The Relationship Between Serum Copper and Overweight/Obesity: a Meta-analysis

Gu, Kunfang; Li, Xuekui; Xiang, Wenzhi; Jiang, Xiubo

doi:10.1007/s12011-019-01803-6

Cited by 54 publications

(34 citation statements)

References 42 publications

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“…We also observed a higher Cu concentration among overweight women compared to those within the recommended weight category. This observation is consistent with other studies showing a generally positive association between serum Cu level and obesity (a recent meta-analysis by Gu et al, 2020), or a positive association between Cu level in serum or adipose tissue and BMI [72,73], which, altogether, suggest that Cu status is strongly related to BMI, independently of pregnancy. Interestingly, Yang et al (2019) have found that total Cu levels positively correlate with leptin, insulin, and leptin/BMI suggesting that Cu and/or cuproproteins may be functionally linked to fat accumulation [73].…”

Section: Discussionsupporting

confidence: 93%

Determinants of the Essential Elements and Vitamins Intake and Status during Pregnancy: A Descriptive Study in Polish Mother and Child Cohort

et al. 2021

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The study objective was to identify determinants of essential elements and vitamins intake, and microelements and vitamins concentration in blood among pregnant women from Poland. Based on the data from food frequency questionnaires and information about supplements taken (n = 1252), daily supply of six elements (calcium, magnesium, iron, zinc, copper, selenium) and nine vitamins (folate, vitamins A, E, C, B1, B2, B3, B6, B12) was calculated. Zinc, copper, selenium (n = 340), vitamin A and E (n = 358) concentration was determined in blood collected during pregnancy. Most of the women did not meet the demand for essential elements and vitamins with a diet. About 94% of the respondents declared supplements use. The women with higher education, indicating leisure-time, physical activity and multiparity had a higher chance of meeting the average demand for the majority of the analyzed nutrients. On the other hand, factors such as BMI < 18.5kg/m2, a higher level of stress, and late first medical-care visit were associated with a lower chance of meeting the recommendations. Higher socio-economic status was a determinant of a higher selenium concentration in plasma (β = 3.1; 95%CI: 0.2–5.9), whereas BMI ≥ 25 kg/m2, and multiparity of a higher copper concentration in plasma (β = 0.2; 95%CI: 0.03-0.4; β = 0.2; 95%CI: 0.1–0.4). Higher plasma concentration of vitamin E was noted among women older than 30 years of age comparing to those who were 30 or younger (β = 1.5; 95%CI: 0.6–2.4). Although more studies are required, especially such based on laboratory measures, our results indicate target groups for dietary interventions during pregnancy for children’s optimal health and development.

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Section: Discussionsupporting

confidence: 93%

Determinants of the Essential Elements and Vitamins Intake and Status during Pregnancy: A Descriptive Study in Polish Mother and Child Cohort

et al. 2021

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“…Not one patient had stunted growth, but there were two overweight patients (an 8-and a 13-year-old) and obesity (a 2-and a 25-year-old) according to the waist-to-height index. This fact is interesting because it has been shown in a meta-analysis that a higher level of serum copper could be associated with the risk of obesity in children and adults [54]. Furthermore, in this series, linear regression analysis showed that there was a direct association between serum copper levels and BMI (R 2 = 0.236, p = 0.048).…”

Section: Discussionmentioning

confidence: 51%

Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

et al. 2020

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Cystic fibrosis (CF) patients require a stable and sufficient supply of micronutrients. Since copper is an essential micronutrient for human development, a cross-sectional study was carried out to investigate the serum copper levels, serum copper/zinc (Cu/Zn) ratios, and their relationship with nutritional indicators in a group of CF patients. Anthropometric, biochemical, and dietary measurements, an abdominal ultrasound, and respiratory and pancreatic tests were conducted. Seventeen CF patients were studied (10 females, 59%), 76.5% of whom were ∆F580. Their mean serum copper (113 ± 23 μg/dL) was normal, and there was only one teenager with hypocupremia (6%) and two children with hypercupremia (18%). A significant association between serum copper and zinc levels was discovered. The Cu/Zn ratio was higher than 1.00 for 94% of patients, which is an indicator of an inflammation status. There was no significant correlation between the serum copper concentrations and respiratory and pancreatic function, respiratory colonization, and the results of the abdominal ultrasound. Linear regression analysis showed that serum copper had a positive association with both the Z-score body mass index (BMI) and mean bone conduction speed (BCS). Therefore, since 94% of CF patients had a Cu/Zn ratio > 1.00, this factor must alert us to consider the risk of zinc deficiency and high inflammatory response. The measurement of serum zinc alone does not show one’s zinc status. However, the Cu/Zn ratio may be an indicator of zinc deficiency and the inflammatory status of CF patients.

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“…However, data on the association of obesity and selenium are contradictory and/or insufficient [ 7 ]. In contrast, accumulating evidence demonstrate that obesity may be associated with copper accumulation [ 8 ]. However, multiple contradictions regarding the association between obesity and trace element status exist [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance

et al. 2021

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The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30–70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects.

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The Relationship Between Serum Copper and Overweight/Obesity: a Meta-analysis

Cited by 54 publications

References 42 publications

Determinants of the Essential Elements and Vitamins Intake and Status during Pregnancy: A Descriptive Study in Polish Mother and Child Cohort

Determinants of the Essential Elements and Vitamins Intake and Status during Pregnancy: A Descriptive Study in Polish Mother and Child Cohort

Copper and Copper/Zinc Ratio in a Series of Cystic Fibrosis Patients

Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance

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