The Relationship between Symptoms and IgG and IgE Antibodies in an Office Environment

Malkin, R.A.; Martinez, Kenneth; Marinkovich, Vincent A.; Wilcox, T.G.; Wall, David B.; Biagini, Raymond E.

doi:10.1006/enrs.1997.3800

Cited by 23 publications

(10 citation statements)

References 6 publications

(5 reference statements)

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“…Some office studies have reported a positive association between atopy status and SBS (Björnsson et al, 1998;Malkin et al, 1998;Menzies et al, 1998;Sahlberg et al, 2012), while other studies did not find any association between SBS symptoms and atopy (Bakke et al, 2008;Gomzi et al, 2008). Our data showed that FeNO was associated with SBS symptoms, especially mucosal symptoms.…”

Section: Discussioncontrasting

confidence: 54%

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Lim

Hashim

Said

et al. 2015

Science of The Total Environment

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Section: Discussioncontrasting

confidence: 54%

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Lim

Hashim

Said

et al. 2015

Science of The Total Environment

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“…Other authors have failed to show links between atopy and symptoms. Higher mold IgE levels have been found in individuals exposed to water damaged structures (242,368). Several groups have reported links between Alternaria allergen sensitivity (measured by specific IgE), but the relationship was not as strong as that between routine indoor allergens and asthma (325).…”

Section: Effects Of Stachybotrys In Indoor Air 155mentioning

confidence: 99%

“…Polyvinyl chloride degradation products have been linked to symptoms by using objective physical measures (444). Thus, while evidence suggests a larger amount of allergic markers in individuals exposed to water-damaged structures, the etiology of these changes is far from certain (242). Furthermore, potential fungal antigens are many, and not well identified.…”

Section: Effects Of Stachybotrys In Indoor Air 155mentioning

confidence: 99%

Indoor Mold, Toxigenic Fungi, andStachybotrys chartarum: Infectious Disease Perspective

2003

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Damp buildings often have a moldy smell or obvious mold growth; some molds are human pathogens. This has caused concern regarding health effects of moldy indoor environments and has resulted in many studies of moisture- and mold-damaged buildings. Recently, there have been reports of severe illness as a result of indoor mold exposure, particularly due to Stachybotrys chartarum. While many authors describe a direct relationship between fungal contamination and illness, close examination of the literature reveals a confusing picture. Here, we review the evidence regarding indoor mold exposure and mycotoxicosis, with an emphasis on S. chartarum. We also examine possible end-organ effects, including pulmonary, immunologic, neurologic, and oncologic disorders. We discuss the Cleveland infant idiopathic pulmonary hemorrhage reports in detail, since they provided important impetus for concerns about Stachybotrys. Some valid concerns exist regarding the relationship between indoor mold exposure and human disease. Review of the literature reveals certain fungus-disease associations in humans, including ergotism (Claviceps species), alimentary toxic aleukia (Fusarium), and liver disease (Aspergillys). While many papers suggest a similar relationship between Stachybotrys and human disease, the studies nearly uniformly suffer from significant methodological flaws, making their findings inconclusive. As a result, we have not found well-substantiated supportive evidence of serious illness due to Stachybotrys exposure in the contemporary environment. To address issues of indoor mold-related illness, there is an urgent need for studies using objective markers of illness, relevant animal models, proper epidemiologic techniques, and examination of confounding factors

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“…Long-term exposure to indoor air is thought to induce multiple chemical sensitivity (MCS) or sick building syndrome (SBS), the symptoms of which include headache, insomnia, anxiety, dizziness, depression, mental fatigue, muscle pain, cognitive deficits, and memory and concentration difficulties (Echeverria et al, 1991;Kishi et al, 1993;Malkin et al, 1998). Volatile organic compounds (VOCs) are widely distributed environmental toxicants.…”

Section: Introductionmentioning

confidence: 99%

Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs

Fan¹,

Li²,

Liu³

et al. 2014

Inhalation Toxicology

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To investigate effects of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose volatile organic compounds (VOCs) and the possible mechanism for these effects, 60 male Kunming mice were exposed in 5 similar static chambers, 0 (control) and 4 different doses of VOCs mixture (G1-4) for consecutively 90 d at 2 h/d. The concentrations of VOCs mixture were as follows: formaldehyde, benzene, toluene, and xylene 0.05 + 0.05 + 0.10 + 0.10 mg/m(3), 0.10 + 0.11 + 0.20 + 0.20 mg/m(3), 0.50 + 0.55 + 1.00 + 1.00 mg/m(3), 1.00 +1.10 + 2.00 + 2.00 mg/m(3), respectively, which corresponded to 1/2, 1, 5, and 10 times of indoor air quality standard in China. Morris water maze (MWM) and Grip strength (GS) test were performed in the last 7 weeks. One day following VOCs exposure, oxidative stress markers, neurotransmitters, and cholinergic system enzymes in brain were examined. In addition, the expressions of N-methyl-d-aspartate (NMDA) receptor in hippocampus were determined. VOCs exposure induced behavioral impairment of mice in MWM and GS test. The levels of reactive oxygen species (ROS), malondialdehyde (MDA) and glutamic acid (Glu) were significantly increased, while the acetylcholinesterase (AChE), choline acetyltransferase (ChAT) and acetylcholine (ACh) levels, and the expression of NMDA receptor were significantly decreased in VOCs exposed groups. Results showed that sub-chronic exposure to low-dose VOCs induced damage on physique and motor function, as well as impairment on learning and memory capacity of mice. Oxidative damage, abnormal metabolism of neurotransmitters and cholinergic system enzymes, and the alternation of NMDA receptor expression may be the possible mechanism for VOCs-induced neurotoxicity.

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The Relationship between Symptoms and IgG and IgE Antibodies in an Office Environment

Cited by 23 publications

References 6 publications

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Sick building syndrome (SBS) among office workers in a Malaysian university — Associations with atopy, fractional exhaled nitric oxide (FeNO) and the office environment

Indoor Mold, Toxigenic Fungi, andStachybotrys chartarum: Infectious Disease Perspective

Potential mechanisms of neurobehavioral disturbances in mice caused by sub-chronic exposure to low-dose VOCs

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