The Relationship Between the E12 Polymorphism of The Thyroglobulin Gene and Hyperthyroidism Diseases in Affected People in Samarra City

Abstract

The study included (90) samples, including (60) samples infected with hyperthyroidism and (30) samples representing the healthy control group. The samples were collected during the period from November 10, 2021, until February 10, 2022, within the laboratories of the city of Samarra. The study included observing the phenotypic symptoms of hyperthyroidism.The results showed that 85% of all patients with hyperthyroidism suffered from bulging eyes, 92% of all patients suffered from increased appetite and weight loss, and 95% of the sample of patients suffered from high temperature in the extremities and high sensitivity to temperature.The study also included identifying the E12 polymorphism of the TG gene, which is responsible for encoding the production of thyroid hormones. Genetic profiling of the E12 polymorphism was conducted. It was observed that there was a difference in the allelic frequency between the affected group and the control group, in addition to a higher incidence of phenotypic symptoms in people carrying the homozygous mutant genotype. GG and the impact of some of their biochemical characteristics, as the results of the study showed the significant impact of hyperthyroidism on the level of blood lipids (CHO, triglycerides (TRI), high-density lipoproteins (HDL-C), low-density lipoproteins (LDL-C), and very low-density lipoproteins (VLDL)) It was observed that there was a decrease in all lipid variables in people with hyperthyroidism, as the arithmetic mean for them was (142.98-107.42-23.28-98.21-21.48), respectively. As for the control group, the arithmetic mean was (190.