The relationship between reverse redistribution of 99mTc-tetrofosmin in sub-acute phase and left ventricular functional recovery in chronic phase in patients with acute myocardial infarction

Abstract

These findings suggested that quantitative evaluation of RRD by gated (99m)Tc-tetrofosmin SPECT in the sub-acute phase can predict recovery of left ventricular function in the chronic phase with higher accuracy in patients with AMI who underwent direct PCI.

Efficacy of myocardial washout of 99mTc-MIBI/Tetrofosmin for the evaluation of inflammation in patients with cardiac sarcoidosis: comparison with 18F-fluorodeoxyglucose positron emission tomography findings

“…The washout phenomenon, which releases 99m Tc-labeled tracer outside of the myocardium, reflects impaired retention of technetium resulting from mitochondrial dysfunction (11,12). It is classically observed in acute myocardial infarction after percutaneous coronary intervention, indicating salvaged myocardial areas and predicting left ventricular functional recovery in the chronic state (20,21). The washout of 99m Tc-labeled tracer has also been observed in non-ischemic cardiac diseases such as left bundle branch block, hypertrophic cardiomyopathy, and dilated cardiomyopathy (22)(23)(24).…”

“…There were a few cases with 99m Tc-labeled tracer washout and diffuse FDG uptake as shown in the representative images (Figure 2). The washout phenomenon could be caused by not only myocardial inflammation but also other mitochondrial injuries as mentioned above (20)(21)(22)(23)(24). It is obviously important to evaluate myocardial inflammation by using multimodality clinical findings with reference to 99m Tc-labeled tracer washout.…”