The relationship between the exposure to healthcare settings and colonization with methicillin-resistant Staphylococcus aureusamong medical students

Jayaweera, Jayaweera Arachchige Asela Sampath; Pilapitiya, Senaka; Kumbukgolla, Widuranga

doi:10.18683/germs.2020.1183

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…A similar study has been carried out in Rajarata University of Sri Lanka, located in another province of Sri Lanka, in order to evaluate the relationship between the exposure to healthcare settings and colonization with methicillin-resistant Staphylococcus aureus among medical students. The percentage of MRSA colonization found before clinical exposure and after 2.5 years of exposure was 6.36 and 49.57%, respectively [ 10 ]. However, the MRSA colonization rate after the clinical exposure was relatively higher than to the present study.…”

Section: Discussionmentioning

confidence: 99%

Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students

et al. 2021

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Background Antibiotic Resistance is an imminent global public health threat. Antibiotic resistance emerged in healthcare settings and has now moved on to the community settings. This study was conducted to identify the rates of asymptomatic colonization with selected antibiotic resistant organisms, (Methicillin Resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta Lactamase (ESBL) producing Escherichia coli and Klebsiella spp and carbapenem resistant E.coli and Klebsiella spp) - among a group of university students in Sri Lanka. Identification of genetic determinants of MRSA and ESBL was an additional objective of the study. Methods A self - collected nasal swab and a peri-rectal swab collected after passing stools were obtained. Routine microbiological methods were used for the isolation S.aureus from the nasal swab and E.coli and Klebsiella species from the peri-rectal swab. Antibiotic sensitivity testing was performed as recommended by clinical and laboratory standard institute (CLSI). Three (3) genes that are responsible for ESBL production; blaCTX-M, blaSHV, and blaTEM were tested using previously described primers and PCR procedures. Identification of MecA and PVL genes attributed to MRSA was also done with PCR. Results A total of 322 participants between 21 and 28 years were recruited representing 5 different faculties of study. Seventy one (22.0%) were colonized with S.aureus and 14 among them with MRSA, making the MRSA colonization rate of 4.3%. Forty five (15%) of the participants were colonized with an ESBL producing E.coli or Klebsiella spp. No one was colonized with carbapenem resistant E.coli or Klebsiella species. Of the 45 ESBL producers the commonest genetic determinant identified was blaCTX-M (n = 36), while 16 isolates had blaTEM and 7 had blaSHV. Similarly, of the 14 isolates identified as MRSA, 3 (21.4%) were found to be PVL positive while 11 (78.6%) were MecA positive. Conclusions A high rate of colonization with ESBL producing E.coli and Klebsiella species was noted in our study group.

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Section: Discussionmentioning

confidence: 99%

Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students

et al. 2021

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Prevalence of methicillin-resistant Staphylococcus aureus carriage among healthcare workers in South Asia in non-outbreak settings: A systematic review and meta-analysis

Giri¹,

Ghimire²,

Mishra³

et al. 2023

American Journal of Infection Control

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Comment on: "The relationship between the exposure to healthcare settings and colonization with methicillin-resistant Staphylococcus aureusamong medical students”

Rainbow¹,

Dorji²

2020

Germs

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This article 1 provides crucial insights into the ways in which medical students undergoing clinical placement might pose a risk to patients. The authors have identified a key issue in the clinical teaching setting whereby medical students are unknowing carriers for methicillin-resistant Staphylococcus aureus (MRSA), and therefore contributing to the potential spread of this deadly infection to vulnerable patients. Medical students often spend much time with patients as part of their training, involving extended periods of interaction and physical contact through clinical examinations. These provide ample opportunities for patients to become infected with MRSA and could lead to a prolonged hospital stay, a deterioration in their health or even prove fatal. 2 Understanding how and why these medical students come to acquire MRSA may aid in disease prevention and ensure the safety of hospitalized patients.It was found that the risk of being a MRSA carrier increased with the duration of clinical training. Fifth year medical students showed a much higher incidence of nasal and axillary

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The relationship between the exposure to healthcare settings and colonization with methicillin-resistant Staphylococcus aureusamong medical students

Cited by 4 publications

References 17 publications

Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students

Colonization with selected antibiotic resistant bacteria among a cohort of Sri Lankan university students

Prevalence of methicillin-resistant Staphylococcus aureus carriage among healthcare workers in South Asia in non-outbreak settings: A systematic review and meta-analysis

Comment on: "The relationship between the exposure to healthcare settings and colonization with methicillin-resistant Staphylococcus aureusamong medical students”

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