The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma

Natarajan, Sushiladevi; Free, Robert C; Bradding, Peter; McGarvey, Lorcan; Siddiqui, Salman

doi:10.1186/s12931-017-0520-2

Cited by 20 publications

(13 citation statements)

References 20 publications

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“…In a recent study of 89 patients with physician-diagnosed asthma, objectively measured cough frequency showed a good correlation with asthma control, but not with airway obstruction or inflammation 87. In another study of 262 adult patients with severe asthma, the LCQ score only showed moderate correlations with asthma control status, but not with sputum eosinophils (%) 88. Also, in a study using capsaicin cough challenge tests, the capsaicin-induced cough response was most pronounced in female non-atopic asthma patients, suggesting that sensory dysfunction is a potentially important trait in type 2-low asthma 89.…”

Section: Clinical Implication Of Cough Hypersensitivity In Various Comentioning

confidence: 92%

“… 87 In another study of 262 adult patients with severe asthma, the LCQ score only showed moderate correlations with asthma control status, but not with sputum eosinophils (%). 88 Also, in a study using capsaicin cough challenge tests, the capsaicin-induced cough response was most pronounced in female non-atopic asthma patients, suggesting that sensory dysfunction is a potentially important trait in type 2-low asthma. 89 These findings suggest that cough is a major component contributing to asthma pathophysiology independently of conventional factors like lung function or inflammation.…”

Section: Clinical Implication Of Cough Hypersensitivity In Various Comentioning

confidence: 99%

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Cough Hypersensitivity Syndrome: A Few More Steps Forward

Song

Morice

2017

Allergy Asthma Immunol Res

111

110

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Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome. Recent success in randomized clinical trials using a P2X3 receptor antagonist is the first major advance in the therapeutics of cough in the past 30 years; it at last provides a strategy for treating intractable cough as well as an invaluable tool for dissecting the mechanism underpinning cough hypersensitivity. Additionally, several cough measurement tools have been validated for use and will help assess the clinical relevance of cough in various underlying conditions. Along with this paradigm shift, our understanding of cough mechanisms has improved during the past decades, allowing us to continue to take more steps forward in the future.

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Section: Clinical Implication Of Cough Hypersensitivity In Various Comentioning

confidence: 92%

Section: Clinical Implication Of Cough Hypersensitivity In Various Comentioning

confidence: 99%

Cough Hypersensitivity Syndrome: A Few More Steps Forward

Song

Morice

2017

Allergy Asthma Immunol Res

111

110

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“…Assessing the impact of chronic cough in the clinic typically relies on the use of standard instruments for the assessment of other respiratory conditions such as asthma [2,73]. However, these only consider cough as a symptom, and the possibility that the cough represents a distinct condition (CHS) is frequently overlooked, particularly in primary care [23].…”

Section: Diagnosismentioning

confidence: 99%

Chronic cough: new insights and future prospects

et al. 2021

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Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dysregulation. Chronic cough and RCC result in a serious, often unrecognized, disease burden, which forms the focus of the current review.The estimated global prevalence of chronic cough is 2–18%. Patients with chronic cough and RCC report many physical and psychological effects, which impair their quality of life. Chronic cough also has a significant economic burden for the patient and healthcare systems. RCC diagnosis and treatment are often delayed for many years as potential treatable triggers must be excluded first and a stepwise empirical therapeutic regimen is recommended.Evidence supporting most currently recommended treatments is limited. Many treatments do not address the underlying pathology, are used off-label, have limited efficacy and produce significant side-effects. There is therefore a significant unmet need for alternative therapies for RCC that target the underlying disease mechanisms. Early clinical data suggest that antagonists of the purinergic P2X3 receptor, an important mediator of RCC, are promising, though more evidence is needed.

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“…1 Cough is one of the most common symptoms in asthma and is associated with increased severity and poor prognosis, 2,3 yet tools commonly used to evaluate asthma in clinical studies including the Asthma Control Questionnaire (ACQ) do not fully capture cough-related morbidity. 4 Cough is the archetypal airway neuronal reflex, but how this reflex may be modulated in asthma remains poorly understood. In mild/moderate asthma, Satia et al 5 recently demonstrated heightened capsaicin-evoked cough responses.…”

Section: Investigating the Safety Of Capsaicin Cough Challenge In Sevmentioning

confidence: 99%