The Relationship Between the Fibrinogen to Albumin Ratio and Early Outcomes in Patients  with Acute Pontine Infarction

Zhai, Mingfeng; Cao, Shugang; Lu, Junfeng; Xu, Hui; Xia, Mingwu; Li, Zongyou

doi:10.1177/10760296211067260

Cited by 8 publications

(6 citation statements)

References 30 publications

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“…In addition, albumin neutralizes fibrinogen binding to endothelial cells, thus antagonizing several prothrombotic effects of fibrinogen [ 108 ]. Additionally, endothelial dysfunction and blood viscosity are increased in patients with hypoalbuminemia [ 109 ]. During inflammatory states, the coagulation cascade favors thrombus formation due to the decreased synthesis and increased catabolism of albumin.…”

Section: Discussionmentioning

confidence: 99%

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Wybranowski

Napiórkowska

Bosek

et al. 2022

IJMS

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Oxidative stress induced by neutrophils and hypoxia in COVID-19 pneumonia leads to albumin modification. This may result in elevated levels of advanced oxidation protein products (AOPPs) and advanced lipoxidation end-products (ALEs) that trigger oxidative bursts of neutrophils and thus participate in cytokine storms, accelerating endothelial lung cell injury, leading to respiratory distress. In this study, sixty-six hospitalized COVID-19 patients with respiratory symptoms were studied. AOPPs-HSA was produced in vitro by treating human serum albumin (HSA) with chloramine T. The interaction of malondialdehyde with HSA was studied using time-resolved fluorescence spectroscopy. The findings revealed a significantly elevated level of AOPPs in COVID-19 pneumonia patients on admission to the hospital and one week later as long as they were in the acute phase of infection when compared with values recorded for the same patients 6- and 12-months post-infection. Significant negative correlations of albumin and positive correlations of AOPPs with, e.g., procalcitonin, D-dimers, lactate dehydrogenase, aspartate transaminase, and radiological scores of computed tomography (HRCT), were observed. The AOPPs/albumin ratio was found to be strongly correlated with D-dimers. We suggest that oxidized albumin could be involved in COVID-19 pathophysiology. Some possible clinical consequences of the modification of albumin are also discussed.

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Section: Discussionmentioning

confidence: 99%

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Wybranowski

Napiórkowska

Bosek

et al. 2022

IJMS

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“…Fibrinogen is an inflammation-related protein that participates in thrombokinesis, platelet aggregation, blood viscosity, thrombus formation, and fibrin formation ( Kim and Lee, 2014 ; Zhai et al, 2022 ). Fibrinogen is secreted in the liver and plays a role in cardiovascular risk through the regulation of coagulation and inflammation pathways ( Hou et al, 2021 ).…”

Section: Hemostasis Biomarkersmentioning

confidence: 99%

Biomarkers for prognostic functional recovery poststroke: A narrative review

Zhang

Sánchez-Vidaña

Chan

et al. 2023

Front. Cell Dev. Biol.

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Background and objective: Prediction of poststroke recovery can be expressed by prognostic biomarkers that are related to the pathophysiology of stroke at the cellular and molecular level as well as to the brain structural and functional reserve after stroke at the systems neuroscience level. This study aimed to review potential biomarkers that can predict poststroke functional recovery.Methods: A narrative review was conducted to qualitatively summarize the current evidence on biomarkers used to predict poststroke functional recovery.Results: Neurophysiological measurements and neuroimaging of the brain and a wide diversity of molecules had been used as prognostic biomarkers to predict stroke recovery. Neurophysiological studies using resting-state electroencephalography (EEG) revealed an interhemispheric asymmetry, driven by an increase in low-frequency oscillation and a decrease in high-frequency oscillation in the ipsilesional hemisphere relative to the contralesional side, which was indicative of individual recovery potential. The magnitude of somatosensory evoked potentials and event-related desynchronization elicited by movement in task-related EEG was positively associated with the quantity of recovery. Besides, transcranial magnetic stimulation (TMS) studies revealed the potential values of using motor-evoked potentials (MEP) and TMS-evoked EEG potentials from the ipsilesional motor cortex as prognostic biomarkers. Brain structures measured using magnetic resonance imaging (MRI) have been implicated in stroke outcome prediction. Specifically, the damage to the corticospinal tract (CST) and anatomical motor connections disrupted by stroke lesion predicted motor recovery. In addition, a wide variety of molecular, genetic, and epigenetic biomarkers, including hemostasis, inflammation, tissue remodeling, apoptosis, oxidative stress, infection, metabolism, brain-derived, neuroendocrine, and cardiac biomarkers, etc., were associated with poor functional outcomes after stroke. However, challenges such as mixed evidence and analytical concerns such as specificity and sensitivity have to be addressed before including molecular biomarkers in routine clinical practice.Conclusion: Potential biomarkers with prognostic values for the prediction of functional recovery after stroke have been identified; however, a multimodal approach of biomarkers for prognostic prediction has rarely been studied in the literature. Future studies may incorporate a combination of multiple biomarkers from big data and develop algorithms using data mining methods to predict the recovery potential of patients after stroke in a more precise way.

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“…For example, it has been reported that a high FAR predicts poor functional outcome in patients with acute pontine infarction. 36 Previous studies also found that a high FAR might be an independent predictor of disability and death after lacunar stroke. 5 This present study showed that FAR level was significantly associated with stroke recurrence, poor functional outcome, and dependence in our LAA stroke cohort after adjusting for all confounding risk factors.…”

Section: Discussionmentioning

confidence: 94%

Fibrinogen‐to‐Albumin Ratio and Clinical Outcomes in Patients With Large Artery Atherosclerosis Stroke

Wang,

Bai,

et al. 2023

JAHA

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Background A high fibrinogen‐to‐albumin ratio (FAR), a novel inflammatory marker, is considered to be a prognostic marker in vascular diseases. However, the association of FAR with large artery atherosclerosis (LAA) stroke is still unknown. This study was conducted to evaluate the association between FAR levels and clinical outcomes in patients with acute LAA stroke. Methods and Results A total of 809 patients within 72 hours of LAA stroke were included and followed up to 1 year. FAR was calculated as fibrinogen (g/L)/albumin (g/L). The associations of FAR with clinical outcomes were assessed by multivariate Cox regression or logistic regression analysis. Clinical outcomes included stroke recurrence, all‐cause death, poor functional outcome (modified Rankin Scale score 3–6), and dependence (modified Rankin Scale score 3–5). Among the 809 patients with acute LAA stroke, the median FAR was 0.075 (interquartile range, 0.064–0.087). At 1 year, 103 (12.7%) patients had stroke recurrence, 105 (13.0%) had poor functional outcome, 76 (9.8%) had dependence, and 29 (3.6%) had died. After adjusting for all confounding risk factors, a high FAR level was associated with stroke recurrence (hazard ratio, 2.57 [95% CI, 1.32–5.02]), poor functional outcome (odds ratio, 3.30 [95% CI, 1.57–6.94]), and dependence (odds ratio, 3.49 [95% CI, 1.49–8.19]). Conclusions A high FAR level was associated with an increased risk of stroke recurrence, poor functional outcome, and dependence in patients with acute LAA stroke.

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The Relationship Between the Fibrinogen to Albumin Ratio and Early Outcomes in Patients with Acute Pontine Infarction

Cited by 8 publications

References 30 publications

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Study of Albumin Oxidation in COVID-19 Pneumonia Patients: Possible Mechanisms and Consequences

Biomarkers for prognostic functional recovery poststroke: A narrative review

Fibrinogen‐to‐Albumin Ratio and Clinical Outcomes in Patients With Large Artery Atherosclerosis Stroke

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