The relationship between the severity of coronary artery disease and skin measurement parameters

Abstract

Purpose This study aimed to investigate the relationship between skin parameters and CAD. Materials and Methods The study included 50 patients diagnosed with coronary artery disease as the patient group and 45 volunteers without any known coronary artery disease as the control group. The participants' skin TEWL, pH, temperature, electrical capacitance, sebum, and elasticity values were measured using noninvasive methods at the forehead, back, and forearm. Findings Skin temperature was significantly higher in the back and forehead regions in the patient group. No difference was found between the sebum values of the patient and control groups at the back and forehead. A significantly higher result was obtained for the forearm area. The pH was significantly lower in the patients' forearm, although the obtained values were within the normal range. The TEWL was significantly higher in patients in all three regions. In terms of flexibility, R2 was significantly higher in the back and forehead regions of the patient group, and the R6 was significantly higher in the patient group in all three regions. In addition, there was no correlation between skin parameter and SYNTAX score increase measurements. Conclusion It can be suggested that skin sebum and TEWL measurements can be accepted as cheap and noninvasive methods of predicting CAD.

“Normal” TEWL‐how can it be defined? A systematic review

“…Coronary artery disease may also disrupt skin barrier integrity in patients, as studied by Öksüm Solak et al 31 Fifty patients diagnosed with coronary artery disease via angiography were compared with 45 healthy volunteers aged 18 years or older 31 . Patients were excluded if they had a history of dermatological conditions that may affect TEWL measurements 31 .…”

“…Coronary artery disease may also disrupt skin barrier integrity in patients, as studied by Öksüm Solak et al 31 Fifty patients diagnosed with coronary artery disease via angiography were compared with 45 healthy volunteers aged 18 years or older 31 . Patients were excluded if they had a history of dermatological conditions that may affect TEWL measurements 31 . The Tewameter TM210 was used to make TEWL measurements on the forehead, forearm and back after subjects rested for 30 min in a 21‐degree Celsius room in humidity from 40% to 45% 31 .…”

“…Patients were excluded if they had a history of dermatological conditions that may affect TEWL measurements 31 . The Tewameter TM210 was used to make TEWL measurements on the forehead, forearm and back after subjects rested for 30 min in a 21‐degree Celsius room in humidity from 40% to 45% 31 . Results showed that TEWL measurements were significantly higher in patients with coronary artery disease compared with controls in all three regions 31 …”

Improvement in Cutaneous Conditions Can Benefit Some Health Conditions in the Elderly

“…Transepidermal water loss rates, an indicator of epidermal permeability, are 23% higher in individuals with coronary artery disease than in those without coronary artery disease. 78 Elevated transepidermal water loss rates and reduced stratum corneum hydration levels have been observed in individuals with type 2 diabetes. 79 Individuals with obesity also exhibit higher transepidermal water loss rates than normal controls (14.27 ± 4.4 vs 11.3 ± 2.7, p < 0.05).…”

Analisis Kelembapan Kulit pada Pasien Anak dengan Penyakit Jantung Bawaan Di RSUDZA Banda Aceh

“…Pada penelitian sebelumnya yang dilakukan oleh Solak et al pada tahun 2020 menyatakan bahwa terjadi peningkatan TEWL pada pasien dengan penyakit jantung korener, Majewski et al juga menunjukkan bahwa Scap dan TEWL dapat menjadi indikator dalam melihat kondisi kulit pada pasien dengan penyakit paru obstruksi kronis (PPOK) sehingga pengukuran TEWL dan Scap dapat diterima sebagai metode yang murah dan non-invasif untuk memprediksi penyakit jantung koroner (Majewski et al, 2017;Öksüm Solak et al, 2021). Sejauh pencarian literatur kami, sampai saat ini belum ada laporan mengenai status kelembapan kulit pada pasien anak dengan PJB.…”