correlated with intratumoral and/or peritumoral LVD. As nuclear grade increased, intratumoral LVD became higher. In breast carcinoma, MCD, depending on its location, was related to several prognostic parameters. Notably, mast cells may have at least some effect on lymphangiogenesis, which appears to be a predictor of tumor progression.

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Mast Cells in the Tumor Microenvironment

Aponte-López

Muñoz-Cruz

2020

Advances in Experimental Medicine and Biology

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The relationship between the stromal mast cell number, microvessel density, c-erbb-2 staining and survival and prognostic factors in colorectal carcinoma

Cited by 10 publications

References 18 publications

Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors

Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors

Relationship of mast cell density with lymphangiogenesis and prognostic parameters in breast carcinoma

Mast Cells in the Tumor Microenvironment

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The relationship between the stromal mast cell number, microvessel density, c-erbb-2 staining and survival and prognostic factors in colorectal carcinoma

Cited by 10 publications

References 18 publications

Tumor‐infiltrating tryptase+ mast cells predict unfavorable clinical outcome in solid tumors

Tumor‐infiltrating tryptase+ mast cells predict unfavorable clinical outcome in solid tumors

Relationship of mast cell density with lymphangiogenesis and prognostic parameters in breast carcinoma

Mast Cells in the Tumor Microenvironment

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Product

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Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors

Tumor‐infiltrating tryptase⁺ mast cells predict unfavorable clinical outcome in solid tumors