The relationship between snp-polymorphisms of the leptin gene and the development of fatty liver disease in dairy cows

Abstract

This article shows the results of studies in the course of which in a comparative aspect the LEP polymorphism was studied in subpopulations of Holstein dairy cattle in cows with fatty hepatosis and in healthy animals. This is the first time such studies are being conducted. In this case, a hepothesis about the relationship of genetic markers, in particular the leptin gene, with the risk of developing and progression of fatty liver disease in a model of dairy cows when determining the frequency of occurrence of genotypes with LEP polymorphisms in groups of animals with hepatosis and healthy animals was studied. The aim of the research was to establish the possible influence of the genotype at the leptin locus (polymorphisms Y7F, A80V, R25C) on the frequency of occurrence of fatty hepatosis in dairy cows. In the course of studies on the A80V, R25C, Y7F loci of the leptin gene, 180 cows were genotyped, where 80 animals were diagnosed with fatty hepatosis and 100 animals were healthy. In the group of healthy Holstein cows, compared with the group of animals with pathology, the RC genotypes (R25C polymorphism) were significantly more frequent, the frequency of the CC genotype (R25C polymorphism), on the contrary, was much higher in the group of animals with fatty hepatosis. Similar trends were noted for another polymorphism (A80V).