The Relationship between the Localization, Size, Stage and Histopathology of the Primary Laryngeal Tumor with Neck Metastasis

Mutlu, Vahit; Üçüncü, Neslihan; Altaş, Enver; Aktan, Bülent

doi:10.5152/eajm.2014.01

Cited by 11 publications

(10 citation statements)

References 26 publications

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“…During surgery, the safe margin is determined based on the surgeon's experience, visual review, finger palpation, and pathological assessment of frozen sections. Despite these efforts, there is still a 10%‐30% local recurrence rate . Tools to improve the real‐time assessment of tumor margins during surgery could decrease the local recurrence rate of oral cancer.…”

Section: Introductionmentioning

confidence: 99%

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Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

et al. 2018

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Background The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near‐infrared fluorescence‐guided oral cancer surgery. Methods Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal‐to‐background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Results The greatest contrast in the fluorescence intensity between tumor and normal tissue was observed at 6 hours (P < .01), and of three dose groups (0.5, 0.75, and 1.0 mg/kg), 0.75 mg/kg showed the highest SBR (2.06 ± 0.23) after ICG injection. Conclusions Fluorescence quantification based on spectrometry and grayscale imaging could be effective in determining the optimal ICG dose and surgical time after ICG injection in this cohort of patients with oral cancer.

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Section: Introductionmentioning

confidence: 99%

“…Despite these efforts, there is still a 10%-30% local recurrence rate. 5 Tools to improve the real-time assessment of tumor margins during surgery could decrease the local recurrence rate of oral cancer.…”

mentioning

confidence: 99%

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

et al. 2018

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“…It has been shown that supraglottic laryngectomy is an effective approach for supraglottic carcinoma in the early stages, while radiotherapy is an accepted alternative to surgery in early stage disease, especially in elderly and multimorbid patients with pulmonary dysfunction, because of significant morbidity and postoperative functional problems after classic partial supraglottic laryngectomy (Canis et al, 2013). In N0 patients with laryngeal cancer, unilateral or bilateral elective neck dissection should be performed according to the anatomical location and histopathological specimens should be taken in the event of positive detection of metastases concluding that postoperative radiotherapy should be performed (Mutlu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Management of clinically negative nodes (N0) in supraglottic laryngeal carcinoma: A systematic review

Liu

2016

Genet. Mol. Res.

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ABSTRACT. The purpose of this study was to evaluate the treatment of clinically negative cervical lymph nodes in supraglottic carcinoma by a meta-analysis. The search words were "supraglottic carcinoma", "cervical lymph nodes negative/cN0", "radical neck dissection", and "radiotherapy". The databases included the Chinese biomedical literature database, Medline, Cochrane library, EMBASE database, journals, and theses, etc. from 1989 onwards. Using the 5-year overall survival, disease-free survival, and disease-specific survival rates, and the recurrence and distant metastasis rates as observation indexes, the proper model and method were selected after a heterogeneity test to allow combined statistic tests, sensitivity analysis, and publication bias analysis to be conducted. Four studies (807 cases) were included in the analysis. Comparisons of the 5-year overall survival, diseasefree survival, and disease-specific survival rates as well as lymph node metastasis and the recurrence rate for radical neck dissection and radiotherapy showed no significant differences. There was no advantage of radical neck dissection in supraglottic carcinoma with clinically negative cervical lymph nodes compared to radiotherapy. However, owing to the lack of a prospective study and large number of cases, selection bias and measurement bias may still exist.

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“…However, to put a certain concern, the number of glottic cancers was very low in this study as well the others. 2 A total of 38 head and neck cancer patients (16 oropharynx, 2 hypopharynx, 8 preoral cavities, and 12 larynx cancers) were evaluated and clinically diagnosed as N0 with USG and CT. In sentinel lymph node, biopsies that were taken intraoperatively were detected as positive in five patients including two glottic larynx carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Lymph Node Involvement in T1a Glottic Carcinoma: Controversial Case Series

Yalçınozan

Şafak

2020

Asian Journal of Oncology

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The treatment modality of laryngeal cancer is complete resection of the primary lesion and dissection of the cervical lymph nodes that is related to their staging. Following the patient without neck dissection is the usual expectation in T1 glottic carcinomas. However, a combination of elective neck dissection with surgical treatment for clinically N0 neck in early glottic tumors may be an effective treatment modality in the prevention of missed micrometastases. In these two case reports, elective neck dissection and re-examination of the treatment were discussed accordingly. We aimed to point out the importance of evaluation, examination, and, if it is uncertain, moreover the dissection of lymph nodes in early-stage glottic carcinoma since there are rarely any studies available.

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The Relationship between the Localization, Size, Stage and Histopathology of the Primary Laryngeal Tumor with Neck Metastasis

Cited by 11 publications

References 26 publications

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image‐guided oral cancer surgery applications

Management of clinically negative nodes (N0) in supraglottic laryngeal carcinoma: A systematic review

Lymph Node Involvement in T1a Glottic Carcinoma: Controversial Case Series

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