The relationship between the consumption of meat, fat, and coffee and the risk of colon cancer: A prospective study in Japan

Oba, Shino; Shimizu, Natsuki; Nagata, Chisato; Shimizu, Hiroyuki; Kametani, Masaaki; Takeyama, Naoharu; Ohnuma, Toshikazu; Matsushita, Shogen

doi:10.1016/j.canlet.2005.12.037

Cited by 116 publications

(151 citation statements)

References 23 publications

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“…34 In a study conducted in Japan, daily coffee consumption was associated with a reduced risk of colon cancer in comparison with no or rare consumption only among women (adjusted relative risk 5 0.43, 95% CI 5 0.22-0.85), but not among men (adjusted relative risk 5 0.81, 95% CI 5 0.46-1.42). 36 For these studies, inverse associations between coffee consumption and the risk of colorectal cancer were observed only in subgroups, and not in all subjects. The subgroups of the subjects showing a significant association were inconsistent among the studies, and thus the results could have been due to chance.…”

Section: Discussionmentioning

confidence: 87%

“…Only 1 prospective study of the association between coffee consumption and the risk of colorectal cancer has been carried out in Asia, and this estimated only the risk of colon cancer. 36 Our present study had several strengths. It was based on subjects from the general population in Japan, and we identified a large number of colorectal cases (457 cases) during a long followup period (425,303 person-years).…”

Section: Discussionmentioning

confidence: 89%

“…Ten prospective studies have been conducted to assess the relationship between coffee consumption and colorectal cancer. [27][28][29][30][31][32][33][34][35][36] Among them, 1 argued an increasing risk, 27 3 suggested an inverse association, 29,34,36 and 6 observed no association. 28,[30][31][32][33]35 Our study was consistent with the latter 6 studies.…”

Section: Discussionmentioning

confidence: 99%

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Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Naganuma

Kuriyama

Akhter

et al. 2007

Intl Journal of Cancer

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An inverse association between coffee consumption and the risk of colorectal cancer has been reported in several case-control studies, but results from prospective cohort studies have been inconclusive. We conducted a prospective cohort study among a Japanese population to clarify the association between coffee consumption and the risk of colorectal cancer incidence. We used data from the Miyagi Cohort Study for this analysis. Usable self-administered questionnaires about coffee consumption were returned from 22,836 men and 24,769 women, aged 40-64 years, with no previous history of cancer. We used the Cox proportional-hazard regression model to estimate hazard ratios and 95% confidence intervals. During 11.6 years of follow-up (425,303 person-years), we identified 457 cases of colorectal cancer. Coffee consumption was not associated with the incidence of colorectal, colon or rectal cancer. The multivariate-adjusted hazard ratio (95% confidence interval) of colorectal cancer incidence for 3 or more cups of coffee per day as compared with no consumption was 0.95 (0.65-1.39) for men and women (p for trend 5 0.55), 0.91 (0.56-1.46) for men (p for trend 5 0.53) and 1.16 (0.60-2.23) for women (p for trend 5 0.996). Coffee consumption was also not associated with incidence of either proximal or distal colon cancer. We conclude that coffee consumption is not associated with the incidence risk of colorectal cancer in the general population in Japan. ' 2006 Wiley-Liss, Inc.Key words: coffee; colorectal cancer; incidence; Japan; prospective study Colorectal cancer is one of the most common cancers worldwide. 1,2 In Japan, colorectal cancer ranks second in terms of agestandardized incidence rate among all cancers, and it is increasing rapidly. 3 Therefore, primary prevention of colorectal cancer worldwide, including Japan, is a considerable public health concern.Coffee is considered to be a protective factor against colorectal cancer through activity of its anticarcinogenic constituents, cafestol and kahweol. 4 It may also decrease the risk of colorectal cancer by reducing the excretion of bile acids and neutral sterols into the colon. 5 Some epidemiological studies have examined the relationship between coffee consumption and the risk of colorectal cancer. 6 Sixteen out of 20 case-control studies supported an inverse association between high coffee consumption and colorectal cancer risk. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] However, the results of those studies may have been affected by selection bias or recall bias due to retrospective assessment of coffee consumption and other lifestyles-related factors after diagnosis of cancer. In contrast, results from prospective cohort studies have been inconclusive. [27][28][29][30][31][32][33][34][35][36] Among 10 such studies, 1 suggested an increasing risk, 27 3 showed an inverse association 29,34,36 and the others observed no association. 28,[30][31][32][33]35 However, as the studies that observed any association had some statistical l...

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Naganuma

Kuriyama

Akhter

et al. 2007

Intl Journal of Cancer

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“…The "meat-inducing effect" on CRC may be induced by mutagenic heterocyclic amines and polycyclic aromatic hydrocarbons that are formed during meat cooking at high temperatures. It can also result from nitrites and nitrite derivatives present in the processed meat products that are converted to carcinogenic N-nitroso compounds in the colon [16]. High egg intake and high intake of total cholesterol are other dietetic risk factors of CRC [17].…”

Section: Diet As a Determinant Of Colorectal Cancer Microenvironmentmentioning

confidence: 99%

Recent Advances in Colorectal Cancer Research: The Microenvironment Impact

Houle

Huot

2011

Cancer Microenvironment

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“…Overexpression of enzymes like cyclooxygenase-2 (Cox-2) and chromosomal abnormalities have all been linked to cause adenoma formation (Gustin and Brenner, 2002). Diet is often the best preventive option because it is a major cause attributed to the link of colorectal cancer (WCRFI., 2011;Biasi et al, 2013;Giovannucci et al, 1995;Oba et al, 2006;Gustin and Brenner, 2002;Russo, 2007).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Potential of Coconut Flour in Caco-2 Colon Cancer Cells

Smith¹,

Patterson²,

Walker³

et al. 2015

International J. of Cancer Research

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Coconut Flour (CF) (Cocos nucifera L.) is a sweet by-product of coconut milk that has multifarious utility. The objective of this study was to investigate the chemopreventive potential of coconut flour extracts (defatted and whole) through determination of phytochemical content, antioxidative potential and cytotoxic effects on Caco-2 cells. Phytochemical (total phenolic, total flavonoid) content, Trolox Equivalent Antioxidant Capacity (TEAC), free radical-scavenging ability of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Potential (FRAP) were determined according to standard protocols. Lactate dehydrogenase (LDH) release (cytotoxicity assay) was used to measure in vitro cell damage of Caco-2 colon cancer cells. Activity of antioxidant enzymes was determined with selected concentrations of extracts (25, 50 and 100 μg mLG 1 ). Apoptotic activity was assessed through the activity of caspase-3 and DNA fragmentation Enzyme-Linked Immunosorbant Assay (ELISA). Anti-inflammatory activity was assessed through measuring cycloxygenase-2 (Cox-2). Total phenolic and flavonoid content was 55.46±1.70 mg GAE/100 g and 17.84±2.33 mg CE/100 g. The TEAC was 0.65±0.05 μmol TE/100 g. The DPPH was IC 50 -74 mg mLG

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The relationship between the consumption of meat, fat, and coffee and the risk of colon cancer: A prospective study in Japan

Cited by 116 publications

References 23 publications

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Recent Advances in Colorectal Cancer Research: The Microenvironment Impact

Antioxidant Potential of Coconut Flour in Caco-2 Colon Cancer Cells

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