The relationship between the parenteral dose of fish oil supplementation and the variation of liver function tests in hospitalized adult patients

Abstract

BackgroundHepatic dysfunction is a complication associated with parenteral nutrition (PN). Our primary objective was to study the relationship between doses of intravenous fish oil (FO) emulsion in PN and the variation in the main liver function tests (LFTs) in hospitalized PN-treated adults. As a secondary objective, we studied the safety of FO administration.MethodsWe conducted a retrospective study in adult patients receiving FO supplementation in PN. Demographic, nutritional and safety variables were collected. Variation of LFTs was defined as the difference between values just before the first administration of FO and values at the end of PN. A multiple linear regression was performed to study the association between PN-lipids (FO or vegetable) and the variation of each LFT; the following variables were used to adjust the effect of lipids: sepsis, length of stay in the intensive care unit and lipids dose. Student t-test was used to study safety variables. Data were analyzed using SPSS 19.0.ResultsPatients (53, median age 68 years (24–90); 62 % men) with the principal diagnosis of digestive neoplasm (42 %) received PN for a median of 19 (7–75) days. In the multivariate analysis, the amount of FO was related to a decrease in gamma-glutamyl transferase (GGT) (B = −2.23;CI95 % = −4.41/-0.05), a decrease in alkaline phosphatase (AP) (B = −1.23;CI95 % = −2.07/-0.37), and a decrease in alanine aminotransferase (ALT) (B = −0.82; CI95 % = −1.19/-0.44). No differences were found in safety variables.ConclusionsGGT, AP and ALT improved with FO PN-supplementation. Moreover, the improvement was greater when the doses of FO were higher. FO administration in PN is safe.

Protective Effects of Fish Oil Omega-3 Supplement on Liver-related Biochemical Factors Changes Induced by Thioacetamide in Male Rats

“…In addition, EPA reduces levels of TNF-a and IL-6 in the hepatocytes 32 ,and DHA improves hepatic injuries induced by valproate through reforming of oxidative stresses and inflammation without having any effect on plasma level of valproate 33 .Moreover, it has been shown that addition of fish oil supplement to parental diet reforms the increased levels of hepatic enzymes resulted from hepatic mal-function related to parental nutrition 34 .Studies have shown that 10% fish oil and 1 g% artichoke leaf can restore hepatocellular carcinoma in rats 35 . Lee et al (2008) determined that Omega-3 fatty acid can repair hepatocellular damage caused by obstruction of the bile ducts 36 ; it was also shown that fish oil along with allopurinol And verapamil improve hepatic injuries resulting from ischemia by a significant reduction in oxidative stress and hepatic enzymes 37 .In a study by Mardones et al (2012), it was demonstrated that combination of thyroid hormone and fish oil protocol prevents liver damage resulted from tissue injury and ischemia 38 .Furthermore, Omega-3 fatty acid prevents acute liver defects and stimulates liver regeneration following 90% hepatectomy in rats 39 .…”

Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats

“…In addition, EPA reduces levels of TNF-a and IL-6 in the hepatocytes [33], and DHA improves hepatic injuries induced by valproate through reforming of oxidative stresses and inflammation without having any effect on plasma level of valproate [34]. Moreover, it has been shown that addition of fish oil supplement to parental diet reforms the increased levels of hepatic enzymes resulted from hepatic mal-function related to parental nutrition [35]. Studies have shown that 10% fish oil and 1 g% artichoke leaf can restore hepatocellular carcinoma in rats [36].…”