1993
DOI: 10.1006/clin.1993.1066
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The Relationship between Serum Titers of Autoantibodies to C1q and Age in the General Population and in Patients with Systemic Lupus Erythematosus

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Cited by 49 publications
(25 citation statements)
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“…On the other hand, the presence of anti-C1q antibodies has also been identified in the serum of patients with other connective tissue diseases without renal involvement or even in the normal population (21). Thus, the possibility that these antibodies may represent only an epiphenomenon cannot be entirely excluded.…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, the presence of anti-C1q antibodies has also been identified in the serum of patients with other connective tissue diseases without renal involvement or even in the normal population (21). Thus, the possibility that these antibodies may represent only an epiphenomenon cannot be entirely excluded.…”
Section: Discussionmentioning
confidence: 99%
“…Given the known properties of Fc␥RIIa, these findings suggest that IgG2-containing immune complexes are important in lupus nephritis. IgG autoantibodies to the collagen-like region (CLR) of C1q are found in SLE patients (30)(31)(32), especially young patients with severe disease (33), and specifically correlate with the presence of proliferative glomerulonephritis (30). The titer of anti-C1q CLR has been related to the quantity of subendothelial glomerular deposition (34).…”
Section: Discussionmentioning
confidence: 99%
“…32 Anti-C1q antibodies have been described in many conditions. They are detected in all patients with hypocomplementemic urticarial vasculitis, 33,34 although they do not seem to have a pathogenic role in this entity.…”
Section: Clinical Significancementioning
confidence: 99%