The relationship between sleep disorders, quality, and duration and sexual dysfunction: a systematic review and meta-analysis

Dilixiati, Diliyaer; Kadier, Kaisaierjiang; Laihaiti, Duolikun; Lu, Jian-De; Rezhake, Remila; Azhati, Baihetiya; Rexiati, Mulati

doi:10.1093/jsxmed/qdad054

Cited by 3 publications

(1 citation statement)

References 80 publications

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“… 42 Additionally, heightened levels of reactive oxygen species promote arterial stiffness, contributing to the progression of atherosclerosis and vascular endothelial dysfunction, ultimately leading to reduced blood flow to the penis. 43 Moreover, it is significant to acknowledge that patients with CKD commonly experience lowered erythropoietin levels and exhibit heightened levels of prolactin, which ultimately leads to an increased incidence of anemia and decreased levels of hemoglobin. Previous studies have demonstrated that these factors can influence erectile function by impacting hormone secretion.…”

Section: Discussionmentioning

confidence: 99%

Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study

Dilixiati,

Kadier,

et al. 2024

Sexual Medicine

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Background Previous observational studies have found a potential link between prostate disease, particularly prostate cancer (PCa), and kidney disease, specifically chronic renal disease (CKD), in relation to erectile dysfunction (ED), yet the causal relationship between these factors remains uncertain. Aim The study sought to explore the potential causal association between prostate diseases, renal diseases, renal function, and risk of ED. Methods In this study, 5 analytical approaches were employed to explore the causal relationships between various prostate diseases (PCa and benign prostatic hyperplasia), renal diseases (CKD, immunoglobulin A nephropathy, membranous nephropathy, nephrotic syndrome, and kidney ureter calculi), as well as 8 renal function parameters, with regard to ED. All data pertaining to exposure and outcome factors were acquired from publicly accessible genome-wide association studies. The methods used encompassed inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode residual sum and outlier techniques. The MR-Egger intercept test was utilized to assess pleiotropy, while Cochran’s Q statistic was employed to measure heterogeneity. Outcomes We employed inverse variance weighting MR as the primary statistical method to assess the causal relationship between exposure factors and ED. Results Genetically predicted PCa demonstrated a causal association with an elevated risk of ED (odds ratio, 1.125; 95% confidence interval, 1.066-1.186; P < .0001). However, no compelling evidence was found to support associations between genetically determined benign prostatic hyperplasia, CKD, immunoglobulin A nephropathy, membranous nephropathy, nephrotic syndrome, kidney ureter calculi, and the renal function parameters investigated, and the risk of ED. Clinical Implications The risk of ED is considerably amplified in patients diagnosed with PCa, thereby highlighting the importance of addressing ED as a significant concern for clinicians treating individuals with PCa. Strengths and Limitations This study’s strength lies in validating the PCa-ED association using genetic analysis, while its limitation is the heterogeneity in study results. Conclusion The results of this study suggest a potential link between PCa and a higher risk of ED.

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Section: Discussionmentioning

confidence: 99%

Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study

Dilixiati,

Kadier,

et al. 2024

Sexual Medicine

Self Cite

View full text Add to dashboard Cite

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Relationship of insomnia to sexual function and sexual satisfaction: Findings from the sleep and sex survey II

Pigeon,

Youngren,

Carr

et al. 2023

Journal of Psychosomatic Research

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Prevalence of sexual dysfunction in health care workers: a systematic review and meta-analysis

Chen,

Zhang,

Zhou

et al. 2024

Sexual Medicine Reviews

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Introduction Health care workers represent a substantial demographic whose welfare and work efficiency are crucial to public health and societal well-being. However, the prevalence of sexual dysfunction within this group is often overlooked, despite its significant occurrence. Objective To evaluate the worldwide prevalence of sexual dysfunction among health care workers. Methods A comprehensive systematic review and meta-analysis of observational studies ranging from 2003 to 2023 were performed to compile prevalence estimates of sexual dysfunction among health care workers. A random effects model was implemented to amalgamate the prevalence analysis. Study heterogeneity was discerned by I2 and χ2 statistics. To assess potential publication bias, an Egger’s test and a funnel plot were employed. Results This meta-analysis incorporated 39 studies from 16 countries, encompassing 44 017 health care workers. The pooled prevalence of sexual dysfunction among health care workers was 46.79% (95% CI, 38.09%-55.68%), with a slightly higher prevalence of 49.57% (95% CI, 38.18%-61.01%) among clinical health care workers. The most prevalent forms of sexual dysfunction identified were loss of libido (51.26%), erectile dysfunction (36.99%), sexual dissatisfaction (36.90%), pain during intercourse (28.23%), orgasmic disorders (25.13%), low sexual arousal (23.54%), and lubrication disorders (22.62%). Among various health care professions, nurses exhibited the highest prevalence of sexual dysfunction (56.29%), followed by doctors (37.63%) and other health care workers (24.96%). Additionally, female health care workers experienced a higher prevalence of sexual dysfunction (47.61%) as compared with their male counterparts (32.01%). Conclusion This study indicates that nearly half of health care professionals report experiencing sexual dysfunction, with loss of libido being the most common manifestation. Addressing this issue requires a multistakeholder approach.

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The relationship between sleep disorders, quality, and duration and sexual dysfunction: a systematic review and meta-analysis

Cited by 3 publications

References 80 publications

Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study

Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study

Relationship of insomnia to sexual function and sexual satisfaction: Findings from the sleep and sex survey II

Prevalence of sexual dysfunction in health care workers: a systematic review and meta-analysis

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