The relationship between the gut microbiota, benign prostatic hyperplasia, and erectile dysfunction

Russo, Giorgio Ivan; Bongiorno, Dafne; Bonomo, Carmelo; Musso, Nicolò; Stefani, Stefania; Sokolakis, Ioannis; Hatzichristodolou, Georgios; Falcone, Marco; Cai, Tommaso; Smarrazzo, Francesco; Verze, Paolo

doi:10.1038/s41443-022-00569-1

Cited by 15 publications

(10 citation statements)

References 59 publications

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“…However, another study reported evidence that the origin of urinary microbiota is the gut [ 37 ]. Furthermore, gut microbiota composition and its metabolites can be related to the urinary microbiome and various genitourinary pathologies [ 38 ]. Therefore, further studies are needed to determine the origin of the urinary microbiota and to explore the interaction between the microbiota of urine and other sites in healthy humans.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, proliferation and hypoxia can stimulate the production of reactive oxygen species (ROS), further supporting a vicious cycle [ 11 ]. Another possible etiology is that the gut microbiota alteration, induced by several factors such as age, diet, lifestyle, and drug intake, can influence prostate inflammation status indirectly by activating the immune system [ 38 ]. Gut microbiota alterations could promote an inflammatory condition in distant sites, including the prostate, through the production of proinflammatory cytokines, such as IL-17, IL-23, TNF-alpha, and IFN-gamma [ 58 ].…”

Section: Methodsmentioning

confidence: 99%

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The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms

Yu¹,

Jung²

2022

Diagnostics

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Historically, urine in the urinary tract was considered “sterile” based primarily on culture-dependent methods of bacterial detection. Rapidly developing sequencing methods and analytical techniques have detected bacterial deoxyribonucleic acid and live bacteria in urine, improving our ability to understand the urinary tract microbiome. Recently, many studies have revealed evidence of a microbial presence in human urine in the absence of clinical infections. In women, fascinating evidence associates urinary tract microbiota with lower urinary tract symptoms (LUTS). However, the association between urinary tract microbiota and men with LUTS, particularly those with benign prostate hyperplasia (BPH), has not been established. In addition, the identification of the proinflammatory cytokines and pathogens responsible for the clinical progression of BPH is still underway. This review article aimed to address microbiome-related evidence for BPH. Further studies are required for a comprehensive understanding of the relationship between the urogenital microbiome and BPH pathogenesis to facilitate the development of preventive and therapeutic approaches for male LUTS.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms

Yu¹,

Jung²

2022

Diagnostics

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“…Additionally, it can lead to infertility and disrupt the emotional harmony between spouses. There are various risk factors that can negatively impact male sexual function, including old age, obesity, smoking, physical inactivity, high blood pressure, cardiovascular disease (CVD), diabetes, hyperlipidaemia, metabolic syndrome, anxiety and depression (Geng et al., 2021 ; Russo et al., 2023 ). The International Index of Erectile Function‐5 (IIEF‐5) is a widely used self‐report screening tool for assessing male erectile function (Rosen et al., 1999 ).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous diseases, including inflammatory bowel disease, arthritis, cancer, neuropsychiatric disorders, cardiovascular disease, obesity, type 2 diabetes and infertility, have been linked to the gut microbiota (Badran et al., 2020 ; Fabozzi et al., 2022 ; Papadopoulos et al., 2022 ; Sonali et al., 2022 ; Zhou et al., 2020 ). Inflammatory response, cardiovascular disease and psychological disorders are significant causes and risk factors for ED among the diseases associated with the gut microbiota (Geng et al., 2021 ; Russo et al., 2023 ). Therefore, we hypothesize that there is a correlation between gut microbiota and the occurrence and development of ED.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota composition may be an indicator of erectile dysfunction

Qiao,

Chen,

Jiang

et al. 2024

Microbial Biotechnology

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Erectile Dysfunction (ED) is considered a physical and mental illness. A variety of potential associations between gut microbiota and health or disease have been found. By comparing the gut microbiota of healthy controls and ED patients, our study investigated the relationship between ED and gut microbiota. The results revealed that the ED group exhibited a significantly higher relative abundance of Bacteroides, Fusobacterium, Lachnoclostridium, Escherichia‐Shigella and Megamonas, while showing a significantly lower relative abundance of Bifidobacterium compared to the control group. The dysbiosis of gut microbiota played a role in the onset and progression of ED by influencing the gut barrier, cardiovascular system and mental health, which provided a novel perspective on understanding the pathophysiology of ED. What is more, we had identified several key gut microbiota. By combining 16S rRNA sequencing with machine learning techniques, we were able to uncover the significant value and impact of gut microbiota in the early detection of ED.

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“…Through secretion of various substances, gut microbiota can regulate the permeability of the gut, the composition and function of the intestine cell membrane, epithelial cell function and neurotransmission, which performs functions like regulating host metabolism, maintaining the structural integrity of the gut mucosal barrier, immunomodulation and anti-in ammation (8,10). Gut microbiota may cause ED due to alterations in endocrine sex hormone level, organismal metabolic status and neurotransmitters (11). A cross-sectional research (12) on the correlation between gut microbiota and ED showed a signi cant association between patients' IIEF-5 scores and gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Association between gut microbiota and erectile dysfunction: a two-sample Mendelian randomization study

Chen

Zhang

Zou

et al. 2023

Preprint

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Objective: Several observational studies have recently been reported to suggest an association between gut microbiotaand erectile dysfunction（ED）. However, the causal relationship between gut microbiota and erectile dysfunction remains unclear. Therefore, the aim of this study was to clearly elaborate the causal relationship between gut microbes and erectile dysfunction. Methods: A two-sample Mendelian randomization study was conducted with summary statistics of the gut microbiota from the largest genome-wide association study Meta-analysis conductedby the MiBiogen Consortium (n=13, 266). ED patients’ information was collected from the European ancestry (6175 cases vs 217,630 controls). The causal relation between gut microbiota and ED was investigated using inverse variance weighting (IVW), MR-Egger, weighted median, weighted model, and MR-PRESSO. Reverse Mendelian randomization（MR） analysis was performed on bacteria found to be causally involved in erectile dysfunction in forward Mendelian random analysis. Cochran's Q statistic was employed to quantify the heterogeneity of instrumental variables. Results: IVW estimate indicates that Lachnospiraceae(OR=1.26, 95%CI=1.06 to 1.5, P=0.008), Oscillibacter(OR=1.2, 95%CI=1.04 to 1.39, P=0.016), Tyzzerella3(OR=1.14, 95%CI=1.02 to 1.27, P=0.024) and Erysipelotrichaceae UCG003(OR=2.05, 95%CI=1.54 to 2.56, P=0.006) were risk factor for ED. Sensitivity analyses were performed to verify the causal relations obtained by MR. The results of Cochran’s IVW Q test showed no significant heterogeneity of these IVs. Based on the results of the inverse MR analysis, no obvious causal effect of ED on intestinal flora was found. There was no significant heterogeneity found for instrumental variables or horizontal pleiotropy. Conclusions: This two-sample MR study found that gut microbes including family Lachnospiraceae、genus Erysipelotrichaceae UCG003、genus Oscillibacter、genus Tyzzerella3 were causally associated with ED. Further studies are needed to clarify the mechanism of gut microbes’s pathogenesis role in ED.

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The relationship between the gut microbiota, benign prostatic hyperplasia, and erectile dysfunction

Cited by 15 publications

References 59 publications

The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms

The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms

Gut microbiota composition may be an indicator of erectile dysfunction

Association between gut microbiota and erectile dysfunction: a two-sample Mendelian randomization study

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