The relationship between serum thyrotropin and components of metabolic syndrome

Lai, Yaxin; Wang, Jiani; Jiang, Feifei; Wang, Beibei; Chen, Yanyan; Li, Mengchun; Li, He; Li, Chenyan; Xue, Haibo; Li, Ningna; Yu, Jin; Shi, Liye; Bai, Xue; Hou, Xin; Zhu, Lin; Lu, Li; Wang, Sen; Xing, Qinghe; Teng, Xiaochun; Wang, Teng; Shan, Zhongyan

doi:10.1507/endocrj.k10e-272

Cited by 126 publications

(121 citation statements)

References 31 publications

(34 reference statements)

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“…28 Unlike our study Lai et al observed significantly higher TG and lower HDL-C in patients with SCH than euthyroid individuals in their study on 1534 Chinese adults. 29 In our study LDL-C and TC were positively correlated with TSH level (p value<0.05) (Figure 2 and 3) in patients of SCH. Santi et al also observed a positive correlation of LDL-C and TC with TSH such patients.…”

Section: Discussionsupporting

confidence: 58%

A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

Kumar

Rajpoot

2016

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 58%

A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

Kumar

Rajpoot

2016

Int J Res Med Sci

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“…In younger populations, associations with other components of the metabolic syndrome such as TC, triglycerides, blood pressure, and waist circumference were observed (5,6,7,8,9). In subgroup analyses of persons 70 years and older, Asvold et al found a significant association between serum TSH and blood pressure (diastolic blood pressure in men and women, and systolic blood pressure only in women).…”

Section: Discussionmentioning

confidence: 99%

Thyroid function and the metabolic syndrome in older persons: a population-based study

Heima

Eekhoff

Oosterwerff

et al. 2013

European Journal of Endocrinology

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Background: Studies suggest an association between a high TSH and (individual components of) the metabolic syndrome. Only a few studies have been performed in the general older population. Objective: This study investigates the association between serum TSH and the metabolic syndrome in a representative sample of older persons in The Netherlands. Design and patients: Data of the Longitudinal Aging Study Amsterdam were used, which is an ongoing cohort study in a representative sample of Dutch older persons. A total of 1187 subjects (590 men and 597 women) between the ages of 65 and 88 years participated in the study. Measurements: Metabolic syndrome (US National Cholesterol Education Program definition) and its individual components were assessed, as well as serum TSH levels. Results: Among the participants, the prevalence of the metabolic syndrome was 34.2%. The mean serum TSH was 1.9 mU/l. Subjects in the upper quartile with a serum TSH level above 2.28 mU/l (odds ratio (OR)Z1.68; 95% confidence interval (CI) 1.19-2.37) had a significantly increased prevalence of metabolic syndrome compared with subjects in the lowest quartile with a serum TSH below 1.04 mU/l. After adjustment for confounders, age, sex, alcohol use, total physical activity, and smoking, the OR was 1.62 (95% CI 1.15-2.32). Conclusions: Subjects with a serum TSH in the upper quartile have a higher prevalence of metabolic syndrome as compared with subjects with a serum TSH in the lowest quartile.

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“…30 Our results were in association with Lai et al, where the higher levels of TGL and Lower HDL levels were observed. 31 Similarly, Iqbal et al, also claimed similar results in SCH patients after performing a follow-up study in males, whereas increased cholesterol, LDL cholesterol and apo B levels in females. 32 On the contrary, total cholesterol levels were not found to be elevated in Rottedam study.…”

Section: Discussionmentioning

confidence: 74%

Prevalence of subclinical hypothyroidism in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia

2017

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Background: The thyroid dysfunction particularly, subclinical hypothyroidism (SCH) is quite a common clinical condition in paediatric population but there is limited data available regarding its prevalence in children and adolescents in our population. The present study was aimed to know the prevalence of thyroid dysfunction particularly SCH in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia.Methods: A retrospective study of 600 subjects (Children=272, Adolescents=328) between 6-19 years of age were included and the following parameters were examined: age, sex, total triiodothyronine (tT3), total tetraiodothyronine (tT4), thyroid stimulating hormone (TSH), total cholesterol, triglycerides (TGL), LDL and HDL cholesterol. The subjects were divided into group I and group II on the basis of age (in years), subjects between 6- ≤12 years age were grouped as group I and 12-≤19 years were as group II.Results: Out of 272 children and 328 adolescents studied, the prevalence of thyroid dysfunction was found to be 9.9% and 10.4 % respectively. The prevalence of subclinical hypothyroidism in children was 7.7% where as 4.9% in adolescents. In both the groups, females were predominantly affected with thyroid dysfunction as compared to males. Significantly elevated serum levels of total cholesterol, TSH and TGL were observed in SCH subjects when compared to euthyroid subjects (p<0.05). Statistically significant lower levels of HDL cholesterol were found in SCH as compared to euthyroids (p<0.05). However, no difference was noticed in the levels of total T3, total T4 and LDL cholesterol between SCH and euthyroids.Conclusions: The prevalence of thyroid dysfunction was found to be 10.2% in study population. SCH was observed in 7.7 % and 4.9% respectively in children and adolescent groups. Subclinical hypothyroidism (SCH) was the most predominant thyroid dysfunction found in our studied population with a prevalence of 6.2% (both children and adolescents). Correction of thyroid dysfunction particularly SCH in early childhood is highly essential to prevent the impairment of psychomotor and cognitive development.

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The relationship between serum thyrotropin and components of metabolic syndrome

Cited by 126 publications

References 31 publications

A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

A study of lipid profile in patients of subclinical hypothyroidism in rural area of Western Uttar Pradesh, India

Thyroid function and the metabolic syndrome in older persons: a population-based study

Prevalence of subclinical hypothyroidism in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia

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