The relationship between serum bilirubin concentration and coronary slow flow

Demir, Mehmet; Demir, Canan; Coşar, Selvi

doi:10.1177/1753944713514473

Cited by 8 publications

(9 citation statements)

References 27 publications

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“…Close associations were observed between low serum bilirubin concentrations and increased cardiovascular disease risk factors in the Hong Kong Chinese population [55]. Serum bilirubin levels have been identified as an inverse risk factor for coronary artery disease [56,57] and carotid plaques [58]. Surprisingly, mildly elevated serum bilirubin, has a protective effect comparable to that of high-density lipoprotein cholesterol [59].…”

Section: Molecular Mechanisms Linking Bilirubin To Cardiac Diseasesmentioning

confidence: 89%

The pharmacological features of bilirubin: the question of the century

Zahir

Rabbani

Khan

et al. 2015

Cellular and Molecular Biology Letters

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This review looks at the toxicity and metabolism of bilirubin in terms of its pharmacological potential. Its role has gained importance as more research has revealed the functional significance and interrelationship between the gasotransmitters nitric oxide and carbon monoxide. The biological actions of bilirubin have mostly been characterized in the high micromolar range where toxic effects occur. However, it could also prove to be an important cytoprotector for brain tissue, which is inherently less equipped for antioxidant defense. Plasma bilirubin levels negatively correlate to a number of disease states. Higher levels of bilirubin that are still within the normal range provide a protective effect to the body. The effects on various disorders could be tested using controlled pharmacological upregulation of the molecule with animal models. At nanomolar concentrations, considerable benefits have been obtained when the molecule was delivered pharmacologically under in vitro or in vivo test conditions, particularly in neurodegenerative disorders and after tissue or organ transplantation. The induction of heme oxygenase-1 (HMOX-1) via the activation of nuclear factor erythroid 2-related factor or the use of bile pigments in the harvesting of diseased tissue are novel applications, and like every new therapy, should be used with caution. HMOX-1 is tissue specific, and in exceptional states, such as schizophrenia and specific types of renal disorder, the same therapy may have disastrous effects.

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Section: Molecular Mechanisms Linking Bilirubin To Cardiac Diseasesmentioning

confidence: 89%

The pharmacological features of bilirubin: the question of the century

Zahir

Rabbani

Khan

et al. 2015

Cellular and Molecular Biology Letters

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“…In vitro and in vivo evidence demonstrate that bilirubin is an endogenous antioxidant, which may inhibit the oxidation of lipid and lipoprotein under physiological conditions ( 6 , 21 ). It is estimated that bilirubin accounts for approximately 10% of all antioxidant effects in healthy adults, and the level of bilirubin is negatively associated with serum levels of oxidative biomarkers ( 22 , 23 ). Increased levels of bilirubin may therefore result in higher antioxidant effects, which in turn reduce the risk of developing MetS.…”

Section: Discussionmentioning

confidence: 99%

Serum total bilirubin levels are negatively correlated with metabolic syndrome in aged Chinese women: a community-based study

Zhong

Sun²,

et al. 2017

Braz J Med Biol Res

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We evaluated serum total bilirubin levels as a predictor for metabolic syndrome (MetS) and investigated the relationship between serum total bilirubin levels and MetS prevalence. This cross-sectional study included 1728 participants over 65 years of age from Eastern China. Anthropometric data, lifestyle information, and previous medical history were collected. We then measured serum levels of fasting blood-glucose, total cholesterol, triglycerides, and total bilirubin, as well as alanine aminotransferase activity. The prevalence of MetS and each of its individual component were calculated per quartile of total bilirubin level. Logistic regression was used to assess the correlation between serum total bilirubin levels and MetS. Total bilirubin level in the women who did not have MetS was significantly higher than in those who had MetS (P<0.001). Serum total bilirubin quartiles were linearly and negatively correlated with MetS prevalence and hypertriglyceridemia (HTG) in females (P<0.005). Logistic regression showed that serum total bilirubin was an independent predictor of MetS for females (OR: 0.910, 95%CI: 0.863–0.960; P=0.001). The present study suggests that physiological levels of serum total bilirubin might be an independent risk factor for aged Chinese women, and the prevalence of MetS and HTG are negatively correlated to serum total bilirubin levels.

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“…[11][12][13][14] Various epidemiological studies have demonstrated inverse correlation of serum bilirubin with cardiovascular risk factors such as the systemic blood pressure, blood lipids and glucose levels, and obesity. [11][12][13][14] Hence, the findings of serum bilirubin, white blood cells, and lipid profile are in agreement with above studies. The finding is of clinical importance as regards the risk of CVD and role of WBC that is already proven.…”

Section: Discussionmentioning

confidence: 99%

“…19 Still another postulated mechanism says an indirect linking factor might be influencing the inverse association of serum bilirubin and WBC counts. [11][12][13][14] A previous study 11 proposed the inverse correlation of serum bilirubin and metabolic syndrome is because of the regulatory effects of serum bilirubin upon the insulin resistance that is the core defect of pathophysiology of the metabolic syndrome. Other in-vivo animal studies.…”

Section: Discussionmentioning

confidence: 99%

Serum Bilirubin level and its correlation with white blood cells as risk factor for cardiovascular disease in adult healthy population.

Shaikh¹,

Shaikh²,

Memon³

et al. 2020

TPMJ

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Objectives: Evaluate serum bilirubin in adult healthy subjects and its correlation with white blood cells as risk factor for cardiovascular disease. Study Design: Cross- sectional study. Setting: Department of Pharmacology and Medicine, Suleman Roshan Medical College. Period: January - December 2017. Material & Methods: A sample of 100 male and 100 female adult healthy subjects were recruited for study protocol. Blood glucose, Serum creatinine, Blood lipids, liver enzyme levels, White blood cell counts and Serum bilirubin levels were analyzed. Pearson`s correlation was used for the correlation coefficient and its statistical significance for the association of serum bilirubin and white blood cells. Data variables were analyzed by statistical software SPSS (ver 21.0) at 95% CI (P ≤ 0.05). Results: Mean± SD age of male and female was found 47.02±8.42 and 48.59±7.80 years respectively (P=0.071). Serum bilirubin shows statistically significant negative correlation with blood glucose (r= - 0.257, P=0.0001) and LDLc (r= - 0.155, P=0.027) and WBC (r= - 0.871, P=0.0001). Conclusion: The present study shows the elevated serum total bilirubin levels within reference range correlated negatively with total white blood cells in adult healthy population.

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The relationship between serum bilirubin concentration and coronary slow flow

Abstract: The study revealed a relationship between serum bilirubin and CSF.

Cited by 8 publications

References 27 publications

The pharmacological features of bilirubin: the question of the century

The pharmacological features of bilirubin: the question of the century

Serum total bilirubin levels are negatively correlated with metabolic syndrome in aged Chinese women: a community-based study

Serum Bilirubin level and its correlation with white blood cells as risk factor for cardiovascular disease in adult healthy population.

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