The Relationship Between Severity of Kawasaki Disease and History of Ischemic Heart Disease in the Parents

Shirvani, Fariba; Saket, Sasan; Karimi, Abdollah; Mojtahedzadeh, Saeed; Shiari, Reza; Seifi, Kimia; Shamsy, Somaye

doi:10.5812/pedinfect.27946

Cited by 1 publication

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are studies on what types of CVD risk increase after children with KD grow up. 12 However, to our knowledge, there are no studies on whether a family history of CVD is associated with the development of KD in children. In a current study, fathers of children with severe KD had a higher incidence of only ischemic heart disease, which may be associated with KD in childhood.…”

Section: Discussionmentioning

confidence: 98%

“…In a current study, fathers of children with severe KD had a higher incidence of only ischemic heart disease, which may be associated with KD in childhood. 12 …”

Section: Discussionmentioning

confidence: 99%

“…Some study results revealed higher incidence of ischemic heart disease in fathers of the subjects with severe KD. 12 In this study we identify the risk factors for KD in children with a family history of CVD from a propensity‐score matched analysis in a national cohort.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association of Familial History of Diabetes, Hypertension, Dyslipidemia, Stroke, or Myocardial Infarction With Risk of Kawasaki Disease

Kwak

Kim

et al. 2022

JAHA

View full text Add to dashboard Cite

Background There are few studies on the association with Kawasaki disease in children and the family’s history of cardiovascular disease (CVD). The aim of this study was to identify the association of increased risks for Kawasaki disease in children with a family history of CVD. Methods and Results Clinical data of children born in 2008 and 2009 (n=917 707) were obtained from the National Health Insurance Service and the National Health Screening Program for Infants and Children for this study. The cohort consisted of 495 215 participants (53.8%) who completed the family history questionnaire for children 54 to 60 months old. Family history of CVD included 5 medical conditions: hypertension, dyslipidemia, myocardial infarction, stroke, and diabetes. Kawasaki disease was defined using the disease code, intravenous immunoglobulin prescription, and use of antipyretics for more than 25 days. Severe Kawasaki disease was defined as diagnosis of accompanied cardiac/coronary artery complications or intravenous immunoglobulin use ≥2 times. The incidence rate of Kawasaki disease was 124/100 000 person‐years (95% CI, 117.5–131.5) for children <2 years old, 95/100 000 person‐years (95% CI, 90.5–100.4) in children 2 to 5 years old, and 14/100 000 person‐years (95% CI, 12.6–15.6) in children >5 years old. After propensity‐score matching, 829 participants with a family history of CVD were diagnosed as having Kawasaki disease (0.68% [95% CI, 0.63–0.72]), and 690 patients with Kawasaki disease (0.56% [95% CI, 0.52–0.61]) had no family history of CVD. The family history of CVD was associated with increased risk for Kawasaki disease (risk ratio, 1.20 [95% CI, 1.08–1.32]) but not for severe Kawasaki disease (risk ratio, 1.23 [95% CI, 0.92–1.65]). Conclusions In this nationwide propensity‐score matched study, those with a family history of CVD had a significantly greater risk of Kawasaki disease compared with those who had no family history of CVD.

show abstract

Section: Discussionmentioning

confidence: 98%

“…In a current study, fathers of children with severe KD had a higher incidence of only ischemic heart disease, which may be associated with KD in childhood. 12 …”

Section: Discussionmentioning

confidence: 99%