The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

Aida, Yasuko; Shibata, Yoko; Osaka, Daisuke; Abe, Shuichi; Inoue, Sumito; Fukuzaki, Koji; Tokairin, Yoshikane; Igarashi, Akira; Yamauchi, Keiko; Nemoto, Takako; Nunomiya, Keiko; Kishi, Hiroyuki; Sato, Masamichi; Watanabe, Tetsu; Konta, Tsuneo; Kawata, Sumio; Kato, Takeshi; Kubota, Isao

doi:10.7150/ijms.8.470

Cited by 60 publications

(73 citation statements)

References 40 publications

(46 reference statements)

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“…The only significant difference between these groups was age (see the Results section). In addition, workers in public institutions and many companies did not participate in this research programme for reasons described previously [25]. Differences in type of employment, socioeconomic status or lifestyle, including vitamin B intake, between participants and nonparticipants may have influenced the results.…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved by the institutional ethics committee and all participants gave written informed consent [2]. Cross-sectional analyses of spirometry data for subjects who were enrolled from 2004 to 2005 (n53165) have been reported previously [2,[25][26][27]. Enrolment of subjects continued through 2006, and the additional data for these subjects became available recently.…”

Section: Study Populationmentioning

confidence: 99%

“…Mean BP was calculated as diastolic BP + 0.33 6 (systolic BP -diastolic BP) [25]. Blood samples were taken from the antecubital vein of subjects who had been fasting.…”

Section: Measurementsmentioning

confidence: 99%

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Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

et al. 2012

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Hyperhomocysteinaemia is associated with chronic obstructive pulmonary disease. However, the relationship between plasma homocysteine levels and spirometric measures has not been investigated in a general population. We aimed to determine whether homocysteine levels are predictive for a rapid decline in lung function among healthy current smokers.Blood sampling and spirometry were performed on subjects participating in a community-based annual health check in Takahata, Japan, from 2004 to 2006 (n53257). Spirometry was re-evaluated in 147 male current smokers in 2009.On initial assessment, forced vital capacity (FVC) % predicted and forced expiratory volume in 1 s (FEV1) % predicted correlated inversely with homocysteine levels and were predictive for homocysteine levels, independent of various clinical factors. Homocysteine levels were higher in subjects with restrictive, obstructive or mixed ventilatory disorders. In addition, homocysteine levels were higher in subjects with mixed ventilatory disorders, compared with restrictive or obstructive disorders. On follow-up, subjects showing a decline in FEV1 had higher homocysteine levels than those who did not. Logistic regression analysis indicated that homocysteine levels were predictive for a decline in FEV1.FVC % pred and FEV1 % pred were significantly associated with homocysteine levels, and hyperhomocysteinaemia predicted the annual rate of decline in FEV1 among male smokers. @ERSpublications Plasma homocysteine levels predict rate of lung function decline in male smokers

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Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

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Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

et al. 2012

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“…Impairment of pulmonary function reduces oxygen intake, resulting in tissue hypoxia which is more prominent during AECOPD. Serum uric acid levels have been associated with the presence of airflow obstruction in a general population in Japan [9], whereas a small cross-sectional study showed significant associations between serum uric acid to creatinine ratio and spirometry values and dyspnoea in COPD patients [10]. Despite the above evidence, to date, no study has evaluated the role of uric acid levels on admission for acute exacerbations of COPD on the outcome of exacerbation and the longterm survival and exacerbation frequency of COPD patients.…”

Section: Introductionmentioning

confidence: 98%

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Bartziokas

Papaioannou

Loukides

et al. 2013

European Respiratory Journal

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Serum uric acid is increased in respiratory disease, especially in the presence of hypoxia and systemic inflammation. We evaluated serum uric acid as a biomarker for prediction of mortality and future acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Serum uric acid was measured in 314 eligible consecutive patients on admission for AECOPD. Patients were evaluated monthly for 1 year.Uric acid levels were higher in patients with more severe airflow limitation and in those experiencing frequent exacerbations. High uric acid levels (o6.9 mg?dL -1 ) were an independent predictor of 30-day mortality in multivariate Cox regression analysis (HR 1.317, 95% CI 1.011-1.736; p50.044), but not of 1-year mortality. Patients with high serum uric acid required more prolonged hospitalisation, and more often needed noninvasive ventilation and admission to the intensive care unit within 30 days. In addition, high uric acid levels were associated with increased risk and hospitalisation for AECOPD in 1 year in multivariate Poisson regression analysis (incidence rate ratio 1.184 (95% CI 1.125-1.246) and 1.190 (95% CI 1.105-1.282), respectively; both p,0.001).Serum uric acid is associated with increased 30-day mortality and risk for AECOPD and hospitalisations in 1-year follow-up. This low-cost biomarker may be useful in the identification of high-risk chronic obstructive pulmonary disease patients that could benefit from intensive management. @ERSpublications Serum uric acid was linked with airflow limitation in COPD and predicted mortality and future exacerbations

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“…7 There is data regarding the significance of serum uric acid level among patients with COPD. [8][9][10][11][12] Serum uric acid has been proposed as a marker of impaired oxidative metabolism and an independent prognostic marker in several cardio-vascular disorders such as congestive heart failure [13][14] pulmonary hypertension 15 and myocardial infarction and its related complications. [16][17] There are other biomarkers also which helps in assessing severity of COPD [18][19] but they are not easily available and are costlier also.…”

Section: Introductionmentioning

confidence: 99%

Correlation of serum uric acid levels in patients of chronic obstructive pulmonary disease

2020

PJMS

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To evaluate serum uric acid level and correlate with the classification of chronic obstructive pulmonary disease (COPD) severity based on post-bronchodilator FEV1 as per Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. It is an institution based cross-sectional study in which 100 patients were included. Patients were screened for COPD. Clinical profile and oxygen saturation were included. Patients were classified according to GOLD guidelines. We found that serum uric acid level was at higher side in patients of severe and very severe stages of COPD compared to mild and moderate stages. Inverse relationship found between FEV1 and serum uric acid level. We concluded that uric acid is a widely available, easy to interpret, low cost biomarker, suggests the possible role in the identification of COPD patients of increased risk for adverse outcomes that may need early intensive management.

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The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

Cited by 60 publications

References 40 publications

Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

Hyperhomocysteinaemia predicts the decline in pulmonary function in healthy male smokers

Serum uric acid as a predictor of mortality and future exacerbations of COPD

Correlation of serum uric acid levels in patients of chronic obstructive pulmonary disease

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