The Relationship between Serum Iron and Thyroid Function in the Patients
with Type 2 Diabetes

Wang, Congcong; Wen, Shuhao; Yuan, Xinlu; Zhou, Mingyue; Li, Yanyan; Gong, Min; Jin, Jianlan; Zhou, Long

doi:10.2174/1871530322666220928144548

Cited by 1 publication

(3 citation statements)

References 24 publications

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“…Smoking affects thyroid function 42,62,63 . Iron deficiency impairs thyroid metabolism 30,31 . Thyroid function correlates with renal function 33,34 .…”

Section: Discussionmentioning

confidence: 99%

“… 42 , 62 , 63 Iron deficiency impairs thyroid metabolism. 30 , 31 Thyroid function correlates with renal function. 33 , 34 We also performed subgroup analyses of these factors, such as alcohol consumption, smoking, serum iron, and creatinine, but no significant interaction was found for these factors.…”

Section: Discussionmentioning

confidence: 99%

“…Considering these factors, the importance of iodine for thyroxine synthesis, the fact that iron deficiency impairs thyroid metabolism, and the correlation between thyroid function and renal function, we also included urinary iodine concentration (UIC), serum iron (Fe), and creatinine (Cre) in our study. 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 Non‐Hispanic White, Mexican American, Non‐Hispanic Black, and Other were the four categories used to classify ethnicity. For subgroup analyses, all continuous variables were converted to categorical variables.…”

Section: Methodsmentioning

confidence: 99%

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The relationship between dietary inflammatory index values and thyroid function in the US adult population: An analysis of the NHANES 2007–2012 cohort

Wang,

Lu,

Zheng

et al. 2023

Immunity Inflam & Disease

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ObjectiveResearchers have developed the Dietary Inflammatory Index (DII) as a tool to quantify the inflammatory potential of a given diet. Higher DII scores indicated a more proinflammatory diet. While inflammation is known to have a strong impact on thyroid function, the precise nature of the association between DII scores and thyroid function has yet to be clarified. This study was conducted with the goal of exploring this relationship in a representative population of adults from the United States.MethodsFor this study, we used data from the National Health and Nutrition Examination Survey (NHANES). Standardized questionnaires were used to collect demographic and dietary data from the participants, and laboratory tests were used to collect data on the participants' thyroid parameters and other relevant data. Linear regression models and smoothed curve fitting were used to assess the relationship between DII scores and thyroid function, with weighted data analyses and subgroup analyses being conducted as appropriate.ResultsIn total, 7712 subjects were recruited from the NHANES 2007–2012 cohort. Their weighted mean age was 44.87 (0.47) years, mean DII score was 1.41 (0.05). Mean FT3 was 3.20 (0.01) pg/mL and mean TT4 was 7.81 (0.03) µg/dL. In adjusted analyses, higher DII values were related to increases in FT3 (β = .007; p = .027) and TT4 (β = .050; p = .005) levels. Subgroup analyses showed a negative correlation between FT3 levels and DII scores in a population with high urinary iodine concentrations.ConclusionThese data indicate that the consumption of a more proinflammatory diet, as evidenced by elevated DII scores, is correlated with significant increases in FT3 and TT4 levels. However, for people with high urinary iodine concentrations, a more proinflammatory diet was associated with lower FT3 levels. Additional research will be vital to clarify the mechanistic basis for these findings.

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“…Smoking affects thyroid function 42,62,63 . Iron deficiency impairs thyroid metabolism 30,31 . Thyroid function correlates with renal function 33,34 .…”

Section: Discussionmentioning

confidence: 99%