The relationship between semen parameters in processed and unprocessed semen with IUI success rate

Mollaahmadi, Leila; Ghiasi, Ashraf; Hashemzadeah, Mozhgan

doi:10.4274/jtgga.2018.0089

Cited by 1 publication

(2 citation statements)

References 17 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study found the impact of inseminate motility to vary based on other clinical factors of ovarian stimulation type and female age. These conclusions support previous findings that found motility in the inseminate to be most predictive of IUI success [27,[36][37][38][39].…”

Section: Discussionsupporting

confidence: 92%

“…total motile sperm counts in the inseminate found no cut-off value with both high sensitivity and specificity [25]. Other semen parameters including morphology and total progressive motility have shown similarly mixed results [13,[26][27][28][29]. A recent systematic review by Ombelet et al identified a significant lack of standardization or identified threshold values for semen parameters known to impact IUI success [28].…”

Section: Studies Reportingmentioning

confidence: 99%

See 1 more Smart Citation

Intrauterine insemination cycles: prediction of success and thresholds for poor prognosis and futile care

Ainsworth

Barnard

Baumgarten

et al. 2020

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose We aimed to define intrauterine insemination (IUI) cycle characteristics associated with viable birth, identify thresholds below which IUI treatments are consistent with very poor prognosis and futile care, and develop a nomogram for individualized application. Methods This retrospective cohort study evaluated couples using fresh partner ejaculate for IUI from January 2005 to September 2017. Variables included female age, semen characteristics, and ovarian stimulation type. Using cycle-level data, we evaluated the association of these characteristics with the probability of viable birth by fitting generalized regression models for a binary outcome with a logit link function, using generalized estimating equation methodology to account for the correlation between cycles involving the same patient. ResultsThe cohort consisted of 1117 women with 2912 IUI cycles; viable birth was achieved in 275 (9.4%) cycles. Futile care (viable birth rate < 1%) was identified for women age > 43, regardless of stimulation type or inseminate motility (IM). Very poor prognosis (viable birth rate < 5%) was identified for women using oral medications or Clomid plus gonadotropins who were (1) age < 35 with IM < 49%, (2) age 35-37 with IM < 56%, or (3) age ≥ 38, and (4) women age ≥ 38 using gonadotropins only with IM < 60%. A clinical prediction model and nomogram was developed with an optimism-corrected c-statistic of 0.611. Conclusions The present study highlights the impact of multiple clinical factors on IUI success, identifies criteria consistent with very poor prognosis and futile care, and provides a nomogram to individualize counseling regarding the probability of a viable birth.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Studies Reportingmentioning

confidence: 99%

Intrauterine insemination cycles: prediction of success and thresholds for poor prognosis and futile care

Ainsworth

Barnard

Baumgarten

et al. 2020

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

The relationship between semen parameters in processed and unprocessed semen with IUI success rate

Abstract: Sperm motility and normal sperm morphology have effect in IUI success.

Cited by 1 publication

References 17 publications

Intrauterine insemination cycles: prediction of success and thresholds for poor prognosis and futile care

Intrauterine insemination cycles: prediction of success and thresholds for poor prognosis and futile care

Contact Info

Product

Resources

About