The relationship between the distinct ratios of benserazide and carbidopa to levodopa and motor complications in Parkinson's disease: A retrospective cohort study

Baba, Yasuhiko; Futamura, Akinori; Kinno, Ryuta; Nomoto, Shohei; Takahashi, Seiya; Yasumoto, Taro; Osakabe, Yuyuko; Shoji, Daiki; Nabeshima, Yoko

doi:10.1016/j.jns.2022.120263

Cited by 5 publications

(1 citation statement)

References 28 publications

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“…Levodopa in the periphery is susceptible to the metabolism by Catechol-O-methyl transferase (COMT), which can be inhibited by drugs such as Tolcapone or Entacapone and Dopa decarboxylase (DDC), which are inhibited by drugs such as Carbidopa or Benserazide [ 59 , 60 ].…”

Section: Introductionmentioning

confidence: 99%

Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach

et al. 2023

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Parkinson’s disease is a neurodegenerative disorder characterized by slow movement, tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain’s substantia nigra. The concentration of dopamine is decreased in the brain. Parkinson’s disease may be happened because of various genetic and environmental factors. Parkinson’s disease is related to the irregular expression of the monoamine oxidase (MAO) enzyme, precisely type B, which causes the oxidative deamination of biogenic amines such as dopamine. MAO-B inhibitors, available currently in the market, carry various adverse effects such as dizziness, nausea, vomiting, lightheadedness, fainting, etc. So, there is an urgent need to develop new MAO-B inhibitors with minimum side effects. In this review, we have included recently studied compounds (2018 onwards). Agrawal et al . reported MAO-B inhibitors with IC 50 0.0051 µM and showed good binding affinity. Enriquez et al . reported a compound with IC 50 144 nM and bind with some critical amino acid residue Tyr60, Ile198, and Ile199. This article also describes the structure–activity relationship of the compounds and clinical trial studies of related derivatives. These compounds may be used as lead compounds to develop potent compounds as MAO-B inhibitors. Graphic Abstract

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Section: Introductionmentioning

confidence: 99%

Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach

et al. 2023

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Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications

Ali,

Fatima,

Ahmad

et al. 2024

Discov Life

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The present study deals with the bio-fabrication of AgA-AgNPs utilizing edible mushroom Agaricus arvensis as a reductant for improved stability and catalytic efficiency towards L-dopa production. The parameters optimized for achieving maximum tyrosine hydroxylase (TH) activity were the mushroom biomass (2.5%, w/v), media for extraction (peptone-saline), and temperature (90 ℃). The activity of tyrosine hydroxylase (TH) was enhanced by its immobilization on AgNPs. The change in color from light yellow to dark brown confirmed the formation of AgA-AgNPs. In addition, the UV–Vis spectrum showed a surface plasmon resonance band at 260 nm. Fourier transform infrared (FTIR) indicated presence of functional groups, which play an important role in production of NPs. X-ray diffraction (XRD) confirmed the crystalline nature of mycosynthesized AgNPs and showed peaks corresponding to 38.8° (111), 46.5° (200), 64.1° (220), and 77.5o (311). AgA-AgNPs exhibited −9.16 mv zeta potential. Scanning Electron Microscopy (SEM) images of AgA-AgNPs confirmed particle size between 88.49 ± 3.83 nm. Immobilized TH extracted from A. arvensis showed reusability at optimized temperature (20 ℃) for 3 cycles. A 2.54-fold higher production of L-dopa was examined with AgA-AgNPs. Furthermore, immobilized TH consumed more L-tyrosine i.e. 0.554 ± 0.022 mg/ml as compared to the free enzyme at 90 min of biotransformation. Hence, the immobilization of A. arvensis extracted TH on AgNPs increased its activity as well as its stability and catalytic efficiency. AgA-AgNPs has a potential of dopamine synthesis and can play a significant role in drug delivery or biomedical applications.

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Multicolorimetric Sensor Array Based on Silver Metallization of Gold Nanorods for Discriminating Dopaminergic Agents

Koohsar,

Orouji,

Hormozi-Nezhad

2024

ACS Chem. Neurosci.

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The relationship between the distinct ratios of benserazide and carbidopa to levodopa and motor complications in Parkinson's disease: A retrospective cohort study

Cited by 5 publications

References 28 publications

Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach

Recent updates on structural insights of MAO-B inhibitors: a review on target-based approach

Green synthesis of Agaricus avensis-mediated silver nanoparticles for improved catalytic efficiency of tyrosine hydroxylase towards potential biomedical implications

Multicolorimetric Sensor Array Based on Silver Metallization of Gold Nanorods for Discriminating Dopaminergic Agents

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