The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use

Lim, Sun Gyo; Park, Rae Woong; Shin, Sung Jae; Yoon, Dukyong; Jinsuk, Kang; Hwang, Jae Chul; Kim, Soon Sun; Kim, Jin Hong; Lee, Kee Myung

doi:10.1016/j.dld.2015.12.001

Cited by 57 publications

(49 citation statements)

References 34 publications

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“…A recent study confi rmed an association between number of previous antibiotic exposures and an increasing risk for antibiotic resistance ( 125 ). Similarly, duration of previous macrolide therapy for greater than 2 weeks is also associated with a greater risk of treatment failure with clarithromycin triple therapy ( 126 ).…”

Section: Clarithromycin Triple Therapymentioning

confidence: 99%

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection

Chey

Leontiadis

Howden

et al. 2017

American Journal of Gastroenterology

1,182

1,379

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Helicobacter pylori ( H. pylori ) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-infl ammatory medication, unexplained iron defi ciency anemia, and idiopathic thrombocytopenic purpura. While choosing a treatment regimen for H. pylori , patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process. For fi rst-line treatment, clarithromycin triple therapy should be confi ned to patients with no previous history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pylori isolates is known to be low. Most patients will be better served by fi rst-line treatment with bismuth quadruple therapy or concomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole. When fi rst-line therapy fails, a salvage regimen should avoid antibiotics that were previously used. If a patient received a fi rst-line treatment containing clarithromycin, bismuth quadruple therapy or levofl oxacin salvage regimens are the preferred treatment options. If a patient received fi rst-line bismuth quadruple therapy, clarithromycin or levofl oxacin-containing salvage regimens are the preferred treatment options. Details regarding the drugs, doses and durations of the recommended and suggested fi rst-line and salvage regimens can be found in the guideline. Asia and Central and South America ( 8,22 ). Th ere is, however, preliminary evidence that it may be falling in some previously high prevalence areas ( 22 ). People immigrating to North America from Asia and other parts of the world have a much higher prevalence of the infection than people born in North America ( 23 ). In one study, the seroprevalence among immigrants from East Asia was 70.1% ( 24 ). Hispanic immigrants to North America have higher rates of the infection than fi rst-or second-generation Hispanics who were born here ( 25 ). QUESTION 2: WHAT ARE THE INDICATIONS TO TEST FOR, AND TO TREAT, H. PYLORI INFECTION? RecommendationsSince all patients with a positive test of active infection with H. pylori should be off ered treatment, the critical issue is which patients should be tested for the infection (strong recommendation, quality of evidence: not applicable), All patients with active peptic ulcer disease (PUD), a past history of PUD (unless previous cure of H. pylori infection has been documented), low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma, or a history of endoscopic resection of early gastric cancer (EGC) should be tested for H. pylori infection. Th ose who test positive should be off ered treatment for the infection (strong recommendation, quality of evidence: high for active or history of PUD, low for MALT lymphoma, low for history of endoscopic resection of EGC).In patients with uninvestigated d...

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Section: Clarithromycin Triple Therapymentioning

confidence: 99%

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection

Chey

Leontiadis

Howden

et al. 2017

American Journal of Gastroenterology

1,182

1,379

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“…Levofloxacin is a fluoroquinolone drug with cross‐resistance to other quinolones. The combination of levofloxacin‐based combinations can overcome the drug resistance to some extent . However, the consensus does not recommend using the levofloxacin‐containing regimen as an initial treatment to increase the eradication rate of initial treatment …”

Section: Discussionmentioning

confidence: 99%

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

et al. 2019

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Background & Aims Developing countries are making efforts to improve health management. Practice deviating from the guideline means inefficient control. The study aims to investigate the management of Helicobacter pylori (H pylori) infection from a developing country perspective. Methods An authoritative survey was conducted in 14th (2014) and 17th (2017) Congress of Gastroenterology China, respectively. The Maastricht V/Florence consensus report was invoked as the evaluation criterion. Results A total of 4182 valid samples were included in this study. Most of the respondents (94%) updated knowledge by lectures. Respondents had a different awareness rate of H pylori‐related diseases, ranging from 45% to 95%. Up to 40% of the respondents did not follow the recommendations for the diagnosis. Choice accuracy of eradication regimens and antibiotic combinations was <70%. About 20% of the respondents did not pay attention to the confirmation after the eradication. The situation had been improved in 2017 when compared with that in 2014 (all P < .05). Multivariate logistic regression analysis revealed that influencing factors including nongastroenterologists, bachelor degree and below, the primary professional title, hospital location, and a small proportion of H pylori infection in daily practice related to the deviation of consensus (all P < .05). Conclusions Although the management of H pylori infection has been improved in a developing country, there is still a gap between the real‐world practices and the consensus. Influencing factors should be taken into account in decision‐making, and the corresponding population should be strengthened with precision training during the promotion of the guideline.

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“…En nuestro estudio se seleccionaron las biopsias obtenidas del fondo y antro gástrico como se recomienda (12), mientras que el cultivo se realizó dentro de las 2 horas para evitar la pérdida de la viabilidad de las cepas. Tanto la resistencia "primaria" asociada con el uso de antibióticos para el tratamiento de infecciones causadas por patógenos distintos a H. pylori, como la resistencia "secundaria" causada por un tratamiento previo con el fin de erradicar H. pylori influyen en su erradicación (13)(14)(15). El CLSI establece puntos de corte clínicos para la claritromicina, pero no lo hace para amoxicilina, tetraciclina, metronidazol y levofloxacina.…”

Section: Discussionunclassified

Susceptibilidad antibiótica de Helicobacter pylori: un estudio de prevalencia en pacientes con dispepsia en Quito-Ecuador

Reyes

Guzmán

Morales

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: Helicobacter pylori se lo asocia a patologías gastro-intestinales, el incremento en la resistencia a los antibióticos utilizados para su erradicación es alarmante a nivel mundial. En este estudio se determinó la susceptibilidad a cinco antibióticos utilizados en la terapia de erradicación de H. pylori aislado de una población adulta con dispepsia recurrente en Quito-Ecuador.Materiales y métodos: Previa aceptación del consentimiento informado, se tomaron biopsias de cuerpo y fondo gástrico de 210 pacientes con dispepsia, mediante cultivo se recuperaron los aislados de H. pylori identificado mediante pruebas bioquímicas. La susceptibilidad al metronidazol, claritromicina, amoxicilina, tetraciclina y levofloxacina se realizó por concentración mínima inhibitoria (CMI). Todos los cultivos se correlacionaron con el estudio histopatológico.Resultados: Se recuperaron 89 aislados de H. pylori. Se obtuvo un kappa de 0.9 entre el cultivo y el estudio histopatológico. El porcentaje de cepas con resistencia antibiótica fue: metronidazol (63 %), claritromicina (66 %), amoxicilina (43%), tetraciclina (36%) y levofloxacina (54%).Conclusión: Estos hallazgos demuestran la alta resistencia a los antibióticos usados para la erradicación de H. pylori, varios factores como consumo indiscriminado de antibióticos, terapia previa, etc. podrían estar involucrados.Palabras clave: Helicobacter pylori; resistencia antibiótica; concentración mínima inhibitoria.

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The relationship between the failure to eradicate Helicobacter pylori and previous antibiotics use

Cited by 57 publications

References 34 publications

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection

ACG Clinical Guideline: Treatment of Helicobacter pylori Infection

Management of Helicobacter pylori infection by clinicians: A nationwide survey in a developing country

Susceptibilidad antibiótica de Helicobacter pylori: un estudio de prevalencia en pacientes con dispepsia en Quito-Ecuador

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