The Relationship between Tenascin-C Levels and the Complexity of Coronary Lesion after Myocardial Infarction

Abstract

Aim:The increase of tenascin-C levels after myocardial infarction has been demonstrated by previous studies. The relationship between tenascin-C and the grade of stenosis in the infarct-related coronary artery was indeterminate. The aim of this study was to evaluate the relationship between tenascin-C levels and total occlusion after acute myocardial infarction. Method: Fifty-nine patients with subacute anterior myocardial infarction were divided into two groups according to their having a totally or subtotally occluded left anterior desending artery. Plasma tenascin-C, troponin , CK-MB, uric acid, mean platelet volume, and lipid profile levels were also measured. Results: The history of the smoking rate, hypertension and diabetes mellitus were similar in both groups. Hemoglobin, mean platelet volume, serum creatinine, CK-MB, troponin I, serum lipid profile and uric acid levels were similar in the two groups. The CRP and tenascin-C levels were significantly higher in the total occlusion group. Tenascin-C levels were highest in patients with proximal LAD total occlusion and lowest in patients with subtotal LAD occlusion. The tenascin-C levels were correlated with the grade of stenosis (r 0.602, p 0.001). Conclusion: This study demonstrates that higher tenascin-C levels were related with the total occlusion and inflammation after MI. J Atheroscler Thromb, 2011; 18:693-697.

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity

“…An early inflammatory response is generally associated with enhanced TNC levels both in plasma and tissue (13). In this sense, plasma levels of TNC constitute a well-known indicator for inflammatory bowel disease, chronic hepatitis C, or myocardial infarction (30,31). It would be very interesting to evaluate circulating levels of TNC in light of its physiological consequences.…”

The Importance of Cardiac Biomarkers on Remodelling After Myocardial Infarction

“…Increased TNC levels had a relationship with complexity of coronary lesion after MI [17], severity of heart failure and LV remodelling in dilated cardiomyopathy [18]. CRP and neurohormones, which were secreted from cardiomyocytes like atrial natriuretic peptides (ANP) and brain natriuretic peptides (BNP), are also used to show LV remodeling [10,11].…”

Tenascin-C in cardiovascular remodeling: potential impact for diagnosis, prognosis estimation and targeted therapy

“…19,20 Interestingly, higher plasma levels of tenascin-C could be shown to be related with the complexity of coronary lesions after myocardial infarction, especially with total occlusion of the proximal left anterior descending artery and the extent of inflammation after myocardial infarction. 21 A very recent study published by Sakamoto and co-workers could evidence that serum tenascin-C levels are associated with rupture of coronary plaques in patients with acute coronary syndrome. 22 In cardiac tissue of patients suffering from coronary artery disease who underwent cardiac surgery for revascularization, a distinct re-occurrence of fetal variants of tenascin-C could be evidenced on the mRNA as well as on the protein level.…”