The Relationship between Serum Titers of Autoantibodies to C1q and Age in the General Population and in Patients with Systemic Lupus Erythematosus

Siegert, C. E. H.; Daha, Mohamed R.; Swaak, A. J. G.; Voort, E. A. M. Van Der; Breedveld, Ferdinand C.

doi:10.1006/clin.1993.1066

Cited by 49 publications

(25 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the presence of anti-C1q antibodies has also been identified in the serum of patients with other connective tissue diseases without renal involvement or even in the normal population (21). Thus, the possibility that these antibodies may represent only an epiphenomenon cannot be entirely excluded.…”

Section: Discussionmentioning

confidence: 99%

Anti‐C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus

Moura

Lima

Barbosa³

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background: Anti‐C1q antibodies have been described in systemic lupus erythematosus (SLE) as well as in other connective tissue diseases. They have been considered as a marker for disease activity and presence of nephritis.Objective: The aim of this study was to determine the prevalence of anti‐C1q antibodies in Brazilian lupus patients as well as analyze their association with different clinical and serologic parameters.Methods: Sera from 81 SLE patients, based on the American College of Rheumatology (ACR) criteria, were collected from a lupus referral outpatient clinic in Salvador, Brazil. Antibodies to C1q were detected by an enzyme‐linked immunoassay (ELISA) kit and antibodies to other cellular antigens identified by indirect immunofluorescence on HEp‐2 cell substrate (ANA), or Crithidia luciliae (dsDNA), and to nucleosome by ELISA. A cutoff of 20 U wasestablished for anti‐C1q and antinucleosome assays.Results: Anti‐C1q antibodies were detected in 39.5% (32/81) of SLE sera. The presence of anti‐C1q antibodies was associated with proteinuria (P=0.028) but not with other laboratory or clinical features, such as antinucleosome or anti‐dsDNA antibodies, hematuria, urinary casts or renal failure, leukopenia, pericarditis, pleuritis, malar rash, seizures, and psychosis. There was a positive correlation between the titers of anti‐C1q antibodies and the systemic lupuis erythematosus disease activity index (SLEDAI) score (r=0.370; P=0.001).Conclusion: This study in Brazilian SLE patients confirms previous findings of the association of anti‐C1q antibodies with nephritis and disease activity. J. Clin. Lab. Anal. 23:19–23, 2009. © 2009 Wiley‐Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti‐C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus

Moura

Lima

Barbosa³

et al. 2009

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…Given the known properties of Fc␥RIIa, these findings suggest that IgG2-containing immune complexes are important in lupus nephritis. IgG autoantibodies to the collagen-like region (CLR) of C1q are found in SLE patients (30)(31)(32), especially young patients with severe disease (33), and specifically correlate with the presence of proliferative glomerulonephritis (30). The titer of anti-C1q CLR has been related to the quantity of subendothelial glomerular deposition (34).…”

Section: Discussionmentioning

confidence: 99%

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Salmon¹,

Millard²,

Schachter³

et al. 1996

J. Clin. Invest.

457

289

View full text Add to dashboard Cite

Allelic variants of Fc ␥ R confer distinct phagocytic capacities providing a mechanism for heritable susceptibility to immune complex disease. Human Fc ␥ RIIa has two codominantly expressed alleles, R131 and H131, which differ substantially in their ability to ligate human IgG2. The Fc ␥ RIIa-H131 is the only human Fc ␥ R which recognizes IgG2 efficiently and optimal IgG2 handling occurs only in the homozygous state. Therefore, since immune complex clearance is essential in SLE, we hypothesized that Fc ␥ RIIA genes are important disease susceptibility factors for SLE, particularly lupus nephritis. In a two-stage cross-sectional study, we compared the distribution of Fc ␥ RIIA alleles in African Americans with SLE to that in African American non-SLE controls. A pilot study of 43 SLE patients and 39 controls demonstrated a skewed distribution of Fc ␥ RIIA alleles, with only 9% of SLE patients homozygous for Fc ␥ RIIa-H131 compared with 36% of controls (odds ratio, 0.18; 95% CI, 0.05-0.69, P ϭ 0.009). This was confirmed with a multicenter study of 214 SLE patients and 100 non-SLE controls. The altered distribution of Fc ␥ RIIA alleles was most striking in lupus nephritis. Trend analysis of the genotype distribution showed a highly significant decrease in Fc ␥ RIIA-H131 as the likelihood for lupus nephritis increased ( P ϭ 0.0004) consistent with a protective effect of the Fc ␥ RIIA-H131 gene. The skewing in the distribution of Fc ␥ RIIA alleles identifies this gene as a risk factor with pathophysiologic importance for the SLE diathesis in African Americans. ( J.

show abstract

“…32 Anti-C1q antibodies have been described in many conditions. They are detected in all patients with hypocomplementemic urticarial vasculitis, 33,34 although they do not seem to have a pathogenic role in this entity.…”

Section: Clinical Significancementioning

confidence: 99%

Anti-C1q in systemic lupus erythematosus

Stojan

Petri

2016

Lupus

View full text Add to dashboard Cite

C1q is the first component of the classical complement pathway. Both clinically validated inhouse ELISA assays as well as commercial ELISA kits are used for detection of anti-C1q antibodies. Anti-C1q autoantibodies can be detected in a wide range of autoimmune diseases and are highly sensitive for hypocomplementemic uticarial vasculitis. In SLE, anti-C1q are strongly associated with proliferative lupus nephritis, and their absence carries a negative predictive value for development of lupus nephritis of close to 100%. Anti-C1q in combination with anti-dsDNA and low complement has the strongest serological association with renal involvement. The anti-C1q titers correlate with global disease activity scores in patients with renal involvement, and higher titers seem to precede renal flares. After the successful treatment of a renal flare, anti-C1q has the tendency to decrease or even become undetectable. The main obstacle to the inclusion of anti-C1q in the classification criteria and clinical management of SLE is the lack of standardized laboratory assays. Lupus (2016) 25, 873-877.

show abstract

The Relationship between Serum Titers of Autoantibodies to C1q and Age in the General Population and in Patients with Systemic Lupus Erythematosus

Cited by 49 publications

References 0 publications

Anti‐C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus

Anti‐C1q antibodies: association with nephritis and disease activity in systemic lupus erythematosus

Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.

Anti-C1q in systemic lupus erythematosus

Contact Info

Product

Resources

About