The Relationship between the Hypnotic Induction Profile and the Stanford Hypnotic Susceptibility Scale, Form C: Revisited

Frischholz, Edward J.; Tryon, Warren W.; Spiegel, Holger; Fisher, Stanley

doi:10.1080/00029157.1981.10403296

Cited by 12 publications

(1 citation statement)

References 13 publications

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“…66 Catechol- O -methyl transferase (COMT), a gene that affects dopamine function, influences prefrontal executive cognition, 67 and an association between a COMT polymorphism and hypnotizability has been shown. 11, 18, 68 69 The val/met heterozygous form is associated with higher hypnotizability, except in one study in which those with the val/val polymorphism were even higher, 69 and may allow for greater frontal lobe dopamine-mediated flexibility in figure/ground attention, representing enhanced attentional control and therefore greater task engagement.…”

Section: Discussionmentioning

confidence: 99%

Functional Brain Basis of Hypnotizability

Hoeft¹,

Gabrieli²,

Whitfield-Gabrieli³

et al. 2012

Arch Gen Psychiatry

122

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Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known. Objective The main goal of the study was to investigate the brain basis of hypnotizability. Design Cross sectional, in-vivo neuroimaging study. Setting Academic medical center at Stanford University School of Medicine. Patients 12 adults with high and 12 adults with low hypnotizability. Main Outcome Measures (1) functional MRI (fMRI) to measure functional connectivity networks at rest including default-mode, salience and executive-control networks, (2) structural T1 MRI to measure regional grey and white matter volumes, and (3) diffusion tensor imaging (DTI) to measure white matter microstructural integrity. Results High-compared to low-hypnotizable individuals showed greater functional connectivity between left dorsolateral prefrontal cortex (DLPFC), an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex (dACC), anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information, using independent component analysis (ICA). Seed based analysis confirmed elevated functional coupling between the dACC and the DLPFC in high, compared to low, hypnotizables. These functional differences were not due to variation in brain structure in these regions, including regional grey and white matter volumes and white matter microstructure. Conclusions Our results provide novel evidence that altered functional connectivity in DLPFC and dACC may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted.

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