The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome

Çiftçi, Tansu Ulukavak; Köktürk, Oğuz; Bukan, Neslihan; Bi̇lgi̇han, Ayşe

doi:10.1016/j.cyto.2004.07.003

Cited by 263 publications

(232 citation statements)

References 17 publications

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“…In correlation analysis, TNF-α, Il-6 and CRP were significantly and directly associated with the AHI and ODI. Our findings are similar to many case-controlled researches demonstrated increased level of TNF-α in patient with OSA in comparison to controls, along with significant reduction in TNF-α value with CPAP therapy [24][25][26]. Further studies proved that TNF-α level was increased in OSA [27][28][29].…”

Section: Discussionsupporting

confidence: 77%

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Jiffri

2017

GHOA

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Background: Obstructive sleep apnea (OSA) is recognized as a major public health issue, as it has a significant influence on the incidence and prognosis of cardiovascular diseases.Objective: This study was designed to detect the association between OSA and biomarkers of inflammation and adhesion molecules that may be useful in medical screening for OSA.Methods: Sixty-five volunteer subjects were interviewed. However, only 64 of them met eligibility criteria. Their age ranged from 28-53 years and their body mass index (BMI) ranged from 30 to 40 kg/m 2 . All participants who were enrolled into two groups according to value of Apnea-hypopnea index (AHI) into two groups: Group (A) consisted of 27 obese subjects with AHI ≥5 events/hour and group (B) consisted of 38 obese subjects with AHI <5 events/hour.

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Section: Discussionsupporting

confidence: 77%

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Jiffri

2017

GHOA

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“…Third, oxidative stress owing to repetitive hypoxia elevated cytokine levels (e.g. tumor necrosis factor-; TNF-and interleukin-6; IL-6) 25) , which led to increased insulin resistance 26) . Fourth, sleep deprivation and the stress there from inhibited slow wave sleep and activated the hypothalamic-pituitaryadrenal axis 27) .…”

Section: Discussionmentioning

confidence: 99%

Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Muraki

Tanigawa

Yamagishi

et al. 2010

JAT

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Aim:We investigated whether nocturnal intermittent hypoxia, a surrogate marker for obstructive sleep apnea, is associated with metabolic syndrome and its components among Japanese. Methods: We examined 1,710 male and 2,896 female community-dwelling Japanese aged 40 to 69, who participated in annual cardiovascular examinations and investigations of sleep. Nocturnal intermittent hypoxia was estimated based on a 3% oxygen desaturation index measured with pulse-oximetry during sleep. No, mild and moderate-to-severe nocturnal intermittent hypoxia were defined by 5, 5 to 15 and ≥ 15 events/hour, respectively. Metabolic syndrome was defined by modified criteria of the Adult Treatment Panel guidelines. Results: Compared with no nocturnal intermittent hypoxia, the multivariable odds ratio of metabolic syndrome was 1.9 (95% confidence interval: 1.6 − 2.4) for mild and 3.2 (2.2 − 4.7) for moderate-tosevere nocturnal intermittent hypoxia among men; 2.6 (2.1 − 3.4) and 5.8 (3.4 − 9.8) among women, respectively. When stratified by overweight status (body mass index ≥ 25 kg/m 2 ), the multivariable odds ratio of two or more metabolic risk factors (other than overweight) associated with moderateto-severe nocturnal intermittent hypoxia was 1.9 (1.2 − 3.1) among non-overweight subjects and 1.4 (0.9 − 2.1) among overweight subjects (p for interaction 0.002). Conclusions: Nocturnal intermittent hypoxia was associated with the accumulation of metabolic risk factors, especially among non-overweight individuals.

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“…Furthermore, C-reactive protein, an acute phase reactant produced by the liver and adipocytes and influenced by IL-6 levels, has been found to be increased in sleep apnea, but is considered to be related mostly to obesity [111]. Finally, TNF-a, a cytokine involved in systemic inflammation, is also elevated in sleep apnea, independently of BMI, and may play a role in the pathogenesis of asthma [112].…”

Section: Obstructive Sleep Apneamentioning

confidence: 99%

Asthma-related comorbidities

Boulet¹,

Boulay²

2011

Expert Review of Respiratory Medicine

219

147

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The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome

Cited by 263 publications

References 17 publications

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Study of Insulin Resistance, Inflammatory Cytokines and Adhesive Molecules in Obese Subjects with Obstructive Sleep Apnea

Nocturnal Intermittent Hypoxia and Metabolic Syndrome; the Effect of being Overweight: the CIRCS Study

Asthma-related comorbidities

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