The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood

Stevens, Kris; Crespo-Biel, Olga; Bosch, Edith E. M. van den; Dias, Aylvin A.; Knetsch, Menno L. W.; Aldenhoff, Yvette B. J.; Veen, Frederik H. van der; Maessen, Jos G.; Stobberingh, Ellen E.; Koole, Léo H.

doi:10.1016/j.biomaterials.2009.03.054

Cited by 162 publications

(95 citation statements)

References 23 publications

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“…45 Our zymography studies showed that QD-activated platelets released MMP-2, in agreement with previous studies involving NPs. 20 The platelet activation observed in this study is in agreement with a number of previous studies performed using various NPs such as carbon, 21 silver, 18 gold, 19 latex, 46 silica, 47 and particulate matter. 48 Most of these studies were performed using LTA.…”

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confidence: 89%

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CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility

Samuel¹,

Santos-Martínez²,

Medina³

et al. 2015

IJN

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New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests their use for in vivo molecular and cellular imaging. However, the hemocompatibility of QDs and their constituent components has not been fully elucidated. In the present study, comprehensive investigation of QD–platelet interactions is presented. These interactions were shown using transmission electron microscopy. The effects of QDs on platelet function were investigated using light aggregometry, quartz crystal microbalance with dissipation, flow cytometry, and gelatin zymography. Platelet morphology was also analyzed by phase-contrast, immunofluorescence, atomic-force and transmission electron microscopy. We show that the QDs bind to platelet plasma membrane with the resultant upregulation of glycoprotein IIb/IIIa and P-selectin receptors, and release of matrix metalloproteinase-2. These findings unravel for the first time the mechanism of functional response of platelets to ultrasmall QDs in vitro.

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confidence: 89%

“…16 Although platelets serve an important role in the control of physiological hemostasis, they also participate in pathological thrombosis, which is associated with vascular diseases such as myocardial infarction and stroke. 17 The pharmacological responses of platelets to NPs such as Ag, 18 …”

mentioning

confidence: 99%

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility

Samuel¹,

Santos-Martínez²,

Medina³

et al. 2015

IJN

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“…In a recent study by Stevens, a surface coating containing both heparin and silver nanoparticles was studied in vitro [145]. The coatings were demonstrated to have silver dependent antimicrobial activity, but also the coatings with only heparin demonstrated bactericidal activity after incubation in human plasma (vide supra).…”

Section: Blood Compatibility Of Silver Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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“…The bactericidal effects of silver nanoparticles are part of an extensive research field due to its potential translation for biomedical applications such as, wound-healing (Tian et al, 2007;Silver et al, 2006), clothes, coating for medical devices (Roe et al, 2008), antimicrobial gel (Jain et al, 2009), and orthopaedic implants (Nair & Laurencin, 2008). It is well known that the use of central venous catheters is associated with bactericidal line infections, which is a usual problem (Stevens et al, 2009). Contaminated or infected catheters are a major source of nosocomial infections responsible for > 40% of all episodes of nosocomial sepsis in acute-care hospitals (Samuel & Guggenbichler, 2004).…”

Section: Interaction Of Silver Nanoparticles With Bacteriamentioning

confidence: 99%

Silver Nanoparticles Interactions with the Immune System: Implications for Health and Disease

Klippstein¹,

Fernández-Montesinos²,

Castillo³

et al. 2010

Silver Nanoparticles

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The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood

Cited by 162 publications

References 23 publications

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility

CdTe quantum dots induce activation of human platelets: implications for nanoparticle hemocompatibility

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Silver Nanoparticles Interactions with the Immune System: Implications for Health and Disease

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