The Relationship Between Skin and Cortical Bone Thickness in Old Age with Special Reference to Osteoporosis and Diabetes Mellitus: A Roentgenographic Study

Meema, H. E.; Reid, D. B. W.

doi:10.1093/geronj/24.1.28

Cited by 12 publications

(8 citation statements)

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“…Previous studies (Meema ef cil., 1964;Sheppard & Meema, 1967;Black, 1969;Shuster et al, 1975) have shown significantly lower ST in people over 65 years. No significant correlation has been found between obesity and ST whereas a decline in ST has been noted in malnutrition and debilitating diseases (Sheppard & Meema, 1967;Meema & Reid, 1969).…”

Section: Discussionmentioning

confidence: 99%

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Skin Thickness in Patients With Acromegaly and Cushing's Syndrome and Response to Treatment

Ferguson

Donald

Weston

et al. 1983

Clinical Endocrinology

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Radiological assessment of skin thickness (ST) was assessed in 22 patients with acromegaly and 17 patients with Cushing's syndrome. The age ranges of the patients studied and the 55 individuals in the control group were comparable. The skin thickness in males was significantly greater than in females (P less than 0.01). Mean skin thickness in patients with acromegaly and Cushing's syndrome was significantly greater and less respectively than the mean skin thickness of the normal controls (P less than 0.02). Following successful treatment of acromegaly (growth hormone less than 5 micrograms/l) there was a significant reduction in skin thickness (P less than 0.02 males: P less than 0.01 females). The skin thickness declined at approximately 0.3 mm/year for the first two years and more slowly thereafter. A highly significant correlation was observed between the logarithm of the pre and post treatment plasma GH concentrations and ST values. With one exception, all patients with growth hormone (GH) levels greater than 5 micrograms/l had ST values above the normal range. At an average of 4.5 years after successful treatment of Cushing's syndrome the average increase in ST was 0.23 mm (P less than 0.01). It is concluded that the measurement of skin thickness is a useful screening test for both acromegaly and Cushing's syndrome and provides an objective assessment of the clinical response to treatment.

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Section: Discussionmentioning

confidence: 99%

“…With the exception of two patients, one taking phenytoin, all ST values in patients with GH < 5 ~i g 1 were within the normal range. However, phenytoin (Kattan, 1975), local skin disorders and diabetes mellitus (Meema & Reid, 1969;Sheppard & Meema, 1967), may also be associated with increased skin or heel pad thickness.…”

Section: Discussionmentioning

confidence: 99%

Skin Thickness in Patients With Acromegaly and Cushing's Syndrome and Response to Treatment

Ferguson

Donald

Weston

et al. 1983

Clinical Endocrinology

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“…1 ). 14 – 27 The search of Medline, EMBASE and the Cochrane Library provided 1577 citations (976, 563 and 38 respectively). After exclusion of 601 duplicates, we discarded 965 articles: 944 from the title because they were clearly not on the subject and 21 from the abstract (four were clearly not on the subject, five considered other bone disease, six were not in English or in French, and six were reviews).…”

Section: Resultsmentioning

confidence: 99%

“…The skin parameters tested in the included studies were: an estimation of skin thickness in 10 studies (1715 patients), an estimation of skin elasticity in two studies (138 patients) and an estimation of the collagen content in two studies (121 patients). Several devices were used to assess the skin thickness: radiographs, 27 , 32 calipers, 23 , 24 echographs 16 , 17 , 19 – 21 , 42 and a pachymeter. 15 The anatomical site of the measurement of the skin parameter was: the hand only in five studies or 524 patients; the forearm only in five studies or 987 patients; the abdomen only in one study or 76 patients; and several sites in three studies or 194 patients (NR in one study).…”

Section: Resultsmentioning

confidence: 99%

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Correlation between skin and bone parameters in women with postmenopausal osteoporosis

et al. 2018

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Skin and bone share similarities in terms of biochemical composition.Some authors have hypothesized that their properties could evolve concomitantly with age, allowing the estimation of the parameters of one from those of the other.We performed a systematic review of studies reporting the correlation between skin and bone parameters in women with postmenopausal osteoporosis.Fourteen studies – including 1974 patients – were included in the review.Three of these studies included two groups of participants – osteoporotic and non-osteoporotic – in order to compare skin parameters between them: two studies found a significant difference between the two groups and one did not.Eleven of these studies included one population of interest and compared its skin and bone parameters in a continuous manner: eight studies compared dermal thickness to bone mineral density (seven found a significant correlation [R = 0.19–0.486] and one did not); two studies compared skin elasticity to bone mineral density (both found a significant correlation [R = 0.44–0.57); and one study compared skin collagen to bone mineral density and found a significant correlation (R = 0.587).It can be assumed that the estimation of skin alterations from ageing could help in estimating concomitant bone alterations.Cite this article: EFORT Open Rev 2018;3:449-460. DOI: 10.1302/2058-5241.3.160088

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Contractures in diabetes mellitus: The syndrome of limited joint mobility

Kapoor¹,

Sibbitt

1989

Seminars in Arthritis and Rheumatism

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The Relationship Between Skin and Cortical Bone Thickness in Old Age with Special Reference to Osteoporosis and Diabetes Mellitus: A Roentgenographic Study

Cited by 12 publications

References 0 publications

Skin Thickness in Patients With Acromegaly and Cushing's Syndrome and Response to Treatment

Skin Thickness in Patients With Acromegaly and Cushing's Syndrome and Response to Treatment

Correlation between skin and bone parameters in women with postmenopausal osteoporosis

Contractures in diabetes mellitus: The syndrome of limited joint mobility

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