The relationship between the serum level of CD40 ligand and persistent lone atrial fibrillation

Bozçalı, Evin; Polat, Veli; Kutlu, Gönül; Opan, Selçuk; Paker, Nurcan; Uygun, Turgut; Ökçün, Barış; Karakaya, Osman

doi:10.5543/tkda.2016.03061

Cited by 4 publications

(5 citation statements)

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“…Regular clinical follow-up is required in the studied subjects because of the increased risk of CVDs, which is determined by increased CD40L levels. 19 …”

Section: Methodsmentioning

confidence: 99%

“…Regular clinical follow-up is required in the studied subjects because of the increased risk of CVDs, which is determined by increased CD40L levels. 19 Blann et al's study determined that sCD40L levels were marginally elevated in AF patients relative to levels of P-selectin as well as von Willebrand factor. 20 Similarly, Hammwöhner et al's study investigated atrial clot development in persistent AF patients, revealing the consequence of platelet CD40L expression and its relationship with inflammatory markers.…”

Section: Role Of Major Inflammatory Biomarkers In Atrial Fibrillationmentioning

confidence: 99%

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The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

RAFAQAT¹,

AFZAL²,

KHURSHID³

et al. 2022

J Innov Cardiac Rhythm Manage.

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Many studies have reported a relationship between inflammation and atrial fibrillation (AF). According to the literature, inflammation is the key component in pathophysiological processes during the development of AF; the amplification of inflammatory pathways triggers AF, and, at the same time, AF increases the inflammatory state. The plasma levels of several inflammatory biomarkers are elevated in patients with AF; therefore, inflammation might contribute to both the maintenance and occurrence of AF and its thromboembolic complications. Numerous inflammatory markers have been linked to AF, including CD40 ligand, fibrinogen, matrix metalloproteinase (MMP)-9, monocyte chemoattractant protein-1, myeloperoxidase, plasminogen activator inhibitor-1, and serum amyloid A. There are many pathophysiological aspects of AF that are linked to these inflammatory biomarkers, including atrial structural remodeling and atrial dilatation, increased atrial myocyte expression, fluctuations in calcium cycling, cardiac remodeling promotion, increased cardiac myocyte proliferation and terminal differentiation, production of several MMPs, the pathogenesis of atherosclerosis and cardiomyocyte apoptosis, an increased degree of fibrosis in atrial myocardium, and the progression and development of atherogenesis and atherothrombosis. The present review article aims to provide an updated overview and focus on the basic role of different biomarkers of inflammation in the pathophysiological aspects of the pathogenesis of AF.

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“…Regular clinical follow-up is required in the studied subjects because of the increased risk of CVDs, which is determined by increased CD40L levels. 19 …”

Section: Methodsmentioning

confidence: 99%

Section: Role Of Major Inflammatory Biomarkers In Atrial Fibrillationmentioning

confidence: 99%

The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

RAFAQAT¹,

AFZAL²,

KHURSHID³

et al. 2022

J Innov Cardiac Rhythm Manage.

View full text Add to dashboard Cite

show abstract

“…8 CD40 ligand is considered a part of the tumor necrosis factor family. 8,9 CD40-L has been observed on the surface of many cell lineages including monocytes, macrophages, neutrophils, smooth muscle cells, endothelial cells, and platelets. 10 Recent research has shown that CD40-L expressed on the surface of platelets mediates inflammatory and thrombogenic pathways in the body.…”

Section: Introductionmentioning

confidence: 99%

Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation

Otto

Fareed

Liles

et al. 2018

Clin Appl Thromb Hemost

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This study aims to examine the effects of atrial fibrillation (AF) on the expression of the cellular mediators plasminogen activator inhibitor 1 (PAI-1) and CD40 ligand (CD40-L). Additionally, the effect of catheter ablation on the levels of the aforementioned biomarkers was also examined. In this prospective study, plasma samples were collected from patients with AF at baseline prior to ablation and at 1 and 3 months postablation. There was a statistically significant increase in CD40-L at baseline in patients with AF compared to control ( P = .0034). There was a statistically significant decrease in CD40-L levels postablation at both 1 month ( P < .0001) and 3 months ( P < .0001) compared to baseline. Baseline levels of PAI-1 were elevated compared to the control group (mean 19.55 ± 2.17 ng/mL vs 4.85 ± 0.41 ng/mL) and a statistically significant decrease in circulating PAI-1 levels 1 month postablation ( P = .05) was noted compared to preablation levels. These data suggest that inflammation plays an important role in the pathogenesis of AF and that these cellular mediators are modulated by catheter ablation.

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“…[14] Bozçalı ve ark.nın Türk Kardiyoloji Derneği Arşivi'nin bu sayısında yayınla-nan çalışmasında sadece ısrarcı tek başına AF hastaları incelemeye dahil edilmiş ve CD40L ve CRP düzeyle-ri AF grubunda sağlıklı kontrol grubuna göre anlamlı derecede daha yüksek saptanmıştır. [15] Sadece ısrarcı tek başına AF'li hastaların çalışmaya dahil edilmesi, AF'yi etkileyebilecek sistemik ve yapısal hastalıklar-dan sıyrılmış nispeten saf bir hasta grubunu ele alarak enflamatuvar ve protrombotik süreci etkilemesi olası birçok faktörün ekarte edilmesi bakımından önemlidir. Çalışmada, AF ve kontrol grupları arasındaki, belirteç düzeylerini etkilemesi olası lipit, kan şekeri düzeyleri, kan basıncı, sigara kullanımı açısından da fark saptanmamıştır.…”

unclassified

“…[15] Bu bulgu, her ne kadar nispeten saf bir hasta popülasyonundan elde edilmiş olsa da, karmaşık bir patofizyolojiye sahip bir hastalıkta CD40L düzeylerinin güncel pratikte bir tarama veya tanı testi olarak kullanılması henüz mümkün gö-zükmemektedir.…”

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Serum CD40 ligand levels and persistent lone atrial fibrillation

Altın¹

2016

Arch Turk Soc Cardiol

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The relationship between the serum level of CD40 ligand and persistent lone atrial fibrillation

Abstract: The present findings suggest that CD40L levels play a crucial role in the development of lone atrial fibrillation. In addition, results support that regular clinical follow-up of these patients is necessary, due to increased cardiovascular disease risk, determined by elevated CD40L levels.

Cited by 4 publications

References 0 publications

The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

The Role of Major Inflammatory Biomarkers in the Pathogenesis of Atrial Fibrillation

Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation

Serum CD40 ligand levels and persistent lone atrial fibrillation

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