The Relationship Between the Atherogenic Index of Plasma and Arterial Stiffness in Essential Hypertensive Patients from China: A Cross-Sectional Study

Abstract

Background: The atherogenic index of plasma (AIP) always remains in a potential association with the arterial stiffness, however, in large hypertensive patient populations, this relation is not fully discovered and needs to be studied in depth. The present analysis thus sought to further explore the association that exists between AIP and arterial stiffness in patients diagnosed with arterial hypertension in China.Methods: This cross-sectional study analyzed 4744 Chinese individuals with essential hypertension. AIP was defined as the base 10 logarithm of the ratio of plasma of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-c) levels indicates as in molar concentrations. Measurement of arterial stiffness was carried out via brachial-ankle pulse wave velocity (baPWV).Results: Data were adjusted for potential confounding variables, after which a multivariate linear regression analysis revealed AIP to be positively correlated with baPWV (β = 1.34, 95% CI: 0.96 to 1.72, P < 0.001). When AIP was instead treated as a categorical variable divided into quartiles, this same relationship was observed (P for trend < 0.001). We additionally found AIP and baPWV had a stronger positive association in individuals with a body mass index (BMI) < 24 kg/m2 (P for interaction < 0.05).Conclusion: AIP and arterial stiffness were positively correlated in essential hypertension patients in China, especially in those with a BMI < 24 kg/m2.

Predictive Value of Resting Fractional Flow Reserve and Atherogenic Index of Plasma for Evaluation of Physiologically Significant Coronary Artery Lesions

“…Zhou et al, Wang et al, and Shanker et al reported that AIP was an independent and powerful predictor of the presence of CAD. 8,[20][21][22] Furthermore, evidence suggests AIP may serve as an independent predictor for arterial stiffness, coronary artery calcification progression, rapid coronary plaque progression, instent restenosis, and total coronary occlusion. [22][23][24][25][26] These studies are generally related to the relationship of the AIP index with coronary artery disease's anatomical features and severity.…”

“…8,[20][21][22] Furthermore, evidence suggests AIP may serve as an independent predictor for arterial stiffness, coronary artery calcification progression, rapid coronary plaque progression, instent restenosis, and total coronary occlusion. [22][23][24][25][26] These studies are generally related to the relationship of the AIP index with coronary artery disease's anatomical features and severity. However, there was no further study on the relationship between AIP and the functional severity of coronary artery stenosis.…”

Atherogenic Index of Plasma and the Risk of In-Stent Restenosis in Patients with Acute Coronary Syndrome beyond the Traditional Risk Factors

“…As was independently and strongly associated with the risk of CAD in special populations such as very young adults and postmenopausal women, who usually had the unique risk factor profile 25,26) . Furthermore, mounting evidence suggests AIP may serve as an independent predictor for arterial stiffness, coronary artery calcification progression, and the rapid progression of coronary plaque, all of which were powerful predictors of adverse cardiac events 15,27,28) . Most importantly, Qin et al and Ma et al demonstrated that increased AIP upon admission correlated positively with the worse long-term prognosis in patients after PCI.…”

Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension?

“…In our study, subjects were divided into three categories according to BMI levels (< 25 kg/m^2, control group; 25-30 kg/m^2, overweight; and ≥ 30 kg/m^2, general obesity) [25][26][27]30]. Central obesity was defined as WHR ≥ 0.9 for males and ≥ 0.85 for females [39].…”