The Relationship Between Schizophrenia and Criminality

Ciubară, Alexandru Bogdan; Cartas, N.; Burlea, Lucian Ștefan; Chiriță, Roxana; Ciubara, Bogdan Alexandru; Untu, Ilinca; Iliescu, D. Bulgaru

doi:10.1016/s0924-9338(15)30603-9

Cited by 8 publications

(6 citation statements)

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“…The pathogenic mechanisms presented can be objectified by neuroimaging examinations, which can bring benefits in the diagnostic accuracy and re-evaluation of the therapeutic approach, especially in correlation with the severity of biological markers (Ciubara et al, 2015). It is important to monitor biological markers over time, especially prolactin and sodium, their severe change being an indication for neuroimaging examination.…”

Section: Neuroimaging Evaluationmentioning

confidence: 99%

Drug-Induced Hyperprolactinemia and Hyponatremia - Biological Markers of Unfavorable Evolution in Schizophrenia

Stovicek

Marinescu

Păuna-Cristian

et al. 2022

BRAIN

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Adverse reactions to psychotropic medication can be considered as risk indicators for an unfavorable evolution of patients with schizophrenia, based on particular pathogenic mechanisms that can be used in the personalized therapeutic approach. The combination of antidepressants with antipsychotic drugs in schizophrenia has a risk of synergistic action of excessive blockade of dopamine receptors, which causes hyperprolactinemia. Primary hyponatremia occurs during pregnancy and can be an important marker for signaling neurodevelopmental abnormalities, while secondary hyponatremia has a major clinical dimension and is induced by psychotropic drugs. The pathogenic mechanisms presented can be objectified by neuroimaging examinations that bring benefits in the diagnostic accuracy and re-evaluation of the therapeutic approach, especially in correlation with the severity of biological markers such as prolactin and sodium. The persistence of high prolactin and low sodium levels is an alarm signal that announces a negative evolution of the patient or a major risk of severe cardiac, metabolic, vascular or renal comorbidities. Recognition of pathogenic mechanisms of neurodevelopment, including ventriculomegaly, hyponatremia, focal cortical dysplasia, hippocampal or temporal lobe lesions, in association with a positive history of neonatal or febrile seizures, requires prophylaxis due to high risk of onset of schizophrenia in childhood. Fetal cortical dysplasia is associated with the risk of neonatal seizures. This vulnerability favors the appearance of febrile convulsions or enuresis with changes in brain structure. Enuresis may be an important marker of neurodevelopmental potential for schizophrenia. Neonatal seizures are correlated with hyponatremia and severe hypertension, which appeared in the third trimester of pregnancy, can trigger eclampsia. Neuroimaging monitoring in patients with neurodevelopmental abnormalities, hyperprolactinemia and primary or secondary hyponatremia, acquires a major importance, being able to delimit the boundary between a functional lesion, potentially reversible, with an irreversible lesion.

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Section: Neuroimaging Evaluationmentioning

confidence: 99%

Drug-Induced Hyperprolactinemia and Hyponatremia - Biological Markers of Unfavorable Evolution in Schizophrenia

Stovicek

Marinescu

Păuna-Cristian

et al. 2022

BRAIN

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“…During childhood, the risk factors associated with the development of this psychiatric disorder are mainly represented by mental traumas, such as parental separation, infections, or head injuries (Ciubara et al, 2015;Tandon et al, 2008).…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Evaluation of the Salivary Flow in Patients with Schizophrenia. A Literature Review

Taraboanta

Tărăboanţă-Gamen

Burlea

et al. 2022

BRAIN

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Schizophrenia is a chronic psychiatric disease that affects approximately 1% of the global population. Schizophrenia is characterised by positive, negative and cognitive symptoms. The etiological factors of this psychiatric illness are not fully deciphered, but the most incriminated are genetic factors and environmental risk factors. The treatment of schizophrenia has the role of reduction the duration and intensity of episodes and consists in the administration of typical or atypical antipsychotic drugs, antiparkinsonian, anxiolytic, sedatives or antidepressants. Of these, some of the drugs may have side effects that modify patients' salivary flow rates. Xerostomy is a subjective sign characterized by a dry mouth sensation and is caused by hypofunction of the salivary glands. According to a series of studies, xerostomia can be an adverse effect of typical antipsychotic medication as well as antiparkinsonian medication. Sialorrhea is caused by hyperfunction of the salivary glands and is characterized by an increased secretion of saliva. This side effect is especially noticeable during the night sleep. Alteration of salivary function creates increased discomfort to the schizophrenic patient, which causes him to give up regular medication. The aim of this study is to review the literature on the link between schizophrenia, the treatment of schizophrenia and impaired salivary function.

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“…One of the many explanations for how schizophrenia first manifests is that it starts during fetal development (Ciubara et al, 2015;Collins & Kellner, 1986). Pregnancy bleeding, obstetric complications, instances of gestational diabetes, if the infant was delivered by emergency cesarean section, perinatal asphyxia, and reduced weight at birth were indicators of the late onset of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…While many authors have noted a decline in sexual function, Akhtar and Thomson indicate a period of hypersexuality and promiscuity at the premature and early outset of the disease in their description of schizophrenia and sexuality (Aizenberg et al, 1995;Ciubara et al, 2015). Men with recent-onset schizophrenia were found to be sexually active, with the majority of their behavior being autoerotic, according to research by Lukoff et al from 1986 (American Psychiatric Association, 2013, pp.…”

Section: Introductionmentioning

confidence: 99%

Sexual Dysfunctions in Schizophrenia - A General Overview of Relevant Clinical Symptoms

Moraru¹,

Radulescu²,

Roșu³

et al. 2023

The European Conference of Psychiatry and Mental Health "Galatia"

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Sexuality in schizophrenia has been and still is a taboo subject, difficult to address, both for the patient and the clinician. Poor communication links are a major non-compliance factor, with schizophrenia requiring special attention in terms of therapeutic conduct, which requires a thorough evaluation. By nature of the disease, schizophrenic patients struggle to establish and maintain healthy intimate relationships. They frequently lack the psycho-social abilities required to create and sustain interpersonal connections.

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The Relationship Between Schizophrenia and Criminality

Cited by 8 publications

References 0 publications

Drug-Induced Hyperprolactinemia and Hyponatremia - Biological Markers of Unfavorable Evolution in Schizophrenia

Drug-Induced Hyperprolactinemia and Hyponatremia - Biological Markers of Unfavorable Evolution in Schizophrenia

Evaluation of the Salivary Flow in Patients with Schizophrenia. A Literature Review

Sexual Dysfunctions in Schizophrenia - A General Overview of Relevant Clinical Symptoms

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